Hobbs RM - Search Results

1

Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function.

Papa A, Wan L, Bonora M, Salmena L, Song MS, Hobbs RM, Lunardi A, Webster K, Ng C, Newton RH, Knoblauch N, Guarnerio J, Ito K, Turka LA, Beck AH, Pinton P, Bronson RT, Wei W, Pandolfi PP. Papa A, et al. Among authors: hobbs rm. Cell. 2014 Apr 24;157(3):595-610. doi: 10.1016/j.cell.2014.03.027. Cell. 2014. PMID: 24766807 Free PMC article.

2

Systemic elevation of PTEN induces a tumor-suppressive metabolic state.

Garcia-Cao I, Song MS, Hobbs RM, Laurent G, Giorgi C, de Boer VC, Anastasiou D, Ito K, Sasaki AT, Rameh L, Carracedo A, Vander Heiden MG, Cantley LC, Pinton P, Haigis MC, Pandolfi PP. Garcia-Cao I, et al. Among authors: hobbs rm. Cell. 2012 Mar 30;149(1):49-62. doi: 10.1016/j.cell.2012.02.030. Epub 2012 Mar 6. Cell. 2012. PMID: 22401813 Free PMC article.

3

Control of Glucocorticoid Receptor Levels by PTEN Establishes a Failsafe Mechanism for Tumor Suppression.

Yip HYK, Chee A, Ang CS, Shin SY, Ooms LM, Mohammadi Z, Phillips WA, Daly RJ, Cole TJ, Bronson RT, Nguyen LK, Tiganis T, Hobbs RM, McLean CA, Mitchell CA, Papa A. Yip HYK, et al. Among authors: hobbs rm. Mol Cell. 2020 Oct 15;80(2):279-295.e8. doi: 10.1016/j.molcel.2020.09.027. Mol Cell. 2020. PMID: 33065020 Free article.

4

Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation.

Poliseno L, Salmena L, Riccardi L, Fornari A, Song MS, Hobbs RM, Sportoletti P, Varmeh S, Egia A, Fedele G, Rameh L, Loda M, Pandolfi PP. Poliseno L, et al. Among authors: hobbs rm. Sci Signal. 2010 Apr 13;3(117):ra29. doi: 10.1126/scisignal.2000594. Sci Signal. 2010. PMID: 20388916 Free PMC article.

5

Plzf regulates germline progenitor self-renewal by opposing mTORC1.

Hobbs RM, Seandel M, Falciatori I, Rafii S, Pandolfi PP. Hobbs RM, et al. Cell. 2010 Aug 6;142(3):468-79. doi: 10.1016/j.cell.2010.06.041. Cell. 2010. PMID: 20691905 Free PMC article.

6

Functional antagonism between Sall4 and Plzf defines germline progenitors.

Hobbs RM, Fagoonee S, Papa A, Webster K, Altruda F, Nishinakamura R, Chai L, Pandolfi PP. Hobbs RM, et al. Cell Stem Cell. 2012 Mar 2;10(3):284-98. doi: 10.1016/j.stem.2012.02.004. Cell Stem Cell. 2012. PMID: 22385656 Free PMC article.

7

Vulnerabilities of PTEN-TP53-deficient prostate cancers to compound PARP-PI3K inhibition.

González-Billalabeitia E, Seitzer N, Song SJ, Song MS, Patnaik A, Liu XS, Epping MT, Papa A, Hobbs RM, Chen M, Lunardi A, Ng C, Webster KA, Signoretti S, Loda M, Asara JM, Nardella C, Clohessy JG, Cantley LC, Pandolfi PP. González-Billalabeitia E, et al. Among authors: hobbs rm. Cancer Discov. 2014 Aug;4(8):896-904. doi: 10.1158/2159-8290.CD-13-0230. Epub 2014 May 27. Cancer Discov. 2014. PMID: 24866151 Free PMC article.

8

Suppression of CHK1 by ETS Family Members Promotes DNA Damage Response Bypass and Tumorigenesis.

Lunardi A, Varmeh S, Chen M, Taulli R, Guarnerio J, Ala U, Seitzer N, Ishikawa T, Carver BS, Hobbs RM, Quarantotti V, Ng C, Berger AH, Nardella C, Poliseno L, Montironi R, Castillo-Martin M, Cordon-Cardo C, Signoretti S, Pandolfi PP. Lunardi A, et al. Among authors: hobbs rm. Cancer Discov. 2015 May;5(5):550-63. doi: 10.1158/2159-8290.CD-13-1050. Epub 2015 Feb 4. Cancer Discov. 2015. PMID: 25653093 Free PMC article.

9

Shape-shifting and tumor suppression by PLZF.

Hobbs RM, Pandolfi PP. Hobbs RM, et al. Oncotarget. 2010 May;1(1):3-5. doi: 10.18632/oncotarget.102. Oncotarget. 2010. PMID: 21293049 Free PMC article. No abstract available.

10

A genetic platform to model sarcomagenesis from primary adult mesenchymal stem cells.

Guarnerio J, Riccardi L, Taulli R, Maeda T, Wang G, Hobbs RM, Song MS, Sportoletti P, Bernardi R, Bronson RT, Castillo-Martin M, Cordon-Cardo C, Lunardi A, Pandolfi PP. Guarnerio J, et al. Among authors: hobbs rm. Cancer Discov. 2015 Apr;5(4):396-409. doi: 10.1158/2159-8290.CD-14-1022. Epub 2015 Jan 22. Cancer Discov. 2015. PMID: 25614485 Free PMC article.

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