Whitesell L - Search Results

1

The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy.

Scherz-Shouval R, Santagata S, Mendillo ML, Sholl LM, Ben-Aharon I, Beck AH, Dias-Santagata D, Koeva M, Stemmer SM, Whitesell L, Lindquist S. Scherz-Shouval R, et al. Among authors: whitesell l. Cell. 2014 Jul 31;158(3):564-78. doi: 10.1016/j.cell.2014.05.045. Cell. 2014. PMID: 25083868 Free PMC article.

2

Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis.

Dai C, Whitesell L, Rogers AB, Lindquist S. Dai C, et al. Among authors: whitesell l. Cell. 2007 Sep 21;130(6):1005-18. doi: 10.1016/j.cell.2007.07.020. Cell. 2007. PMID: 17889646 Free PMC article.

3

Inhibiting the transcription factor HSF1 as an anticancer strategy.

Whitesell L, Lindquist S. Whitesell L, et al. Expert Opin Ther Targets. 2009 Apr;13(4):469-78. doi: 10.1517/14728220902832697. Expert Opin Ther Targets. 2009. PMID: 19335068 Review.

4

HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers.

Mendillo ML, Santagata S, Koeva M, Bell GW, Hu R, Tamimi RM, Fraenkel E, Ince TA, Whitesell L, Lindquist S. Mendillo ML, et al. Among authors: whitesell l. Cell. 2012 Aug 3;150(3):549-62. doi: 10.1016/j.cell.2012.06.031. Cell. 2012. PMID: 22863008 Free PMC article.

5

Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state.

Santagata S, Mendillo ML, Tang YC, Subramanian A, Perley CC, Roche SP, Wong B, Narayan R, Kwon H, Koeva M, Amon A, Golub TR, Porco JA Jr, Whitesell L, Lindquist S. Santagata S, et al. Among authors: whitesell l. Science. 2013 Jul 19;341(6143):1238303. doi: 10.1126/science.1238303. Science. 2013. PMID: 23869022 Free PMC article.

6

HSF1 phase transition mediates stress adaptation and cell fate decisions.

Gaglia G, Rashid R, Yapp C, Joshi GN, Li CG, Lindquist SL, Sarosiek KA, Whitesell L, Sorger PK, Santagata S. Gaglia G, et al. Among authors: whitesell l. Nat Cell Biol. 2020 Feb;22(2):151-158. doi: 10.1038/s41556-019-0458-3. Epub 2020 Feb 3. Nat Cell Biol. 2020. PMID: 32015439 Free PMC article.

7

HSP90 and the chaperoning of cancer.

Whitesell L, Lindquist SL. Whitesell L, et al. Nat Rev Cancer. 2005 Oct;5(10):761-72. doi: 10.1038/nrc1716. Nat Rev Cancer. 2005. PMID: 16175177 Review.

8

High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer.

Santagata S, Hu R, Lin NU, Mendillo ML, Collins LC, Hankinson SE, Schnitt SJ, Whitesell L, Tamimi RM, Lindquist S, Ince TA. Santagata S, et al. Among authors: whitesell l. Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18378-83. doi: 10.1073/pnas.1115031108. Epub 2011 Oct 31. Proc Natl Acad Sci U S A. 2011. PMID: 22042860 Free PMC article.

9

Using the heat-shock response to discover anticancer compounds that target protein homeostasis.

Santagata S, Xu YM, Wijeratne EM, Kontnik R, Rooney C, Perley CC, Kwon H, Clardy J, Kesari S, Whitesell L, Lindquist S, Gunatilaka AA. Santagata S, et al. Among authors: whitesell l. ACS Chem Biol. 2012 Feb 17;7(2):340-9. doi: 10.1021/cb200353m. Epub 2011 Nov 30. ACS Chem Biol. 2012. PMID: 22050377 Free PMC article.

10

Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis.

Dai C, Santagata S, Tang Z, Shi J, Cao J, Kwon H, Bronson RT, Whitesell L, Lindquist S. Dai C, et al. Among authors: whitesell l. J Clin Invest. 2012 Oct;122(10):3742-54. doi: 10.1172/JCI62727. Epub 2012 Sep 4. J Clin Invest. 2012. PMID: 22945628 Free PMC article.

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