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Page 1
OTX008, a selective small-molecule inhibitor of galectin-1, downregulates cancer cell proliferation, invasion and tumour angiogenesis.
Astorgues-Xerri L, Riveiro ME, Tijeras-Raballand A, Serova M, Rabinovich GA, Bieche I, Vidaud M, de Gramont A, Martinet M, Cvitkovic E, Faivre S, Raymond E. Astorgues-Xerri L, et al. Among authors: rabinovich ga. Eur J Cancer. 2014 Sep;50(14):2463-77. doi: 10.1016/j.ejca.2014.06.015. Epub 2014 Jul 16. Eur J Cancer. 2014. PMID: 25042151
Galectin-1 as a potential cancer target.
Rabinovich GA. Rabinovich GA. Br J Cancer. 2005 Apr 11;92(7):1188-92. doi: 10.1038/sj.bjc.6602493. Br J Cancer. 2005. PMID: 15785741 Free PMC article. Review.
Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi's sarcoma.
Croci DO, Salatino M, Rubinstein N, Cerliani JP, Cavallin LE, Leung HJ, Ouyang J, Ilarregui JM, Toscano MA, Domaica CI, Croci MC, Shipp MA, Mesri EA, Albini A, Rabinovich GA. Croci DO, et al. Among authors: rabinovich ga. J Exp Med. 2012 Oct 22;209(11):1985-2000. doi: 10.1084/jem.20111665. Epub 2012 Oct 1. J Exp Med. 2012. PMID: 23027923 Free PMC article.
A unique galectin signature in human prostate cancer progression suggests galectin-1 as a key target for treatment of advanced disease.
Laderach DJ, Gentilini LD, Giribaldi L, Delgado VC, Nugnes L, Croci DO, Al Nakouzi N, Sacca P, Casas G, Mazza O, Shipp MA, Vazquez E, Chauchereau A, Kutok JL, Rodig SJ, Elola MT, Compagno D, Rabinovich GA. Laderach DJ, et al. Among authors: rabinovich ga. Cancer Res. 2013 Jan 1;73(1):86-96. doi: 10.1158/0008-5472.CAN-12-1260. Epub 2012 Oct 29. Cancer Res. 2013. PMID: 23108139
Targeting galectin-1 overcomes breast cancer-associated immunosuppression and prevents metastatic disease.
Dalotto-Moreno T, Croci DO, Cerliani JP, Martinez-Allo VC, Dergan-Dylon S, Méndez-Huergo SP, Stupirski JC, Mazal D, Osinaga E, Toscano MA, Sundblad V, Rabinovich GA, Salatino M. Dalotto-Moreno T, et al. Among authors: rabinovich ga. Cancer Res. 2013 Feb 1;73(3):1107-17. doi: 10.1158/0008-5472.CAN-12-2418. Epub 2012 Nov 29. Cancer Res. 2013. PMID: 23204230
Glycosylation-dependent lectin-receptor interactions preserve angiogenesis in anti-VEGF refractory tumors.
Croci DO, Cerliani JP, Dalotto-Moreno T, Méndez-Huergo SP, Mascanfroni ID, Dergan-Dylon S, Toscano MA, Caramelo JJ, García-Vallejo JJ, Ouyang J, Mesri EA, Junttila MR, Bais C, Shipp MA, Salatino M, Rabinovich GA. Croci DO, et al. Among authors: rabinovich ga. Cell. 2014 Feb 13;156(4):744-58. doi: 10.1016/j.cell.2014.01.043. Cell. 2014. PMID: 24529377 Free article.
Galectin-8: a matricellular lectin with key roles in angiogenesis.
Troncoso MF, Ferragut F, Bacigalupo ML, Cárdenas Delgado VM, Nugnes LG, Gentilini L, Laderach D, Wolfenstein-Todel C, Compagno D, Rabinovich GA, Elola MT. Troncoso MF, et al. Among authors: rabinovich ga. Glycobiology. 2014 Oct;24(10):907-14. doi: 10.1093/glycob/cwu054. Epub 2014 Jun 16. Glycobiology. 2014. PMID: 24939370 Review.
332 results