Eastman A - Search Results

1

Gossypol increases expression of the pro-apoptotic BH3-only protein NOXA through a novel mechanism involving phospholipase A2, cytoplasmic calcium, and endoplasmic reticulum stress.

Soderquist RS, Danilov AV, Eastman A. Soderquist RS, et al. Among authors: eastman a. J Biol Chem. 2014 Jun 6;289(23):16190-9. doi: 10.1074/jbc.M114.562900. Epub 2014 Apr 28. J Biol Chem. 2014. PMID: 24778183 Free PMC article.

2

The novel triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) potently enhances apoptosis induced by tumor necrosis factor in human leukemia cells.

Stadheim TA, Suh N, Ganju N, Sporn MB, Eastman A. Stadheim TA, et al. Among authors: eastman a. J Biol Chem. 2002 May 10;277(19):16448-55. doi: 10.1074/jbc.M108974200. Epub 2002 Mar 5. J Biol Chem. 2002. PMID: 11880365 Free article.

3

Abrogation of the S phase DNA damage checkpoint results in S phase progression or premature mitosis depending on the concentration of 7-hydroxystaurosporine and the kinetics of Cdc25C activation.

Kohn EA, Ruth ND, Brown MK, Livingstone M, Eastman A. Kohn EA, et al. Among authors: eastman a. J Biol Chem. 2002 Jul 19;277(29):26553-64. doi: 10.1074/jbc.M202040200. Epub 2002 Apr 12. J Biol Chem. 2002. PMID: 11953432 Free article.

4

Multiple BH3 mimetics antagonize antiapoptotic MCL1 protein by inducing the endoplasmic reticulum stress response and up-regulating BH3-only protein NOXA.

Albershardt TC, Salerni BL, Soderquist RS, Bates DJ, Pletnev AA, Kisselev AF, Eastman A. Albershardt TC, et al. Among authors: eastman a. J Biol Chem. 2011 Jul 15;286(28):24882-95. doi: 10.1074/jbc.M111.255828. Epub 2011 May 31. J Biol Chem. 2011. PMID: 21628457 Free PMC article.

5

Vinblastine sensitizes leukemia cells to cyclin-dependent kinase inhibitors, inducing acute cell cycle phase-independent apoptosis.

Bates DJ, Salerni BL, Lowrey CH, Eastman A. Bates DJ, et al. Among authors: eastman a. Cancer Biol Ther. 2011 Aug 15;12(4):314-25. doi: 10.4161/cbt.12.4.16909. Epub 2011 Aug 15. Cancer Biol Ther. 2011. PMID: 21768777 Free PMC article.

6

Gossypol overcomes stroma-mediated resistance to the BCL2 inhibitor ABT-737 in chronic lymphocytic leukemia cells ex vivo.

Soderquist R, Bates DJ, Danilov AV, Eastman A. Soderquist R, et al. Among authors: eastman a. Leukemia. 2013 Nov;27(11):2262-4. doi: 10.1038/leu.2013.138. Epub 2013 May 3. Leukemia. 2013. PMID: 23640104 Free PMC article. No abstract available.

7

Vinblastine rapidly induces NOXA and acutely sensitizes primary chronic lymphocytic leukemia cells to ABT-737.

Bates DJ, Danilov AV, Lowrey CH, Eastman A. Bates DJ, et al. Among authors: eastman a. Mol Cancer Ther. 2013 Aug;12(8):1504-14. doi: 10.1158/1535-7163.MCT-12-1197. Epub 2013 May 30. Mol Cancer Ther. 2013. PMID: 23723123 Free PMC article.

8

Toward a cure for chronic lymphocytic leukemia: an attack on multiple fronts.

Danilov AV, Soderquist RS, Bates DJ, Eastman A. Danilov AV, et al. Among authors: eastman a. Expert Rev Anticancer Ther. 2013 Sep;13(9):1009-12. doi: 10.1586/14737140.2013.825424. Expert Rev Anticancer Ther. 2013. PMID: 24053199 Free PMC article. No abstract available.

9

The putative BH3 mimetic S1 sensitizes leukemia to ABT-737 by increasing reactive oxygen species, inducing endoplasmic reticulum stress, and upregulating the BH3-only protein NOXA.

Soderquist R, Pletnev AA, Danilov AV, Eastman A. Soderquist R, et al. Among authors: eastman a. Apoptosis. 2014 Jan;19(1):201-9. doi: 10.1007/s10495-013-0910-y. Apoptosis. 2014. PMID: 24072590 Free PMC article.

10

The Nedd8-activating enzyme inhibitor MLN4924 thwarts microenvironment-driven NF-κB activation and induces apoptosis in chronic lymphocytic leukemia B cells.

Godbersen JC, Humphries LA, Danilova OV, Kebbekus PE, Brown JR, Eastman A, Danilov AV. Godbersen JC, et al. Among authors: eastman a. Clin Cancer Res. 2014 Mar 15;20(6):1576-89. doi: 10.1158/1078-0432.CCR-13-0987. Clin Cancer Res. 2014. PMID: 24634471 Free PMC article.

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