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TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.
Jay TR, Miller CM, Cheng PJ, Graham LC, Bemiller S, Broihier ML, Xu G, Margevicius D, Karlo JC, Sousa GL, Cotleur AC, Butovsky O, Bekris L, Staugaitis SM, Leverenz JB, Pimplikar SW, Landreth GE, Howell GR, Ransohoff RM, Lamb BT. Jay TR, et al. J Exp Med. 2015 Mar 9;212(3):287-95. doi: 10.1084/jem.20142322. Epub 2015 Mar 2. J Exp Med. 2015. PMID: 25732305 Free PMC article.
Peripheral macrophages not ADept at amyloid clearance.
Jay T, Lamb B, Landreth G. Jay T, et al. J Exp Med. 2015 Oct 19;212(11):1758. doi: 10.1084/jem.21211insight5. J Exp Med. 2015. PMID: 26482143 Free PMC article. No abstract available.
The evolving biology of microglia in Alzheimer's disease.
Malm TM, Jay TR, Landreth GE. Malm TM, et al. Among authors: jay tr. Neurotherapeutics. 2015 Jan;12(1):81-93. doi: 10.1007/s13311-014-0316-8. Neurotherapeutics. 2015. PMID: 25404051 Free PMC article. Review.
TREM2 in Neurodegenerative Diseases.
Jay TR, von Saucken VE, Landreth GE. Jay TR, et al. Mol Neurodegener. 2017 Aug 2;12(1):56. doi: 10.1186/s13024-017-0197-5. Mol Neurodegener. 2017. PMID: 28768545 Free PMC article. Review.
The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease.
Cheng-Hathaway PJ, Reed-Geaghan EG, Jay TR, Casali BT, Bemiller SM, Puntambekar SS, von Saucken VE, Williams RY, Karlo JC, Moutinho M, Xu G, Ransohoff RM, Lamb BT, Landreth GE. Cheng-Hathaway PJ, et al. Among authors: jay tr. Mol Neurodegener. 2018 Jun 1;13(1):29. doi: 10.1186/s13024-018-0262-8. Mol Neurodegener. 2018. PMID: 29859094 Free PMC article.
27 results