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Loss-of-function RNAi screens in breast cancer cells identify AURKB, PLK1, PIK3R1, MAPK12, PRKD2, and PTK6 as sensitizing targets of rapamycin activity.
Ou O, Huppi K, Chakka S, Gehlhaus K, Dubois W, Patel J, Chen J, Mackiewicz M, Jones TL, Pitt JJ, Martin SE, Goldsmith P, Simmons JK, Mock BA, Caplen NJ. Ou O, et al. Among authors: caplen nj. Cancer Lett. 2014 Nov 28;354(2):336-47. doi: 10.1016/j.canlet.2014.08.043. Epub 2014 Sep 1. Cancer Lett. 2014. PMID: 25193464 Free PMC article.
RNAi as a gene therapy approach.
Caplen NJ. Caplen NJ. Expert Opin Biol Ther. 2003 Jul;3(4):575-86. doi: 10.1517/14712598.3.4.575. Expert Opin Biol Ther. 2003. PMID: 12831363 Review.
Defining and assaying RNAi in mammalian cells.
Huppi K, Martin SE, Caplen NJ. Huppi K, et al. Among authors: caplen nj. Mol Cell. 2005 Jan 7;17(1):1-10. doi: 10.1016/j.molcel.2004.12.017. Mol Cell. 2005. PMID: 15629712 Free article. Review.
Asparagine synthetase as a causal, predictive biomarker for L-asparaginase activity in ovarian cancer cells.
Lorenzi PL, Reinhold WC, Rudelius M, Gunsior M, Shankavaram U, Bussey KJ, Scherf U, Eichler GS, Martin SE, Chin K, Gray JW, Kohn EC, Horak ID, Von Hoff DD, Raffeld M, Goldsmith PK, Caplen NJ, Weinstein JN. Lorenzi PL, et al. Among authors: caplen nj. Mol Cancer Ther. 2006 Nov;5(11):2613-23. doi: 10.1158/1535-7163.MCT-06-0447. Epub 2006 Nov 6. Mol Cancer Ther. 2006. PMID: 17088436
MicroRNAs and genomic instability.
Huppi K, Volfovsky N, Mackiewicz M, Runfola T, Jones TL, Martin SE, Stephens R, Caplen NJ. Huppi K, et al. Among authors: caplen nj. Semin Cancer Biol. 2007 Feb;17(1):65-73. doi: 10.1016/j.semcancer.2006.10.004. Epub 2006 Oct 26. Semin Cancer Biol. 2007. PMID: 17113784 Free PMC article. Review.
Multiplexing siRNAs to compress RNAi-based screen size in human cells.
Martin SE, Jones TL, Thomas CL, Lorenzi PL, Nguyen DA, Runfola T, Gunsior M, Weinstein JN, Goldsmith PK, Lader E, Huppi K, Caplen NJ. Martin SE, et al. Among authors: caplen nj. Nucleic Acids Res. 2007;35(8):e57. doi: 10.1093/nar/gkm141. Epub 2007 Mar 28. Nucleic Acids Res. 2007. PMID: 17392344 Free PMC article.
Applications of RNA interference in mammalian systems.
Martin SE, Caplen NJ. Martin SE, et al. Among authors: caplen nj. Annu Rev Genomics Hum Genet. 2007;8:81-108. doi: 10.1146/annurev.genom.8.080706.092424. Annu Rev Genomics Hum Genet. 2007. PMID: 17477824 Review.
86 results