He J - Search Results

1

Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization.

Ren J, Li J, Wang Y, Chen W, Shen A, Liu H, Chen D, Cao D, Li Y, Zhang N, Xu Y, Geng M, He J, Xiong B, Shen J. Ren J, et al. Among authors: he j. Bioorg Med Chem Lett. 2014 Jun 1;24(11):2525-9. doi: 10.1016/j.bmcl.2014.03.100. Epub 2014 Apr 8. Bioorg Med Chem Lett. 2014. PMID: 24751441

2

Determining the DUF55-domain structure of human thymocyte nuclear protein 1 from crystals partially twinned by tetartohedry.

Yu F, Song A, Xu C, Sun L, Li J, Tang L, Yu M, Yeates TO, Hu H, He J. Yu F, et al. Among authors: he j. Acta Crystallogr D Biol Crystallogr. 2009 Mar;65(Pt 3):212-9. doi: 10.1107/S0907444908041474. Epub 2009 Feb 20. Acta Crystallogr D Biol Crystallogr. 2009. PMID: 19237743

3

The sandwich method for protein crystallization and its effect on crystal growth.

Sun L, Li J, Xu C, Yu F, Zhou H, Tang L, He J. Sun L, et al. Among authors: he j. Acta Biochim Biophys Sin (Shanghai). 2010 May 15;42(5):332-6. doi: 10.1093/abbs/gmq027. Acta Biochim Biophys Sin (Shanghai). 2010. PMID: 20458446 Free article.

4

Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations.

Xu Y, Li MJ, Greenblatt H, Chen W, Paz A, Dym O, Peleg Y, Chen T, Shen X, He J, Jiang H, Silman I, Sussman JL. Xu Y, et al. Among authors: he j. Acta Crystallogr D Biol Crystallogr. 2012 Jan;68(Pt 1):13-25. doi: 10.1107/S0907444911047251. Epub 2011 Dec 9. Acta Crystallogr D Biol Crystallogr. 2012. PMID: 22194329

5

Structure insights into mechanisms of ATP hydrolysis and the activation of human heat-shock protein 90.

Li J, Sun L, Xu C, Yu F, Zhou H, Zhao Y, Zhang J, Cai J, Mao C, Tang L, Xu Y, He J. Li J, et al. Among authors: he j. Acta Biochim Biophys Sin (Shanghai). 2012 Apr;44(4):300-6. doi: 10.1093/abbs/gms001. Epub 2012 Feb 7. Acta Biochim Biophys Sin (Shanghai). 2012. PMID: 22318716 Free article.

6

Cyanobacterial peptides as a prototype for the design of potent β-secretase inhibitors and the development of selective chemical probes for other aspartic proteases.

Liu Y, Zhang W, Li L, Salvador LA, Chen T, Chen W, Felsenstein KM, Ladd TB, Price AR, Golde TE, He J, Xu Y, Li Y, Luesch H. Liu Y, et al. Among authors: he j. J Med Chem. 2012 Dec 13;55(23):10749-65. doi: 10.1021/jm301630s. Epub 2012 Nov 26. J Med Chem. 2012. PMID: 23181502

7

Fragment-based drug discovery of 2-thiazolidinones as inhibitors of the histone reader BRD4 bromodomain.

Zhao L, Cao D, Chen T, Wang Y, Miao Z, Xu Y, Chen W, Wang X, Li Y, Du Z, Xiong B, Li J, Xu C, Zhang N, He J, Shen J. Zhao L, et al. Among authors: he j. J Med Chem. 2013 May 23;56(10):3833-51. doi: 10.1021/jm301793a. Epub 2013 May 14. J Med Chem. 2013. PMID: 23530754

8

[Progress in the fragment-based drug discovery].

Ren J, Li J, Shi F, Wang X, He JH, Xu YC, Zhang NX, Xiong B, Shen JK. Ren J, et al. Among authors: he jh. Yao Xue Xue Bao. 2013 Jan;48(1):14-24. Yao Xue Xue Bao. 2013. PMID: 23600136 Review. Chinese.

9

The crystal structure of human GDP-L-fucose synthase.

Zhou H, Sun L, Li J, Xu C, Yu F, Liu Y, Ji C, He J. Zhou H, et al. Among authors: he j. Acta Biochim Biophys Sin (Shanghai). 2013 Sep;45(9):720-5. doi: 10.1093/abbs/gmt066. Epub 2013 Jun 16. Acta Biochim Biophys Sin (Shanghai). 2013. PMID: 23774504 Free article.

10

Discovery of pyrazole as C-terminus of selective BACE1 inhibitors.

Zou Y, Xu L, Chen W, Zhu Y, Chen T, Fu Y, Li L, Ma L, Xiong B, Wang X, Li J, He J, Zhang H, Xu Y, Li J, Shen J. Zou Y, et al. Among authors: he j. Eur J Med Chem. 2013 Oct;68:270-83. doi: 10.1016/j.ejmech.2013.06.027. Epub 2013 Jun 21. Eur J Med Chem. 2013. PMID: 23988410

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