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Page 1
The discovery of potent nonstructural protein 5A (NS5A) inhibitors with a unique resistance profile-Part 1.
Tran TD, Wakenhut F, Pickford C, Shaw S, Westby M, Smith-Burchnell C, Watson L, Paradowski M, Milbank J, Brimage RA, Halstead R, Glen R, Wilson CP, Adam F, Hay D, Chiva JY, Nichols C, Blakemore DC, Gardner I, Dayal S, Pike A, Webster R, Pryde DC. Tran TD, et al. Among authors: paradowski m. ChemMedChem. 2014 Jul;9(7):1378-86. doi: 10.1002/cmdc.201400045. Epub 2014 Apr 11. ChemMedChem. 2014. PMID: 24729513
The discovery of potent nonstructural protein 5A (NS5A) inhibitors with a unique resistance profile-Part 2.
Wakenhut F, Tran TD, Pickford C, Shaw S, Westby M, Smith-Burchnell C, Watson L, Paradowski M, Milbank J, Stonehouse D, Cheung K, Wybrow R, Daverio F, Crook S, Statham K, Leese D, Stead D, Adam F, Hay D, Roberts LR, Chiva JY, Nichols C, Blakemore DC, Goetz GH, Che Y, Gardner I, Dayal S, Pike A, Webster R, Pryde DC. Wakenhut F, et al. Among authors: paradowski m. ChemMedChem. 2014 Jul;9(7):1387-96. doi: 10.1002/cmdc.201400046. Epub 2014 Apr 11. ChemMedChem. 2014. PMID: 24729518
Synthesis of novel histamine H4 receptor antagonists.
Lane CA, Hay D, Mowbray CE, Paradowski M, Selby MD, Swain NA, Williams DH. Lane CA, et al. Among authors: paradowski m. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1156-9. doi: 10.1016/j.bmcl.2011.11.098. Epub 2011 Dec 1. Bioorg Med Chem Lett. 2012. PMID: 22189138
Challenges of drug discovery in novel target space. The discovery and evaluation of PF-3893787: a novel histamine H4 receptor antagonist.
Mowbray CE, Bell AS, Clarke NP, Collins M, Jones RM, Lane CA, Liu WL, Newman SD, Paradowski M, Schenck EJ, Selby MD, Swain NA, Williams DH. Mowbray CE, et al. Among authors: paradowski m. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6596-602. doi: 10.1016/j.bmcl.2011.07.125. Epub 2011 Aug 9. Bioorg Med Chem Lett. 2011. PMID: 21920751
Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion.
Cockerill GS, Angell RM, Bedernjak A, Chuckowree I, Fraser I, Gascon-Simorte J, Gilman MSA, Good JAD, Harland R, Johnson SM, Ludes-Meyers JH, Littler E, Lumley J, Lunn G, Mathews N, McLellan JS, Paradowski M, Peeples ME, Scott C, Tait D, Taylor G, Thom M, Thomas E, Villalonga Barber C, Ward SE, Watterson D, Williams G, Young P, Powell K. Cockerill GS, et al. Among authors: paradowski m. J Med Chem. 2021 Apr 8;64(7):3658-3676. doi: 10.1021/acs.jmedchem.0c01882. Epub 2021 Mar 17. J Med Chem. 2021. PMID: 33729773
Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2.
Hornyak P, Askwith T, Walker S, Komulainen E, Paradowski M, Pennicott LE, Bartlett EJ, Brissett NC, Raoof A, Watson M, Jordan AM, Ogilvie DJ, Ward SE, Atack JR, Pearl LH, Caldecott KW, Oliver AW. Hornyak P, et al. Among authors: paradowski m. Biochem J. 2016 Jul 1;473(13):1869-79. doi: 10.1042/BCJ20160180. Epub 2016 Apr 20. Biochem J. 2016. PMID: 27099339 Free PMC article.
Regiocontrolled rearrangement of isobenzofurans.
Egan BA, Paradowski M, Thomas LH, Marquez R. Egan BA, et al. Among authors: paradowski m. Org Lett. 2011 Apr 15;13(8):2086-9. doi: 10.1021/ol200498k. Epub 2011 Mar 23. Org Lett. 2011. PMID: 21428447
A challenge finding P2X1 and P2X4 ligands.
Beswick P, Wahab B, Honey MA, Paradowski M, Jiang K, Lochner M, Murrell-Lagnado RD, Thompson AJ. Beswick P, et al. Among authors: paradowski m. Neuropharmacology. 2019 Oct;157:107674. doi: 10.1016/j.neuropharm.2019.107674. Epub 2019 Jun 24. Neuropharmacology. 2019. PMID: 31238045 Free article.
69 results