Pradhan RS - Search Results

1

Studying navitoclax, a targeted anticancer drug, in healthy volunteers--ethical considerations and risk/benefit assessments and management.

Xiong H, Pradhan RS, Nada A, Krivoshik AP, Holen KD, Rhodes JW, Gordon GB, Humerickhouse R, Awni WM. Xiong H, et al. Among authors: pradhan rs. Anticancer Res. 2014 Jul;34(7):3739-46. Anticancer Res. 2014. PMID: 24982396 Clinical Trial.

2

Effect of rifampin on the pharmacokinetics, safety and tolerability of navitoclax (ABT-263), a dual inhibitor of Bcl-2 and Bcl-XL , in patients with cancer.

Yang J, Pradhan RS, Rosen LS, Graham AM, Holen KD, Xiong H. Yang J, et al. Among authors: pradhan rs. J Clin Pharm Ther. 2014 Dec;39(6):680-4. doi: 10.1111/jcpt.12193. Epub 2014 Jul 22. J Clin Pharm Ther. 2014. PMID: 25047139 Clinical Trial.

3

Effect of co-administration of ketoconazole, a strong CYP3A inhibitor, on the pharmacokinetics, safety and tolerability of navitoclax, a first-in-class oral Bcl-2 family inhibitor, in cancer patients.

Salem AH, Yang J, Graham A, Patnaik A, Holen K, Pradhan R, Xiong H. Salem AH, et al. Anticancer Res. 2014 Apr;34(4):2001-6. Anticancer Res. 2014. PMID: 24692738

4

ABT-335, the choline salt of fenofibric acid, does not have a clinically significant pharmacokinetic interaction with rosuvastatin in humans.

Zhu T, Awni WM, Hosmane B, Kelly MT, Sleep DJ, Stolzenbach JC, Wan K, Chira TO, Pradhan RS. Zhu T, et al. Among authors: pradhan rs. J Clin Pharmacol. 2009 Jan;49(1):63-71. doi: 10.1177/0091270008325671. Epub 2008 Oct 24. J Clin Pharmacol. 2009. PMID: 18952910 Clinical Trial.

5

Phase I/II study of pemetrexed with or without ABT-751 in advanced or metastatic non-small-cell lung cancer.

Rudin CM, Mauer A, Smakal M, Juergens R, Spelda S, Wertheim M, Coates A, McKeegan E, Ansell P, Zhou X, Qian J, Pradhan R, Dowell B, Krivoshik A, Gordon G. Rudin CM, et al. J Clin Oncol. 2011 Mar 10;29(8):1075-82. doi: 10.1200/JCO.2010.32.5944. Epub 2011 Feb 7. J Clin Oncol. 2011. PMID: 21300929 Free PMC article. Clinical Trial.

6

Exposure-clinical response analysis of paricalcitol in patients with chronic kidney disease (stage 5) on hemodialysis or peritoneal dialysis.

Noertersheuser PA, Pradhan RS, Klein CE, Williams LA, Palaparthy R, Garimella TS, Lichtenberger O, Awni WM. Noertersheuser PA, et al. Among authors: pradhan rs. J Clin Pharmacol. 2012 Aug;52(8):1162-73. doi: 10.1177/0091270011412966. Epub 2011 Sep 22. J Clin Pharmacol. 2012. PMID: 21940716 Clinical Trial.

7

A phase I multiple-dose escalation study characterizing pharmacokinetics and safety of ABT-578 in healthy subjects.

Karyekar CS, Pradhan RS, Freeney T, Ji Q, Edeki T, Chiu W, Awni WM, Locke C, Schwartz LB, Granneman RG, O'Dea R. Karyekar CS, et al. Among authors: pradhan rs. J Clin Pharmacol. 2005 Aug;45(8):910-8. doi: 10.1177/0091270005278807. J Clin Pharmacol. 2005. PMID: 16027401 Clinical Trial.

8

Effect of omeprazole on the pharmacokinetics of paricalcitol in healthy subjects.

Palaparthy R, Pradhan RS, Chan J, Rieser M, Chira T, Galitz L, Awni W, Williams LA. Palaparthy R, et al. Among authors: pradhan rs. Biopharm Drug Dispos. 2007 Mar;28(2):65-71. doi: 10.1002/bdd.532. Biopharm Drug Dispos. 2007. PMID: 17173278 Clinical Trial.

9

Phase I and biomarker study of ABT-869, a multiple receptor tyrosine kinase inhibitor, in patients with refractory solid malignancies.

Wong CI, Koh TS, Soo R, Hartono S, Thng CH, McKeegan E, Yong WP, Chen CS, Lee SC, Wong J, Lim R, Sukri N, Lim SE, Ong AB, Steinberg J, Gupta N, Pradhan R, Humerickhouse R, Goh BC. Wong CI, et al. J Clin Oncol. 2009 Oct 1;27(28):4718-26. doi: 10.1200/JCO.2008.21.7125. Epub 2009 Aug 31. J Clin Oncol. 2009. PMID: 19720910 Clinical Trial.

10

Exposure-response (safety) analysis to identify linifanib dose for a Phase III study in patients with hepatocellular carcinoma.

Chiu YL, Carlson DM, Pradhan RS, Ricker JL. Chiu YL, et al. Among authors: pradhan rs. Clin Ther. 2013 Nov;35(11):1770-7. doi: 10.1016/j.clinthera.2013.09.002. Epub 2013 Oct 2. Clin Ther. 2013. PMID: 24094464 Clinical Trial.

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