Lane JR - Search Results

1

A new mechanism of allostery in a G protein-coupled receptor dimer.

Lane JR, Donthamsetti P, Shonberg J, Draper-Joyce CJ, Dentry S, Michino M, Shi L, López L, Scammells PJ, Capuano B, Sexton PM, Javitch JA, Christopoulos A. Lane JR, et al. Nat Chem Biol. 2014 Sep;10(9):745-52. doi: 10.1038/nchembio.1593. Epub 2014 Aug 10. Nat Chem Biol. 2014. PMID: 25108820 Free PMC article.

2

A Monod-Wyman-Changeux mechanism can explain G protein-coupled receptor (GPCR) allosteric modulation.

Canals M, Lane JR, Wen A, Scammells PJ, Sexton PM, Christopoulos A. Canals M, et al. Among authors: lane jr. J Biol Chem. 2012 Jan 2;287(1):650-659. doi: 10.1074/jbc.M111.314278. Epub 2011 Nov 15. J Biol Chem. 2012. PMID: 22086918 Free PMC article.

3

Homobivalent ligands of the atypical antipsychotic clozapine: design, synthesis, and pharmacological evaluation.

McRobb FM, Crosby IT, Yuriev E, Lane JR, Capuano B. McRobb FM, et al. Among authors: lane jr. J Med Chem. 2012 Feb 23;55(4):1622-34. doi: 10.1021/jm201420s. Epub 2012 Feb 2. J Med Chem. 2012. PMID: 22243698

4

Bridging the gap: bitopic ligands of G-protein-coupled receptors.

Lane JR, Sexton PM, Christopoulos A. Lane JR, et al. Trends Pharmacol Sci. 2013 Jan;34(1):59-66. doi: 10.1016/j.tips.2012.10.003. Epub 2012 Nov 20. Trends Pharmacol Sci. 2013. PMID: 23177916 Review.

5

Allosteric modulation of a chemogenetically modified G protein-coupled receptor.

Abdul-Ridha A, Lane JR, Sexton PM, Canals M, Christopoulos A. Abdul-Ridha A, et al. Among authors: lane jr. Mol Pharmacol. 2013 Feb;83(2):521-30. doi: 10.1124/mol.112.083006. Epub 2012 Nov 29. Mol Pharmacol. 2013. PMID: 23197649

6

Regulation of G protein-coupled receptors by allosteric ligands.

Lane JR, Abdul-Ridha A, Canals M. Lane JR, et al. ACS Chem Neurosci. 2013 Apr 17;4(4):527-34. doi: 10.1021/cn400005t. Epub 2013 Feb 21. ACS Chem Neurosci. 2013. PMID: 23398684 Free PMC article. Review.

7

Reverse engineering of the selective agonist TBPB unveils both orthosteric and allosteric modes of action at the M₁ muscarinic acetylcholine receptor.

Keov P, Valant C, Devine SM, Lane JR, Scammells PJ, Sexton PM, Christopoulos A. Keov P, et al. Among authors: lane jr. Mol Pharmacol. 2013 Sep;84(3):425-37. doi: 10.1124/mol.113.087320. Epub 2013 Jun 24. Mol Pharmacol. 2013. PMID: 23798605

8

Structure-based ligand discovery targeting orthosteric and allosteric pockets of dopamine receptors.

Lane JR, Chubukov P, Liu W, Canals M, Cherezov V, Abagyan R, Stevens RC, Katritch V. Lane JR, et al. Mol Pharmacol. 2013 Dec;84(6):794-807. doi: 10.1124/mol.113.088054. Epub 2013 Sep 10. Mol Pharmacol. 2013. PMID: 24021214 Free PMC article.

9

Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs.

Dror RO, Green HF, Valant C, Borhani DW, Valcourt JR, Pan AC, Arlow DH, Canals M, Lane JR, Rahmani R, Baell JB, Sexton PM, Christopoulos A, Shaw DE. Dror RO, et al. Among authors: lane jr. Nature. 2013 Nov 14;503(7475):295-9. doi: 10.1038/nature12595. Epub 2013 Oct 13. Nature. 2013. PMID: 24121438

10

A structure-activity analysis of biased agonism at the dopamine D2 receptor.

Shonberg J, Herenbrink CK, López L, Christopoulos A, Scammells PJ, Capuano B, Lane JR. Shonberg J, et al. Among authors: lane jr. J Med Chem. 2013 Nov 27;56(22):9199-221. doi: 10.1021/jm401318w. Epub 2013 Nov 8. J Med Chem. 2013. PMID: 24138311

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