Cao D - Search Results

1

Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization.

Ren J, Li J, Wang Y, Chen W, Shen A, Liu H, Chen D, Cao D, Li Y, Zhang N, Xu Y, Geng M, He J, Xiong B, Shen J. Ren J, et al. Among authors: cao d. Bioorg Med Chem Lett. 2014 Jun 1;24(11):2525-9. doi: 10.1016/j.bmcl.2014.03.100. Epub 2014 Apr 8. Bioorg Med Chem Lett. 2014. PMID: 24751441

2

Fragment-based drug discovery of 2-thiazolidinones as inhibitors of the histone reader BRD4 bromodomain.

Zhao L, Cao D, Chen T, Wang Y, Miao Z, Xu Y, Chen W, Wang X, Li Y, Du Z, Xiong B, Li J, Xu C, Zhang N, He J, Shen J. Zhao L, et al. Among authors: cao d. J Med Chem. 2013 May 23;56(10):3833-51. doi: 10.1021/jm301793a. Epub 2013 May 14. J Med Chem. 2013. PMID: 23530754

3

Multi-substituted 8-aminoimidazo[1,2-a]pyrazines by Groebke-Blackburn-Bienaymé reaction and their Hsp90 inhibitory activity.

Ren J, Yang M, Liu H, Cao D, Chen D, Li J, Tang L, He J, Chen YL, Geng M, Xiong B, Shen J. Ren J, et al. Among authors: cao d. Org Biomol Chem. 2015 Feb 7;13(5):1531-5. doi: 10.1039/c4ob01865f. Org Biomol Chem. 2015. PMID: 25490978

4

Fragment-based drug discovery of 2-thiazolidinones as BRD4 inhibitors: 2. Structure-based optimization.

Zhao L, Wang Y, Cao D, Chen T, Wang Q, Li Y, Xu Y, Zhang N, Wang X, Chen D, Chen L, Chen YL, Xia G, Shi Z, Liu YC, Lin Y, Miao Z, Shen J, Xiong B. Zhao L, et al. Among authors: cao d. J Med Chem. 2015 Feb 12;58(3):1281-97. doi: 10.1021/jm501504k. Epub 2015 Jan 14. J Med Chem. 2015. PMID: 25559428

5

Discovery of a series of dihydroquinoxalin-2(1H)-ones as selective BET inhibitors from a dual PLK1-BRD4 inhibitor.

Hu J, Wang Y, Li Y, Xu L, Cao D, Song S, Damaneh MS, Wang X, Meng T, Chen YL, Shen J, Miao Z, Xiong B. Hu J, et al. Among authors: cao d. Eur J Med Chem. 2017 Sep 8;137:176-195. doi: 10.1016/j.ejmech.2017.05.049. Epub 2017 May 27. Eur J Med Chem. 2017. PMID: 28586718

6

Structure-based optimization of a series of selective BET inhibitors containing aniline or indoline groups.

Hu J, Wang Y, Li Y, Cao D, Xu L, Song S, Damaneh MS, Li J, Chen Y, Wang X, Chen L, Shen J, Miao Z, Xiong B. Hu J, et al. Among authors: cao d. Eur J Med Chem. 2018 Apr 25;150:156-175. doi: 10.1016/j.ejmech.2018.02.070. Epub 2018 Feb 24. Eur J Med Chem. 2018. PMID: 29525435

7

Fragment-based drug discovery of triazole inhibitors to block PDEδ-RAS protein-protein interaction.

Chen D, Chen Y, Lian F, Chen L, Li Y, Cao D, Wang X, Chen L, Li J, Meng T, Huang M, Geng M, Shen J, Zhang N, Xiong B. Chen D, et al. Among authors: cao d. Eur J Med Chem. 2019 Feb 1;163:597-609. doi: 10.1016/j.ejmech.2018.12.018. Epub 2018 Dec 11. Eur J Med Chem. 2019. PMID: 30562696

8

Design and Synthesis of Potent, Selective Inhibitors of Protein Arginine Methyltransferase 4 against Acute Myeloid Leukemia.

Guo Z, Zhang Z, Yang H, Cao D, Xu X, Zheng X, Chen D, Wang Q, Li Y, Li J, Du Z, Wang X, Chen L, Ding J, Shen J, Geng M, Huang X, Xiong B. Guo Z, et al. Among authors: cao d. J Med Chem. 2019 Jun 13;62(11):5414-5433. doi: 10.1021/acs.jmedchem.9b00297. Epub 2019 Jun 4. J Med Chem. 2019. PMID: 31117515

9

Structure-Based Discovery and Development of a Series of Potent and Selective Bromodomain and Extra-Terminal Protein Inhibitors.

Hu J, Tian CQ, Damaneh MS, Li Y, Cao D, Lv K, Yu T, Meng T, Chen D, Wang X, Chen L, Li J, Song SS, Huan XJ, Qin L, Shen J, Wang YQ, Miao ZH, Xiong B. Hu J, et al. Among authors: cao d. J Med Chem. 2019 Sep 26;62(18):8642-8663. doi: 10.1021/acs.jmedchem.9b01094. Epub 2019 Sep 16. J Med Chem. 2019. PMID: 31490070

10

Rational Design and Evaluation of 6-(Pyrimidin-2-ylamino)-3,4-dihydroquinoxalin-2(1H)-ones as Polypharmacological Inhibitors of BET and Kinases.

Lv K, Chen W, Chen D, Mou J, Zhang H, Fan T, Li Y, Cao D, Wang X, Chen L, Shen J, Pei D, Xiong B. Lv K, et al. Among authors: cao d. J Med Chem. 2020 Sep 10;63(17):9787-9802. doi: 10.1021/acs.jmedchem.0c00962. Epub 2020 Aug 26. J Med Chem. 2020. PMID: 32787081

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