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Page 1
VEGF blockade enables oncolytic cancer virotherapy in part by modulating intratumoral myeloid cells.
Currier MA, Eshun FK, Sholl A, Chernoguz A, Crawford K, Divanovic S, Boon L, Goins WF, Frischer JS, Collins MH, Leddon JL, Baird WH, Haseley A, Streby KA, Wang PY, Hendrickson BW, Brekken RA, Kaur B, Hildeman D, Cripe TP. Currier MA, et al. Among authors: streby ka. Mol Ther. 2013 May;21(5):1014-23. doi: 10.1038/mt.2013.39. Epub 2013 Mar 12. Mol Ther. 2013. PMID: 23481323 Free PMC article.
Neuroblastomas vary widely in their sensitivities to herpes simplex virotherapy unrelated to virus receptors and susceptibility.
Wang PY, Swain HM, Kunkler AL, Chen CY, Hutzen BJ, Arnold MA, Streby KA, Collins MH, Dipasquale B, Stanek JR, Conner J, van Kuppevelt TH, Glorioso JC, Grandi P, Cripe TP. Wang PY, et al. Among authors: streby ka. Gene Ther. 2016 Feb;23(2):135-43. doi: 10.1038/gt.2015.105. Epub 2015 Nov 19. Gene Ther. 2016. PMID: 26583803 Free PMC article.
Aurora A kinase inhibition enhances oncolytic herpes virotherapy through cytotoxic synergy and innate cellular immune modulation.
Currier MA, Sprague L, Rizvi TA, Nartker B, Chen CY, Wang PY, Hutzen BJ, Franczek MR, Patel AV, Chaney KE, Streby KA, Ecsedy JA, Conner J, Ratner N, Cripe TP. Currier MA, et al. Among authors: streby ka. Oncotarget. 2017 Mar 14;8(11):17412-17427. doi: 10.18632/oncotarget.14885. Oncotarget. 2017. PMID: 28147331 Free PMC article.
Intratumoral Injection of HSV1716, an Oncolytic Herpes Virus, Is Safe and Shows Evidence of Immune Response and Viral Replication in Young Cancer Patients.
Streby KA, Geller JI, Currier MA, Warren PS, Racadio JM, Towbin AJ, Vaughan MR, Triplet M, Ott-Napier K, Dishman DJ, Backus LR, Stockman B, Brunner M, Simpson K, Spavin R, Conner J, Cripe TP. Streby KA, et al. Clin Cancer Res. 2017 Jul 15;23(14):3566-3574. doi: 10.1158/1078-0432.CCR-16-2900. Epub 2017 May 11. Clin Cancer Res. 2017. PMID: 28495911 Free PMC article. Clinical Trial.
First-in-Human Intravenous Seprehvir in Young Cancer Patients: A Phase 1 Clinical Trial.
Streby KA, Currier MA, Triplet M, Ott K, Dishman DJ, Vaughan MR, Ranalli MA, Setty B, Skeens MA, Whiteside S, Yeager ND, Haworth KB, Simpson K, Conner J, Cripe TP. Streby KA, et al. Mol Ther. 2019 Nov 6;27(11):1930-1938. doi: 10.1016/j.ymthe.2019.08.020. Epub 2019 Sep 10. Mol Ther. 2019. PMID: 31570234 Free PMC article. Clinical Trial.
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