Thiele DJ - Search Results

1

Genomic heat shock element sequences drive cooperative human heat shock factor 1 DNA binding and selectivity.

Jaeger AM, Makley LN, Gestwicki JE, Thiele DJ. Jaeger AM, et al. Among authors: thiele dj. J Biol Chem. 2014 Oct 31;289(44):30459-30469. doi: 10.1074/jbc.M114.591578. Epub 2014 Sep 9. J Biol Chem. 2014. PMID: 25204655 Free PMC article.

2

Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases.

Neef DW, Jaeger AM, Thiele DJ. Neef DW, et al. Among authors: thiele dj. Nat Rev Drug Discov. 2011 Dec 1;10(12):930-44. doi: 10.1038/nrd3453. Nat Rev Drug Discov. 2011. PMID: 22129991 Free PMC article. Review.

3

Genetic selection for constitutively trimerized human HSF1 mutants identifies a role for coiled-coil motifs in DNA binding.

Neef DW, Jaeger AM, Thiele DJ. Neef DW, et al. Among authors: thiele dj. G3 (Bethesda). 2013 Aug 7;3(8):1315-24. doi: 10.1534/g3.113.006692. G3 (Bethesda). 2013. PMID: 23733891 Free PMC article.

4

A direct regulatory interaction between chaperonin TRiC and stress-responsive transcription factor HSF1.

Neef DW, Jaeger AM, Gomez-Pastor R, Willmund F, Frydman J, Thiele DJ. Neef DW, et al. Among authors: thiele dj. Cell Rep. 2014 Nov 6;9(3):955-66. doi: 10.1016/j.celrep.2014.09.056. Epub 2014 Oct 30. Cell Rep. 2014. PMID: 25437552 Free PMC article.

5

Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70.

Howe MK, Bodoor K, Carlson DA, Hughes PF, Alwarawrah Y, Loiselle DR, Jaeger AM, Darr DB, Jordan JL, Hunter LM, Molzberger ET, Gobillot TA, Thiele DJ, Brodsky JL, Spector NL, Haystead TA. Howe MK, et al. Among authors: thiele dj. Chem Biol. 2014 Dec 18;21(12):1648-59. doi: 10.1016/j.chembiol.2014.10.016. Epub 2014 Dec 11. Chem Biol. 2014. PMID: 25500222 Free PMC article.

6

Structures of HSF2 reveal mechanisms for differential regulation of human heat-shock factors.

Jaeger AM, Pemble CW 4th, Sistonen L, Thiele DJ. Jaeger AM, et al. Among authors: thiele dj. Nat Struct Mol Biol. 2016 Feb;23(2):147-54. doi: 10.1038/nsmb.3150. Epub 2016 Jan 4. Nat Struct Mol Biol. 2016. PMID: 26727490 Free PMC article.

7

Targeting therapy-resistant prostate cancer via a direct inhibitor of the human heat shock transcription factor 1.

Dong B, Jaeger AM, Hughes PF, Loiselle DR, Hauck JS, Fu Y, Haystead TA, Huang J, Thiele DJ. Dong B, et al. Among authors: thiele dj. Sci Transl Med. 2020 Dec 16;12(574):eabb5647. doi: 10.1126/scitranslmed.abb5647. Sci Transl Med. 2020. PMID: 33328331 Free PMC article.

8

Rational design and screening of peptide-based inhibitors of heat shock factor 1 (HSF1).

Ran X, Burchfiel ET, Dong B, Rettko NJ, Dunyak BM, Shao H, Thiele DJ, Gestwicki JE. Ran X, et al. Among authors: thiele dj. Bioorg Med Chem. 2018 Oct 15;26(19):5299-5306. doi: 10.1016/j.bmc.2018.04.018. Epub 2018 Apr 7. Bioorg Med Chem. 2018. PMID: 29661622 Free PMC article.

9

Inhibiting Heat Shock Factor 1 in Cancer: A Unique Therapeutic Opportunity.

Dong B, Jaeger AM, Thiele DJ. Dong B, et al. Among authors: thiele dj. Trends Pharmacol Sci. 2019 Dec;40(12):986-1005. doi: 10.1016/j.tips.2019.10.008. Epub 2019 Nov 11. Trends Pharmacol Sci. 2019. PMID: 31727393 Review.

10

Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington's disease.

Gomez-Pastor R, Burchfiel ET, Neef DW, Jaeger AM, Cabiscol E, McKinstry SU, Doss A, Aballay A, Lo DC, Akimov SS, Ross CA, Eroglu C, Thiele DJ. Gomez-Pastor R, et al. Among authors: thiele dj. Nat Commun. 2017 Feb 13;8:14405. doi: 10.1038/ncomms14405. Nat Commun. 2017. PMID: 28194040 Free PMC article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

189 results

Search Page

Filters