Ray AS - Search Results

1

Preparation and biological evaluation of 1'-cyano-2'-C-methyl pyrimidine nucleosides as HCV NS5B polymerase inhibitors.

Mish MR, Cho A, Kirschberg T, Xu J, Zonte CS, Fenaux M, Park Y, Babusis D, Feng JY, Ray AS, Kim CU. Mish MR, et al. Among authors: ray as. Bioorg Med Chem Lett. 2014 Jul 15;24(14):3092-5. doi: 10.1016/j.bmcl.2014.05.015. Epub 2014 May 22. Bioorg Med Chem Lett. 2014. PMID: 24907145

2

Synthesis, anti-HIV activity, and resistance profiles of ribose modified nucleoside phosphonates.

Mackman RL, Boojamra CG, Prasad V, Zhang L, Lin KY, Petrakovsky O, Babusis D, Chen J, Douglas J, Grant D, Hui HC, Kim CU, Markevitch DY, Vela J, Ray A, Cihlar T. Mackman RL, et al. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6785-9. doi: 10.1016/j.bmcl.2007.10.038. Epub 2007 Oct 17. Bioorg Med Chem Lett. 2007. PMID: 18029175

3

Synthesis and antiviral activity of a series of 1'-substituted 4-aza-7,9-dideazaadenosine C-nucleosides.

Cho A, Saunders OL, Butler T, Zhang L, Xu J, Vela JE, Feng JY, Ray AS, Kim CU. Cho A, et al. Among authors: ray as. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2705-7. doi: 10.1016/j.bmcl.2012.02.105. Epub 2012 Mar 8. Bioorg Med Chem Lett. 2012. PMID: 22446091 Free PMC article.

4

Synthesis and characterization of 2'-C-Me branched C-nucleosides as HCV polymerase inhibitors.

Cho A, Zhang L, Xu J, Babusis D, Butler T, Lee R, Saunders OL, Wang T, Parrish J, Perry J, Feng JY, Ray AS, Kim CU. Cho A, et al. Among authors: ray as. Bioorg Med Chem Lett. 2012 Jun 15;22(12):4127-32. doi: 10.1016/j.bmcl.2012.04.065. Epub 2012 Apr 20. Bioorg Med Chem Lett. 2012. PMID: 22578461

5

Discovery of the first C-nucleoside HCV polymerase inhibitor (GS-6620) with demonstrated antiviral response in HCV infected patients.

Cho A, Zhang L, Xu J, Lee R, Butler T, Metobo S, Aktoudianakis V, Lew W, Ye H, Clarke M, Doerffler E, Byun D, Wang T, Babusis D, Carey AC, German P, Sauer D, Zhong W, Rossi S, Fenaux M, McHutchison JG, Perry J, Feng J, Ray AS, Kim CU. Cho A, et al. Among authors: ray as. J Med Chem. 2014 Mar 13;57(5):1812-25. doi: 10.1021/jm400201a. Epub 2013 May 1. J Med Chem. 2014. PMID: 23547794

6

Evaluation of 2'-α-fluorine modified nucleoside phosphonates as potential inhibitors of HCV polymerase.

Parrish JP, Lee SK, Boojamra CG, Hui H, Babusis D, Brown B, Shih IH, Feng JY, Ray AS, Mackman RL. Parrish JP, et al. Among authors: ray as. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3354-7. doi: 10.1016/j.bmcl.2013.03.095. Epub 2013 Apr 2. Bioorg Med Chem Lett. 2013. PMID: 23639543

7

Synthesis and characterization of 1'-C-cyano-2'-fluoro-2'-C-methyl pyrimidine nucleosides as HCV polymerase inhibitors.

Kirschberg TA, Mish MR, Zhang L, Squires NH, Wang KY, Cho A, Feng JY, Fenaux M, Babusis D, Park Y, Ray AS, Kim CU. Kirschberg TA, et al. Among authors: ray as. Bioorg Med Chem Lett. 2015 Mar 1;25(5):1040-3. doi: 10.1016/j.bmcl.2015.01.021. Epub 2015 Jan 17. Bioorg Med Chem Lett. 2015. PMID: 25650256

8

Synthesis of 1'-C-cyano pyrimidine nucleosides and characterization as HCV polymerase inhibitors.

Kirschberg TA, Mish M, Squires NH, Zonte S, Aktoudianakis E, Metobo S, Butler T, Ju X, Cho A, Ray AS, Kim CU. Kirschberg TA, et al. Among authors: ray as. Nucleosides Nucleotides Nucleic Acids. 2015;34(11):763-85. doi: 10.1080/15257770.2015.1075550. Epub 2015 Sep 23. Nucleosides Nucleotides Nucleic Acids. 2015. PMID: 26398773

9

Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties.

Kirschberg TA, Metobo S, Clarke MO, Aktoudianakis V, Babusis D, Barauskas O, Birkus G, Butler T, Byun D, Chin G, Doerffler E, Edwards TE, Fenaux M, Lee R, Lew W, Mish MR, Murakami E, Park Y, Squires NH, Tirunagari N, Wang T, Whitcomb M, Xu J, Yang H, Ye H, Zhang L, Appleby TC, Feng JY, Ray AS, Cho A, Kim CU. Kirschberg TA, et al. Among authors: ray as. Bioorg Med Chem Lett. 2017 Apr 15;27(8):1840-1847. doi: 10.1016/j.bmcl.2017.02.037. Epub 2017 Feb 20. Bioorg Med Chem Lett. 2017. PMID: 28274633

10

HCV RdRp, sofosbuvir and beyond.

Feng JY, Ray AS. Feng JY, et al. Among authors: ray as. Enzymes. 2021;49:63-82. doi: 10.1016/bs.enz.2021.06.003. Epub 2021 Sep 24. Enzymes. 2021. PMID: 34696839

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