van Boxtel R - Search Results

1

Genome sequencing of normal cells reveals developmental lineages and mutational processes.

Behjati S, Huch M, van Boxtel R, Karthaus W, Wedge DC, Tamuri AU, Martincorena I, Petljak M, Alexandrov LB, Gundem G, Tarpey PS, Roerink S, Blokker J, Maddison M, Mudie L, Robinson B, Nik-Zainal S, Campbell P, Goldman N, van de Wetering M, Cuppen E, Clevers H, Stratton MR. Behjati S, et al. Among authors: van boxtel r, van de wetering m. Nature. 2014 Sep 18;513(7518):422-425. doi: 10.1038/nature13448. Epub 2014 Jun 29. Nature. 2014. PMID: 25043003 Free PMC article.

2

Transient Differentiation-State Plasticity Occurs during Acute Lymphoblastic Leukemia Initiation.

Poort VM, Hagelaar R, van Roosmalen MJ, Trabut L, Buijs-Gladdines JGCAM, van Wijk B, Meijerink J, van Boxtel R. Poort VM, et al. Among authors: van boxtel r. Cancer Res. 2024 Aug 15;84(16):2720-2733. doi: 10.1158/0008-5472.CAN-24-1090. Cancer Res. 2024. PMID: 38885294 Free PMC article.

3

Lack of DNA mismatch repair protein MSH6 in the rat results in hereditary non-polyposis colorectal cancer-like tumorigenesis.

van Boxtel R, Toonen PW, van Roekel HS, Verheul M, Smits BM, Korving J, de Bruin A, Cuppen E. van Boxtel R, et al. Among authors: van roekel hs. Carcinogenesis. 2008 Jun;29(6):1290-7. doi: 10.1093/carcin/bgn094. Epub 2008 Apr 15. Carcinogenesis. 2008. PMID: 18417481

4

Improved generation of rat gene knockouts by target-selected mutagenesis in mismatch repair-deficient animals.

van Boxtel R, Toonen PW, Verheul M, van Roekel HS, Nijman IJ, Guryev V, Cuppen E. van Boxtel R, et al. Among authors: van roekel hs. BMC Genomics. 2008 Oct 7;9:460. doi: 10.1186/1471-2164-9-460. BMC Genomics. 2008. PMID: 18840264 Free PMC article.

5

ENU mutagenesis to generate genetically modified rat models.

van Boxtel R, Gould MN, Cuppen E, Smits BM. van Boxtel R, et al. Methods Mol Biol. 2010;597:151-67. doi: 10.1007/978-1-60327-389-3_11. Methods Mol Biol. 2010. PMID: 20013232

6

Systematic generation of in vivo G protein-coupled receptor mutants in the rat.

van Boxtel R, Vroling B, Toonen P, Nijman IJ, van Roekel H, Verheul M, Baakman C, Guryev V, Vriend G, Cuppen E. van Boxtel R, et al. Among authors: van roekel h. Pharmacogenomics J. 2011 Oct;11(5):326-36. doi: 10.1038/tpj.2010.44. Epub 2010 Jun 8. Pharmacogenomics J. 2011. PMID: 20531371 Free PMC article.

7

Rat traps: filling the toolbox for manipulating the rat genome.

van Boxtel R, Cuppen E. van Boxtel R, et al. Genome Biol. 2010;11(9):217. doi: 10.1186/gb-2010-11-9-217. Epub 2010 Sep 29. Genome Biol. 2010. PMID: 20887642 Free PMC article. Review.

8

Mutation discovery by targeted genomic enrichment of multiplexed barcoded samples.

Nijman IJ, Mokry M, van Boxtel R, Toonen P, de Bruijn E, Cuppen E. Nijman IJ, et al. Among authors: van boxtel r. Nat Methods. 2010 Nov;7(11):913-5. doi: 10.1038/nmeth.1516. Epub 2010 Oct 17. Nat Methods. 2010. PMID: 20953175

9

Generation of genetically modified rodents using random ENU mutagenesis.

van Boxtel R, Cuppen E. van Boxtel R, et al. Methods Mol Biol. 2011;693:295-308. doi: 10.1007/978-1-60761-974-1_18. Methods Mol Biol. 2011. PMID: 21080288

10

Melanocortin receptor 4 deficiency affects body weight regulation, grooming behavior, and substrate preference in the rat.

Mul JD, van Boxtel R, Bergen DJ, Brans MA, Brakkee JH, Toonen PW, Garner KM, Adan RA, Cuppen E. Mul JD, et al. Among authors: van boxtel r. Obesity (Silver Spring). 2012 Mar;20(3):612-21. doi: 10.1038/oby.2011.81. Epub 2011 Apr 28. Obesity (Silver Spring). 2012. PMID: 21527895 Free PMC article.

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