Lewis PA - Search Results

1

Genetic, structural, and molecular insights into the function of ras of complex proteins domains.

Civiero L, Dihanich S, Lewis PA, Greggio E. Civiero L, et al. Among authors: lewis pa. Chem Biol. 2014 Jul 17;21(7):809-18. doi: 10.1016/j.chembiol.2014.05.010. Epub 2014 Jun 26. Chem Biol. 2014. PMID: 24981771 Free PMC article. Review.

2

Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1.

Greggio E, Lewis PA, van der Brug MP, Ahmad R, Kaganovich A, Ding J, Beilina A, Baker AK, Cookson MR. Greggio E, et al. Among authors: lewis pa. J Neurochem. 2007 Jul;102(1):93-102. doi: 10.1111/j.1471-4159.2007.04523.x. Epub 2007 Mar 29. J Neurochem. 2007. PMID: 17394548 Free article.

3

The R1441C mutation of LRRK2 disrupts GTP hydrolysis.

Lewis PA, Greggio E, Beilina A, Jain S, Baker A, Cookson MR. Lewis PA, et al. Biochem Biophys Res Commun. 2007 Jun 8;357(3):668-71. doi: 10.1016/j.bbrc.2007.04.006. Epub 2007 Apr 10. Biochem Biophys Res Commun. 2007. PMID: 17442267 Free PMC article.

4

Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase.

Deng J, Lewis PA, Greggio E, Sluch E, Beilina A, Cookson MR. Deng J, et al. Among authors: lewis pa. Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1499-504. doi: 10.1073/pnas.0709098105. Epub 2008 Jan 29. Proc Natl Acad Sci U S A. 2008. PMID: 18230735 Free PMC article.

5

The function of ROCO proteins in health and disease.

Lewis PA. Lewis PA. Biol Cell. 2009 Mar;101(3):183-91. doi: 10.1042/BC20080053. Biol Cell. 2009. PMID: 19152505 Review.

6

The R1441C mutation alters the folding properties of the ROC domain of LRRK2.

Li Y, Dunn L, Greggio E, Krumm B, Jackson GS, Cookson MR, Lewis PA, Deng J. Li Y, et al. Among authors: lewis pa. Biochim Biophys Acta. 2009 Dec;1792(12):1194-7. doi: 10.1016/j.bbadis.2009.09.010. Epub 2009 Sep 23. Biochim Biophys Acta. 2009. PMID: 19781641 Free PMC article.

7

LRRK2 and human disease: a complicated question or a question of complexes?

Lewis PA, Manzoni C. Lewis PA, et al. Sci Signal. 2012 Jan 17;5(207):pe2. doi: 10.1126/scisignal.2002680. Sci Signal. 2012. PMID: 22253261

8

GTP binding and intramolecular regulation by the ROC domain of Death Associated Protein Kinase 1.

Jebelli JD, Dihanich S, Civiero L, Manzoni C, Greggio E, Lewis PA. Jebelli JD, et al. Among authors: lewis pa. Sci Rep. 2012;2:695. doi: 10.1038/srep00695. Epub 2012 Sep 26. Sci Rep. 2012. PMID: 23019516 Free PMC article.

9

Divergent α-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases.

Mamais A, Raja M, Manzoni C, Dihanich S, Lees A, Moore D, Lewis PA, Bandopadhyay R. Mamais A, et al. Among authors: lewis pa. Neurobiol Dis. 2013 Oct;58:183-90. doi: 10.1016/j.nbd.2013.05.017. Epub 2013 Jun 5. Neurobiol Dis. 2013. PMID: 23747310 Free PMC article.

10

Inhibition of LRRK2 kinase activity stimulates macroautophagy.

Manzoni C, Mamais A, Dihanich S, Abeti R, Soutar MPM, Plun-Favreau H, Giunti P, Tooze SA, Bandopadhyay R, Lewis PA. Manzoni C, et al. Among authors: lewis pa. Biochim Biophys Acta. 2013 Dec;1833(12):2900-2910. doi: 10.1016/j.bbamcr.2013.07.020. Epub 2013 Aug 1. Biochim Biophys Acta. 2013. PMID: 23916833 Free PMC article.

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