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Discovery of dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) inhibitors using an artificial intelligence model and their effects on tau and tubulin dynamics.
Chen JH, Tu HJ, Lin TE, Peng ZX, Wu YW, Yen SC, Sung TY, Hsieh JH, Lee HY, Pan SL, HuangFu WC, Hsu KC. Chen JH, et al. Among authors: yen sc. Biomed Pharmacother. 2024 Nov 25;181:117688. doi: 10.1016/j.biopha.2024.117688. Online ahead of print. Biomed Pharmacother. 2024. PMID: 39591664 Free article.
Discovering a novel dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) inhibitor and its impact on tau phosphorylation and amyloid-β formation.
Tu HJ, Chao MW, Lee CC, Peng CS, Wu YW, Lin TE, Chang YW, Yen SC, Hsu KC, Pan SL, HuangFu WC. Tu HJ, et al. Among authors: yen sc. J Enzyme Inhib Med Chem. 2024 Dec;39(1):2418470. doi: 10.1080/14756366.2024.2418470. Epub 2024 Nov 4. J Enzyme Inhib Med Chem. 2024. PMID: 39494990 Free PMC article.
Identification, biological evaluation, and crystallographic analysis of coumestrol as a novel dual-specificity tyrosine-phosphorylation-regulated kinase 1A inhibitor.
Peng CH, Hwang TL, Hung SC, Tu HJ, Tseng YT, Lin TE, Lee CC, Tseng YC, Ko CY, Yen SC, Hsu KC, Pan SL, HuangFu WC. Peng CH, et al. Among authors: yen sc. Int J Biol Macromol. 2024 Dec;282(Pt 4):136860. doi: 10.1016/j.ijbiomac.2024.136860. Epub 2024 Oct 29. Int J Biol Macromol. 2024. PMID: 39481728 Free article.
1,558 results