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KT-253, A Novel MDM2 Degrader and p53 Stabilizer, Has Superior Potency and Efficacy Than MDM2 Small Molecule Inhibitors.
Chutake YK, Mayo MF, Dumont N, Filiatrault J, Breitkopf SB, Cho P, Chen D, Dixit VS, Proctor WR, Kuhn EW, Bollinger Martinez S, McDonald AA, Qi J, Hu KN, Karnik R, Growney JD, Sharma K, Schalm SS, Gollerkeri AM, Mainolfi N, Williams JA, Weiss MM. Chutake YK, et al. Among authors: williams ja. Mol Cancer Ther. 2024 Dec 9. doi: 10.1158/1535-7163.MCT-24-0306. Online ahead of print. Mol Cancer Ther. 2024. PMID: 39648478
Isoprene nitrates drive new particle formation in Amazon's upper troposphere.
Curtius J, Heinritzi M, Beck LJ, Pöhlker ML, Tripathi N, Krumm BE, Holzbeck P, Nussbaumer CM, Hernández Pardo L, Klimach T, Barmpounis K, Andersen ST, Bardakov R, Bohn B, Cecchini MA, Chaboureau JP, Dauhut T, Dienhart D, Dörich R, Edtbauer A, Giez A, Hartmann A, Holanda BA, Joppe P, Kaiser K, Keber T, Klebach H, Krüger OO, Kürten A, Mallaun C, Marno D, Martinez M, Monteiro C, Nelson C, Ort L, Raj SS, Richter S, Ringsdorf A, Rocha F, Simon M, Sreekumar S, Tsokankunku A, Unfer GR, Valenti ID, Wang N, Zahn A, Zauner-Wieczorek M, Albrecht RI, Andreae MO, Artaxo P, Crowley JN, Fischer H, Harder H, Herdies DL, Machado LAT, Pöhlker C, Pöschl U, Possner A, Pozzer A, Schneider J, Williams J, Lelieveld J. Curtius J, et al. Among authors: williams j. Nature. 2024 Dec;636(8041):124-130. doi: 10.1038/s41586-024-08192-4. Epub 2024 Dec 4. Nature. 2024. PMID: 39633195 Free PMC article.
X-chromosome-wide association study for Alzheimer's disease.
Le Borgne J, Gomez L, Heikkinen S, Amin N, Ahmad S, Choi SH, Bis J, Grenier-Boley B, Rodriguez OG, Kleineidam L, Young J, Tripathi KP, Wang L, Varma A, Campos-Martin R, van der Lee S, Damotte V, de Rojas I, Palmal S; EADB, GR@ACE, DEGESCO, EADI, GERAD, DemGene, FinnGen, ADGC, CHARGE; Lipton R, Reiman E, McKee A, De Jager P, Bush W, Small S, Levey A, Saykin A, Foroud T, Albert M, Hyman B, Petersen R, Younkin S, Sano M, Wisniewski T, Vassar R, Schneider J, Henderson V, Roberson E, DeCarli C, LaFerla F, Brewer J, Swerdlow R, Van Eldik L, Hamilton-Nelson K, Paulson H, Naj A, Lopez O, Chui H, Crane P, Grabowski T, Kukull W, Asthana S, Craft S, Strittmatter S, Cruchaga C, Leverenz J, Goate A, Kamboh MI, George-Hyslop PS, Valladares O, Kuzma A, Cantwell L, Riemenschneider M, Morris J, Slifer S, Dalmasso C, Castillo A, Küçükali F, Peters O, Schneider A, Dichgans M, Rujescu D, Scherbaum N, Deckert J, Riedel-Heller S, Hausner L, Molina-Porcel L, Düzel E, Grimmer T, Wiltfang J, Heilmann-Heimbach S, Moebus S, Tegos T, Scarmeas N, Dols-Icardo O, Moreno F, Pérez-Tur J, Bullido MJ, Pastor P, Sánchez-Valle R, Álvarez V, Boada M, García-González P, Puerta R, Mir P, Real LM, Piñol-Ripoll G, García-… See abstract for full author list ➔ Le Borgne J, et al. Among authors: williams j. Mol Psychiatry. 2024 Dec 4. doi: 10.1038/s41380-024-02838-5. Online ahead of print. Mol Psychiatry. 2024. PMID: 39633006
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