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Antihelminthic benzimidazoles are novel HIF activators that prevent oxidative neuronal death via binding to tubulin.
Aleyasin H, Karuppagounder SS, Kumar A, Sleiman S, Basso M, Ma T, Siddiq A, Chinta SJ, Brochier C, Langley B, Haskew-Layton R, Bane SL, Riggins GJ, Gazaryan I, Starkov AA, Andersen JK, Ratan RR. Aleyasin H, et al. Among authors: chinta sj. Antioxid Redox Signal. 2015 Jan 10;22(2):121-34. doi: 10.1089/ars.2013.5595. Antioxid Redox Signal. 2015. PMID: 24766300 Free PMC article.
Dopaminergic neurons.
Chinta SJ, Andersen JK. Chinta SJ, et al. Int J Biochem Cell Biol. 2005 May;37(5):942-6. doi: 10.1016/j.biocel.2004.09.009. Epub 2004 Dec 2. Int J Biochem Cell Biol. 2005. PMID: 15743669 Review.
Redox imbalance in Parkinson's disease.
Chinta SJ, Andersen JK. Chinta SJ, et al. Biochim Biophys Acta. 2008 Nov;1780(11):1362-7. doi: 10.1016/j.bbagen.2008.02.005. Epub 2008 Mar 4. Biochim Biophys Acta. 2008. PMID: 18358848 Free PMC article. Review.
A disruption in iron-sulfur center biogenesis via inhibition of mitochondrial dithiol glutaredoxin 2 may contribute to mitochondrial and cellular iron dysregulation in mammalian glutathione-depleted dopaminergic cells: implications for Parkinson's disease.
Lee DW, Kaur D, Chinta SJ, Rajagopalan S, Andersen JK. Lee DW, et al. Among authors: chinta sj. Antioxid Redox Signal. 2009 Sep;11(9):2083-94. doi: 10.1089/ars.2009.2489. Antioxid Redox Signal. 2009. PMID: 19290777 Free PMC article.
52 results