Hong C - Search Results

1

Transgenic expression of dominant-active IDOL in liver causes diet-induced hypercholesterolemia and atherosclerosis in mice.

Calkin AC, Lee SD, Kim J, Van Stijn CM, Wu XH, Lusis AJ, Hong C, Tangirala RI, Tontonoz P. Calkin AC, et al. Among authors: hong c. Circ Res. 2014 Aug 1;115(4):442-9. doi: 10.1161/CIRCRESAHA.115.304440. Epub 2014 Jun 16. Circ Res. 2014. PMID: 24935961 Free PMC article.

2

LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor.

Zelcer N, Hong C, Boyadjian R, Tontonoz P. Zelcer N, et al. Among authors: hong c. Science. 2009 Jul 3;325(5936):100-4. doi: 10.1126/science.1168974. Epub 2009 Jun 11. Science. 2009. PMID: 19520913 Free PMC article.

3

The LXR-Idol axis differentially regulates plasma LDL levels in primates and mice.

Hong C, Marshall SM, McDaniel AL, Graham M, Layne JD, Cai L, Scotti E, Boyadjian R, Kim J, Chamberlain BT, Tangirala RK, Jung ME, Fong L, Lee R, Young SG, Temel RE, Tontonoz P. Hong C, et al. Cell Metab. 2014 Nov 4;20(5):910-918. doi: 10.1016/j.cmet.2014.10.001. Epub 2014 Nov 4. Cell Metab. 2014. PMID: 25440061 Free PMC article.

4

IDOL regulates systemic energy balance through control of neuronal VLDLR expression.

Lee SD, Priest C, Bjursell M, Gao J, Arneson DV, Ahn IS, Diamante G, van Veen JE, Massa MG, Calkin AC, Kim J, Andersén H, Rajbhandari P, Porritt M, Carreras A, Ahnmark A, Seeliger F, Maxvall I, Eliasson P, Althage M, Åkerblad P, Lindén D, Cole TA, Lee R, Boyd H, Bohlooly-Y M, Correa SM, Yang X, Tontonoz P, Hong C. Lee SD, et al. Among authors: hong c. Nat Metab. 2019 Nov;1(11):1089-1100. doi: 10.1038/s42255-019-0127-7. Epub 2019 Oct 28. Nat Metab. 2019. PMID: 32072135 Free PMC article.

5

Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE.

Bradley MN, Hong C, Chen M, Joseph SB, Wilpitz DC, Wang X, Lusis AJ, Collins A, Hseuh WA, Collins JL, Tangirala RK, Tontonoz P. Bradley MN, et al. Among authors: hong c. J Clin Invest. 2007 Aug;117(8):2337-46. doi: 10.1172/JCI31909. J Clin Invest. 2007. PMID: 17657314 Free PMC article.

6

Coordination of inflammation and metabolism by PPAR and LXR nuclear receptors.

Hong C, Tontonoz P. Hong C, et al. Curr Opin Genet Dev. 2008 Oct;18(5):461-7. doi: 10.1016/j.gde.2008.07.016. Epub 2008 Sep 7. Curr Opin Genet Dev. 2008. PMID: 18782619 Free PMC article. Review.

7

The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2.

Hong C, Duit S, Jalonen P, Out R, Scheer L, Sorrentino V, Boyadjian R, Rodenburg KW, Foley E, Korhonen L, Lindholm D, Nimpf J, van Berkel TJ, Tontonoz P, Zelcer N. Hong C, et al. J Biol Chem. 2010 Jun 25;285(26):19720-6. doi: 10.1074/jbc.M110.123729. Epub 2010 Apr 28. J Biol Chem. 2010. PMID: 20427281 Free PMC article.

8

Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease.

Beaven SW, Wroblewski K, Wang J, Hong C, Bensinger S, Tsukamoto H, Tontonoz P. Beaven SW, et al. Among authors: hong c. Gastroenterology. 2011 Mar;140(3):1052-62. doi: 10.1053/j.gastro.2010.11.053. Epub 2010 Dec 4. Gastroenterology. 2011. PMID: 21134374 Free PMC article.

9

Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target.

Hong C, Walczak R, Dhamko H, Bradley MN, Marathe C, Boyadjian R, Salazar JV, Tontonoz P. Hong C, et al. J Lipid Res. 2011 Mar;52(3):531-9. doi: 10.1194/jlr.M010686. Epub 2010 Dec 27. J Lipid Res. 2011. PMID: 21187453 Free PMC article.

10

Targeted disruption of the idol gene alters cellular regulation of the low-density lipoprotein receptor by sterols and liver x receptor agonists.

Scotti E, Hong C, Yoshinaga Y, Tu Y, Hu Y, Zelcer N, Boyadjian R, de Jong PJ, Young SG, Fong LG, Tontonoz P. Scotti E, et al. Among authors: hong c. Mol Cell Biol. 2011 May;31(9):1885-93. doi: 10.1128/MCB.01469-10. Epub 2011 Feb 22. Mol Cell Biol. 2011. PMID: 21343340 Free PMC article.

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