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Brain metastasis is predetermined in early stages of cutaneous melanoma by CD44v6 expression through epigenetic regulation of the spliceosome.
Marzese DM, Liu M, Huynh JL, Hirose H, Donovan NC, Huynh KT, Kiyohara E, Chong K, Cheng D, Tanaka R, Wang J, Morton DL, Barkhoudarian G, Kelly DF, Hoon DS. Marzese DM, et al. Among authors: wang j. Pigment Cell Melanoma Res. 2015 Jan;28(1):82-93. doi: 10.1111/pcmr.12307. Epub 2014 Sep 30. Pigment Cell Melanoma Res. 2015. PMID: 25169209 Free PMC article.
Protein tyrosine phosphatase UBASH3B is overexpressed in triple-negative breast cancer and promotes invasion and metastasis.
Lee ST, Feng M, Wei Y, Li Z, Qiao Y, Guan P, Jiang X, Wong CH, Huynh K, Wang J, Li J, Karuturi KM, Tan EY, Hoon DS, Kang Y, Yu Q. Lee ST, et al. Among authors: wang j. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):11121-6. doi: 10.1073/pnas.1300873110. Epub 2013 Jun 19. Proc Natl Acad Sci U S A. 2013. PMID: 23784775 Free PMC article.
Epigenome-wide DNA methylation landscape of melanoma progression to brain metastasis reveals aberrations on homeobox D cluster associated with prognosis.
Marzese DM, Scolyer RA, Huynh JL, Huang SK, Hirose H, Chong KK, Kiyohara E, Wang J, Kawas NP, Donovan NC, Hata K, Wilmott JS, Murali R, Buckland ME, Shivalingam B, Thompson JF, Morton DL, Kelly DF, Hoon DS. Marzese DM, et al. Among authors: wang j. Hum Mol Genet. 2014 Jan 1;23(1):226-38. doi: 10.1093/hmg/ddt420. Epub 2013 Sep 6. Hum Mol Genet. 2014. PMID: 24014427 Free PMC article.
RASAL2 activates RAC1 to promote triple-negative breast cancer progression.
Feng M, Bao Y, Li Z, Li J, Gong M, Lam S, Wang J, Marzese DM, Donovan N, Tan EY, Hoon DS, Yu Q. Feng M, et al. Among authors: wang j. J Clin Invest. 2014 Dec;124(12):5291-304. doi: 10.1172/JCI76711. Epub 2014 Nov 10. J Clin Invest. 2014. PMID: 25384218 Free PMC article. Clinical Trial.
FOXC1 promotes melanoma by activating MST1R/PI3K/AKT.
Wang J, Li L, Liu S, Zhao Y, Wang L, Du G. Wang J, et al. Among authors: wang l. Oncotarget. 2016 Dec 20;7(51):84375-84387. doi: 10.18632/oncotarget.11224. Oncotarget. 2016. PMID: 27533251 Free PMC article.
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