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Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300.
Majmudar CY, Højfeldt JW, Arevang CJ, Pomerantz WC, Gagnon JK, Schultz PJ, Cesa LC, Doss CH, Rowe SP, Vásquez V, Tamayo-Castillo G, Cierpicki T, Brooks CL 3rd, Sherman DH, Mapp AK. Majmudar CY, et al. Among authors: mapp ak. Angew Chem Int Ed Engl. 2012 Nov 5;51(45):11258-62. doi: 10.1002/anie.201206815. Epub 2012 Oct 8. Angew Chem Int Ed Engl. 2012. PMID: 23042634 Free PMC article.
Ordering a dynamic protein via a small-molecule stabilizer.
Wang N, Majmudar CY, Pomerantz WC, Gagnon JK, Sadowsky JD, Meagher JL, Johnson TK, Stuckey JA, Brooks CL 3rd, Wells JA, Mapp AK. Wang N, et al. Among authors: mapp ak. J Am Chem Soc. 2013 Mar 6;135(9):3363-6. doi: 10.1021/ja3122334. Epub 2013 Feb 22. J Am Chem Soc. 2013. PMID: 23384013 Free PMC article.
Covalent Chemical Cochaperones of the p300/CBP GACKIX Domain.
Lodge JM, Majmudar CY, Clayton J, Mapp AK. Lodge JM, et al. Among authors: mapp ak. Chembiochem. 2018 Sep 17;19(18):1907-1912. doi: 10.1002/cbic.201800173. Epub 2018 Sep 5. Chembiochem. 2018. PMID: 29939485 Free PMC article.
Conservation of coactivator engagement mechanism enables small-molecule allosteric modulators.
Henderson AR, Henley MJ, Foster NJ, Peiffer AL, Beyersdorf MS, Stanford KD, Sturlis SM, Linhares BM, Hill ZB, Wells JA, Cierpicki T, Brooks CL 3rd, Fierke CA, Mapp AK. Henderson AR, et al. Among authors: mapp ak. Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):8960-8965. doi: 10.1073/pnas.1806202115. Epub 2018 Aug 20. Proc Natl Acad Sci U S A. 2018. PMID: 30127017 Free PMC article.
93 results