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Coronavirus Nsp10, a critical co-factor for activation of multiple replicative enzymes.
Bouvet M, Lugari A, Posthuma CC, Zevenhoven JC, Bernard S, Betzi S, Imbert I, Canard B, Guillemot JC, Lécine P, Pfefferle S, Drosten C, Snijder EJ, Decroly E, Morelli X. Bouvet M, et al. Among authors: posthuma cc. J Biol Chem. 2014 Sep 12;289(37):25783-96. doi: 10.1074/jbc.M114.577353. Epub 2014 Jul 29. J Biol Chem. 2014. PMID: 25074927 Free PMC article.
Structure-function analysis of the nsp14 N7-guanine methyltransferase reveals an essential role in Betacoronavirus replication.
Ogando NS, El Kazzi P, Zevenhoven-Dobbe JC, Bontes BW, Decombe A, Posthuma CC, Thiel V, Canard B, Ferron F, Decroly E, Snijder EJ. Ogando NS, et al. Among authors: posthuma cc. Proc Natl Acad Sci U S A. 2021 Dec 7;118(49):e2108709118. doi: 10.1073/pnas.2108709118. Proc Natl Acad Sci U S A. 2021. PMID: 34845015 Free PMC article.
Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture.
de Wilde AH, Jochmans D, Posthuma CC, Zevenhoven-Dobbe JC, van Nieuwkoop S, Bestebroer TM, van den Hoogen BG, Neyts J, Snijder EJ. de Wilde AH, et al. Among authors: posthuma cc. Antimicrob Agents Chemother. 2014 Aug;58(8):4875-84. doi: 10.1128/AAC.03011-14. Epub 2014 May 19. Antimicrob Agents Chemother. 2014. PMID: 24841269 Free PMC article.
What we know but do not understand about nidovirus helicases.
Lehmann KC, Snijder EJ, Posthuma CC, Gorbalenya AE. Lehmann KC, et al. Among authors: posthuma cc. Virus Res. 2015 Apr 16;202:12-32. doi: 10.1016/j.virusres.2014.12.001. Epub 2014 Dec 8. Virus Res. 2015. PMID: 25497126 Free PMC article. Review.
Discovery of an essential nucleotidylating activity associated with a newly delineated conserved domain in the RNA polymerase-containing protein of all nidoviruses.
Lehmann KC, Gulyaeva A, Zevenhoven-Dobbe JC, Janssen GM, Ruben M, Overkleeft HS, van Veelen PA, Samborskiy DV, Kravchenko AA, Leontovich AM, Sidorov IA, Snijder EJ, Posthuma CC, Gorbalenya AE. Lehmann KC, et al. Among authors: posthuma cc. Nucleic Acids Res. 2015 Sep 30;43(17):8416-34. doi: 10.1093/nar/gkv838. Epub 2015 Aug 24. Nucleic Acids Res. 2015. PMID: 26304538 Free PMC article.
33 results