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IRF5:RelA interaction targets inflammatory genes in macrophages.
Saliba DG, Heger A, Eames HL, Oikonomopoulos S, Teixeira A, Blazek K, Androulidaki A, Wong D, Goh FG, Weiss M, Byrne A, Pasparakis M, Ragoussis J, Udalova IA. Saliba DG, et al. Among authors: blazek k. Cell Rep. 2014 Sep 11;8(5):1308-17. doi: 10.1016/j.celrep.2014.07.034. Epub 2014 Aug 21. Cell Rep. 2014. PMID: 25159141 Free PMC article.
IRF5 is required for late-phase TNF secretion by human dendritic cells.
Krausgruber T, Saliba D, Ryzhakov G, Lanfrancotti A, Blazek K, Udalova IA. Krausgruber T, et al. Among authors: blazek k. Blood. 2010 Jun 3;115(22):4421-30. doi: 10.1182/blood-2010-01-263020. Epub 2010 Mar 17. Blood. 2010. PMID: 20237317 Free article.
IRF5 is a specific marker of inflammatory macrophages in vivo.
Weiss M, Blazek K, Byrne AJ, Perocheau DP, Udalova IA. Weiss M, et al. Among authors: blazek k. Mediators Inflamm. 2013;2013:245804. doi: 10.1155/2013/245804. Epub 2013 Dec 23. Mediators Inflamm. 2013. PMID: 24453413 Free PMC article.
IRF5 controls both acute and chronic inflammation.
Weiss M, Byrne AJ, Blazek K, Saliba DG, Pease JE, Perocheau D, Feldmann M, Udalova IA. Weiss M, et al. Among authors: blazek k. Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):11001-6. doi: 10.1073/pnas.1506254112. Epub 2015 Aug 17. Proc Natl Acad Sci U S A. 2015. PMID: 26283380 Free PMC article.
Irf5 deficiency in macrophages promotes beneficial adipose tissue expansion and insulin sensitivity during obesity.
Dalmas E, Toubal A, Alzaid F, Blazek K, Eames HL, Lebozec K, Pini M, Hainault I, Montastier E, Denis RG, Ancel P, Lacombe A, Ling Y, Allatif O, Cruciani-Guglielmacci C, André S, Viguerie N, Poitou C, Stich V, Torcivia A, Foufelle F, Luquet S, Aron-Wisnewsky J, Langin D, Clément K, Udalova IA, Venteclef N. Dalmas E, et al. Among authors: blazek k. Nat Med. 2015 Jun;21(6):610-8. doi: 10.1038/nm.3829. Epub 2015 May 4. Nat Med. 2015. PMID: 25939064
148 results