Xu Z - Search Results

1

Global CNS transduction of adult mice by intravenously delivered rAAVrh.8 and rAAVrh.10 and nonhuman primates by rAAVrh.10.

Yang B, Li S, Wang H, Guo Y, Gessler DJ, Cao C, Su Q, Kramer J, Zhong L, Ahmed SS, Zhang H, He R, Desrosiers RC, Brown R, Xu Z, Gao G. Yang B, et al. Among authors: xu z. Mol Ther. 2014 Jul;22(7):1299-1309. doi: 10.1038/mt.2014.68. Epub 2014 Apr 30. Mol Ther. 2014. PMID: 24781136 Free PMC article.

2

Several rAAV vectors efficiently cross the blood-brain barrier and transduce neurons and astrocytes in the neonatal mouse central nervous system.

Zhang H, Yang B, Mu X, Ahmed SS, Su Q, He R, Wang H, Mueller C, Sena-Esteves M, Brown R, Xu Z, Gao G. Zhang H, et al. Among authors: xu z. Mol Ther. 2011 Aug;19(8):1440-8. doi: 10.1038/mt.2011.98. Epub 2011 May 24. Mol Ther. 2011. PMID: 21610699 Free PMC article.

3

Widespread spinal cord transduction by intrathecal injection of rAAV delivers efficacious RNAi therapy for amyotrophic lateral sclerosis.

Wang H, Yang B, Qiu L, Yang C, Kramer J, Su Q, Guo Y, Brown RH Jr, Gao G, Xu Z. Wang H, et al. Among authors: xu z. Hum Mol Genet. 2014 Feb 1;23(3):668-81. doi: 10.1093/hmg/ddt454. Epub 2013 Sep 18. Hum Mol Genet. 2014. PMID: 24108104 Free PMC article.

4

Systemic AAV9 gene transfer in adult GM1 gangliosidosis mice reduces lysosomal storage in CNS and extends lifespan.

Weismann CM, Ferreira J, Keeler AM, Su Q, Qui L, Shaffer SA, Xu Z, Gao G, Sena-Esteves M. Weismann CM, et al. Among authors: xu z. Hum Mol Genet. 2015 Aug 1;24(15):4353-64. doi: 10.1093/hmg/ddv168. Epub 2015 May 10. Hum Mol Genet. 2015. PMID: 25964428 Free PMC article.

5

A Single Injection of Recombinant Adeno-Associated Virus into the Lumbar Cistern Delivers Transgene Expression Throughout the Whole Spinal Cord.

Guo Y, Wang D, Qiao T, Yang C, Su Q, Gao G, Xu Z. Guo Y, et al. Among authors: xu z. Mol Neurobiol. 2016 Jul;53(5):3235-3248. doi: 10.1007/s12035-015-9223-1. Epub 2015 Jun 7. Mol Neurobiol. 2016. PMID: 26050084 Free PMC article.

6

Slow Intrathecal Injection of rAAVrh10 Enhances its Transduction of Spinal Cord and Therapeutic Efficacy in a Mutant SOD1 Model of ALS.

Li D, Liu C, Yang C, Wang D, Wu D, Qi Y, Su Q, Gao G, Xu Z, Guo Y. Li D, et al. Among authors: xu z. Neuroscience. 2017 Dec 4;365:192-205. doi: 10.1016/j.neuroscience.2017.10.001. Epub 2017 Oct 9. Neuroscience. 2017. PMID: 29024785 Free PMC article.

7

Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis.

Yang C, Wang H, Qiao T, Yang B, Aliaga L, Qiu L, Tan W, Salameh J, McKenna-Yasek DM, Smith T, Peng L, Moore MJ, Brown RH Jr, Cai H, Xu Z. Yang C, et al. Among authors: xu z. Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):E1121-9. doi: 10.1073/pnas.1322641111. Epub 2014 Mar 10. Proc Natl Acad Sci U S A. 2014. PMID: 24616503 Free PMC article.

8

Direct Intrathecal Injection of Recombinant Adeno-associated Viruses in Adult Mice.

Li D, Li Y, Tian Y, Xu Z, Guo Y. Li D, et al. Among authors: xu z. J Vis Exp. 2019 Feb 15;(144). doi: 10.3791/58565. J Vis Exp. 2019. PMID: 30829325

9

Nerve injection of viral vectors efficiently transfers transgenes into motor neurons and delivers RNAi therapy against ALS.

Wu R, Wang H, Xia X, Zhou H, Liu C, Castro M, Xu Z. Wu R, et al. Among authors: xu z. Antioxid Redox Signal. 2009 Jul;11(7):1523-34. doi: 10.1089/ars.2009.2618. Antioxid Redox Signal. 2009. PMID: 19344276 Free PMC article.

10

Widespread aggregation of mutant VAPB associated with ALS does not cause motor neuron degeneration or modulate mutant SOD1 aggregation and toxicity in mice.

Qiu L, Qiao T, Beers M, Tan W, Wang H, Yang B, Xu Z. Qiu L, et al. Among authors: xu z. Mol Neurodegener. 2013 Jan 3;8:1. doi: 10.1186/1750-1326-8-1. Mol Neurodegener. 2013. PMID: 23281774 Free PMC article.

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