Mish MR - Search Results

1

Preparation and biological evaluation of 1'-cyano-2'-C-methyl pyrimidine nucleosides as HCV NS5B polymerase inhibitors.

Mish MR, Cho A, Kirschberg T, Xu J, Zonte CS, Fenaux M, Park Y, Babusis D, Feng JY, Ray AS, Kim CU. Mish MR, et al. Bioorg Med Chem Lett. 2014 Jul 15;24(14):3092-5. doi: 10.1016/j.bmcl.2014.05.015. Epub 2014 May 22. Bioorg Med Chem Lett. 2014. PMID: 24907145

2

Synthesis and characterization of 1'-C-cyano-2'-fluoro-2'-C-methyl pyrimidine nucleosides as HCV polymerase inhibitors.

Kirschberg TA, Mish MR, Zhang L, Squires NH, Wang KY, Cho A, Feng JY, Fenaux M, Babusis D, Park Y, Ray AS, Kim CU. Kirschberg TA, et al. Among authors: mish mr. Bioorg Med Chem Lett. 2015 Mar 1;25(5):1040-3. doi: 10.1016/j.bmcl.2015.01.021. Epub 2015 Jan 17. Bioorg Med Chem Lett. 2015. PMID: 25650256

3

Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties.

Kirschberg TA, Metobo S, Clarke MO, Aktoudianakis V, Babusis D, Barauskas O, Birkus G, Butler T, Byun D, Chin G, Doerffler E, Edwards TE, Fenaux M, Lee R, Lew W, Mish MR, Murakami E, Park Y, Squires NH, Tirunagari N, Wang T, Whitcomb M, Xu J, Yang H, Ye H, Zhang L, Appleby TC, Feng JY, Ray AS, Cho A, Kim CU. Kirschberg TA, et al. Among authors: mish mr. Bioorg Med Chem Lett. 2017 Apr 15;27(8):1840-1847. doi: 10.1016/j.bmcl.2017.02.037. Epub 2017 Feb 20. Bioorg Med Chem Lett. 2017. PMID: 28274633

4

Synthesis of 1'-C-cyano pyrimidine nucleosides and characterization as HCV polymerase inhibitors.

Kirschberg TA, Mish M, Squires NH, Zonte S, Aktoudianakis E, Metobo S, Butler T, Ju X, Cho A, Ray AS, Kim CU. Kirschberg TA, et al. Nucleosides Nucleotides Nucleic Acids. 2015;34(11):763-85. doi: 10.1080/15257770.2015.1075550. Epub 2015 Sep 23. Nucleosides Nucleotides Nucleic Acids. 2015. PMID: 26398773

5

Highly potent HCV NS4B inhibitors with activity against multiple genotypes.

Phillips B, Cai R, Delaney W, Du Z, Ji M, Jin H, Lee J, Li J, Niedziela-Majka A, Mish M, Pyun HJ, Saugier J, Tirunagari N, Wang J, Yang H, Wu Q, Sheng C, Zonte C. Phillips B, et al. J Med Chem. 2014 Mar 13;57(5):2161-6. doi: 10.1021/jm401646w. Epub 2014 Feb 18. J Med Chem. 2014. PMID: 24512292

6

Effect of substitution on novel tricyclic HIV-1 integrase inhibitors.

Fardis M, Jin H, Jabri S, Cai RZ, Mish M, Tsiang M, Kim CU. Fardis M, et al. Bioorg Med Chem Lett. 2006 Aug 1;16(15):4031-5. doi: 10.1016/j.bmcl.2006.05.008. Epub 2006 May 23. Bioorg Med Chem Lett. 2006. PMID: 16716589

7

Tricyclic HIV integrase inhibitors: VI. SAR studies of 'benzyl flipped' C3-substituted pyrroloquinolines.

Metobo S, Mish M, Jin H, Jabri S, Lansdown R, Chen X, Tsiang M, Wright M, Kim CU. Metobo S, et al. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1187-90. doi: 10.1016/j.bmcl.2008.12.079. Epub 2008 Dec 25. Bioorg Med Chem Lett. 2009. PMID: 19167883

8

Tricyclic HIV integrase inhibitors V. SAR studies on the benzyl moiety.

Jin H, Metobo S, Jabri S, Mish M, Lansdown R, Chen X, Tsiang M, Wright M, Kim CU. Jin H, et al. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2263-5. doi: 10.1016/j.bmcl.2009.02.092. Epub 2009 Feb 27. Bioorg Med Chem Lett. 2009. PMID: 19285389

9

Tricyclic HIV integrase inhibitors: potent and orally bioavailable C5-aza analogs.

Jin H, Wright M, Pastor R, Mish M, Metobo S, Jabri S, Lansdown R, Cai R, Pyun P, Tsiang M, Chen X, Kim CU. Jin H, et al. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1388-91. doi: 10.1016/j.bmcl.2008.01.018. Epub 2008 Jan 9. Bioorg Med Chem Lett. 2008. PMID: 18207398

10

Discovery of a Potent and Orally Bioavailable Cyclophilin Inhibitor Derived from the Sanglifehrin Macrocycle.

Mackman RL, Steadman VA, Dean DK, Jansa P, Poullennec KG, Appleby T, Austin C, Blakemore CA, Cai R, Cannizzaro C, Chin G, Chiva JC, Dunbar NA, Fliri H, Highton AJ, Hui H, Ji M, Jin H, Karki K, Keats AJ, Lazarides L, Lee YJ, Liclican A, Mish M, Murray B, Pettit SB, Pyun P, Sangi M, Santos R, Sanvoisin J, Schmitz U, Schrier A, Siegel D, Sperandio D, Stepan G, Tian Y, Watt GM, Yang H, Schultz BE. Mackman RL, et al. J Med Chem. 2018 Nov 8;61(21):9473-9499. doi: 10.1021/acs.jmedchem.8b00802. Epub 2018 Aug 22. J Med Chem. 2018. PMID: 30074795

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