Keen DA - Search Results

1

L-Arabinose binding, isomerization, and epimerization by D-xylose isomerase: X-ray/neutron crystallographic and molecular simulation study.

Langan P, Sangha AK, Wymore T, Parks JM, Yang ZK, Hanson BL, Fisher Z, Mason SA, Blakeley MP, Forsyth VT, Glusker JP, Carrell HL, Smith JC, Keen DA, Graham DE, Kovalevsky A. Langan P, et al. Among authors: keen da. Structure. 2014 Sep 2;22(9):1287-1300. doi: 10.1016/j.str.2014.07.002. Epub 2014 Aug 14. Structure. 2014. PMID: 25132082 Free article.

2

Metal ion roles and the movement of hydrogen during reaction catalyzed by D-xylose isomerase: a joint x-ray and neutron diffraction study.

Kovalevsky AY, Hanson L, Fisher SZ, Mustyakimov M, Mason SA, Forsyth VT, Blakeley MP, Keen DA, Wagner T, Carrell HL, Katz AK, Glusker JP, Langan P. Kovalevsky AY, et al. Among authors: keen da. Structure. 2010 Jun 9;18(6):688-99. doi: 10.1016/j.str.2010.03.011. Structure. 2010. PMID: 20541506 Free PMC article.

3

Identification of the elusive hydronium ion exchanging roles with a proton in an enzyme at lower pH values.

Kovalevsky AY, Hanson BL, Mason SA, Yoshida T, Fisher SZ, Mustyakimov M, Forsyth VT, Blakeley MP, Keen DA, Langan P. Kovalevsky AY, et al. Among authors: keen da. Angew Chem Int Ed Engl. 2011 Aug 8;50(33):7520-3. doi: 10.1002/anie.201101753. Epub 2011 May 23. Angew Chem Int Ed Engl. 2011. PMID: 21604345 No abstract available.

4

Inhibition of D-xylose isomerase by polyols: atomic details by joint X-ray/neutron crystallography.

Kovalevsky A, Hanson BL, Mason SA, Forsyth VT, Fisher Z, Mustyakimov M, Blakeley MP, Keen DA, Langan P. Kovalevsky A, et al. Among authors: keen da. Acta Crystallogr D Biol Crystallogr. 2012 Sep;68(Pt 9):1201-6. doi: 10.1107/S0907444912024808. Epub 2012 Aug 18. Acta Crystallogr D Biol Crystallogr. 2012. PMID: 22948921 Free PMC article.

5

Joint X-ray/neutron crystallographic study of HIV-1 protease with clinical inhibitor amprenavir: insights for drug design.

Weber IT, Waltman MJ, Mustyakimov M, Blakeley MP, Keen DA, Ghosh AK, Langan P, Kovalevsky AY. Weber IT, et al. Among authors: keen da. J Med Chem. 2013 Jul 11;56(13):5631-5. doi: 10.1021/jm400684f. Epub 2013 Jun 28. J Med Chem. 2013. PMID: 23772563 Free PMC article.

6

Long-Range Electrostatics-Induced Two-Proton Transfer Captured by Neutron Crystallography in an Enzyme Catalytic Site.

Gerlits O, Wymore T, Das A, Shen CH, Parks JM, Smith JC, Weiss KL, Keen DA, Blakeley MP, Louis JM, Langan P, Weber IT, Kovalevsky A. Gerlits O, et al. Among authors: keen da. Angew Chem Int Ed Engl. 2016 Apr 11;55(16):4924-7. doi: 10.1002/anie.201509989. Epub 2016 Mar 9. Angew Chem Int Ed Engl. 2016. PMID: 26958828 Free PMC article.

7

Room Temperature Neutron Crystallography of Drug Resistant HIV-1 Protease Uncovers Limitations of X-ray Structural Analysis at 100 K.

Gerlits O, Keen DA, Blakeley MP, Louis JM, Weber IT, Kovalevsky A. Gerlits O, et al. Among authors: keen da. J Med Chem. 2017 Mar 9;60(5):2018-2025. doi: 10.1021/acs.jmedchem.6b01767. Epub 2017 Feb 28. J Med Chem. 2017. PMID: 28195728 Free PMC article.

8

Direct visualization of critical hydrogen atoms in a pyridoxal 5'-phosphate enzyme.

Dajnowicz S, Johnston RC, Parks JM, Blakeley MP, Keen DA, Weiss KL, Gerlits O, Kovalevsky A, Mueser TC. Dajnowicz S, et al. Among authors: keen da. Nat Commun. 2017 Oct 16;8(1):955. doi: 10.1038/s41467-017-01060-y. Nat Commun. 2017. PMID: 29038582 Free PMC article.

9

Temperature-Induced Replacement of Phosphate Proton with Metal Ion Captured in Neutron Structures of A-DNA.

Vandavasi VG, Blakeley MP, Keen DA, Hu LR, Huang Z, Kovalevsky A. Vandavasi VG, et al. Among authors: keen da. Structure. 2018 Dec 4;26(12):1645-1650.e3. doi: 10.1016/j.str.2018.08.001. Epub 2018 Sep 20. Structure. 2018. PMID: 30244969 Free PMC article.

10

Proton transfer and drug binding details revealed in neutron diffraction studies of wild-type and drug resistant HIV-1 protease.

Kovalevsky A, Gerlits O, Beltran K, Weiss KL, Keen DA, Blakeley MP, Louis JM, Weber IT. Kovalevsky A, et al. Among authors: keen da. Methods Enzymol. 2020;634:257-279. doi: 10.1016/bs.mie.2019.12.002. Epub 2020 Jan 10. Methods Enzymol. 2020. PMID: 32093836 Free PMC article.

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