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Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2.
Scott DC, Dharuman S, Griffith E, Chai SC, Ronnebaum J, King MT, Tangallapally R, Lee C, Gee CT, Yang L, Li Y, Loudon VC, Lee HW, Ochoada J, Miller DJ, Jayasinghe T, Paulo JA, Elledge SJ, Harper JW, Chen T, Lee RE, Schulman BA. Scott DC, et al. Among authors: lee re. Nat Commun. 2024 Oct 12;15(1):8829. doi: 10.1038/s41467-024-52966-3. Nat Commun. 2024. PMID: 39396041 Free PMC article.
Correction: Synthesis and antibacterial action of 3',6'-disubstituted spectinomycins.
Dharuman S, Phelps GA, Dunn CM, Wilt LA, Murphy PA, Lee RB, Snoke HE, Selchow P, Haldimann K, Böttger EC, Hobbie SN, Sander P, Lee RE. Dharuman S, et al. Among authors: lee re. J Antibiot (Tokyo). 2024 Oct 11. doi: 10.1038/s41429-024-00777-5. Online ahead of print. J Antibiot (Tokyo). 2024. PMID: 39394258 No abstract available.
Spectinamide MBX-4888A exhibits favorable lesion and tissue distribution and promotes treatment shortening in advanced murine models of tuberculosis.
Bauman AA, Sarathy JP, Kaya F, Massoudi LM, Scherman MS, Hastings C, Liu J, Xie M, Brooks EJ, Ramey ME, Jones IL, Benedict ND, Maclaughlin MR, Miller-Dawson JA, Waidyarachchi SL, Butler MM, Bowlin TL, Zimmerman MD, Lenaerts AJ, Meibohm B, Gonzalez-Juarrero M, Lyons MA, Dartois V, Lee RE, Robertson GT. Bauman AA, et al. Among authors: lee re. Antimicrob Agents Chemother. 2024 Nov 6;68(11):e0071624. doi: 10.1128/aac.00716-24. Epub 2024 Sep 30. Antimicrob Agents Chemother. 2024. PMID: 39345140 Free PMC article.
Chemical genetic analysis of enoxolone inhibition of Clostridioides difficile toxin production reveals adenine deaminase and ATP synthase as antivirulence targets.
Marreddy RKR, Phelps GA, Churion K, Picker J, Powell R, Cherian PT, Bowling JJ, Stephan CC, Lee RE, Hurdle JG. Marreddy RKR, et al. Among authors: lee re. J Biol Chem. 2024 Nov;300(11):107839. doi: 10.1016/j.jbc.2024.107839. Epub 2024 Sep 27. J Biol Chem. 2024. PMID: 39343002 Free PMC article.
Enhancing the therapeutic window for Spectinamide anti-tuberculosis Agents: Synthesis, Evaluation, and activation of phosphate prodrug 3408.
Liu J, Lukka PB, Ektnitphong VA, Parmar KR, Wagh S, Lu Y, Lee RB, Scherbakov D, Wang H, Zimmerman MD, Meibohm B, Robertson GT, Dartois V, Böttger EC, Lenaerts AJ, Lee RE. Liu J, et al. Among authors: lee re. Bioorg Med Chem Lett. 2024 Nov 1;112:129934. doi: 10.1016/j.bmcl.2024.129934. Epub 2024 Aug 28. Bioorg Med Chem Lett. 2024. PMID: 39214506 Free article.
Development of Brain Penetrant Pyridazine Pantothenate Kinase Activators.
Tangallapally R, Subramanian C, Yun MK, Edwards A, Sharma LK, Yang L, Creed K, Wang J, Jackowski S, Rock CO, White SW, Lee RE. Tangallapally R, et al. Among authors: lee re. J Med Chem. 2024 Aug 22;67(16):14432-14442. doi: 10.1021/acs.jmedchem.4c01211. Epub 2024 Aug 13. J Med Chem. 2024. PMID: 39136313 Free PMC article.
901 results