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Major groove orientation of the (2S)-N(6)-(2-hydroxy-3-buten-1-yl)-2'-deoxyadenosine DNA adduct induced by 1,2-epoxy-3-butene.
Kowal EA, Wickramaratne S, Kotapati S, Turo M, Tretyakova N, Stone MP. Kowal EA, et al. Among authors: tretyakova n. Chem Res Toxicol. 2014 Oct 20;27(10):1675-86. doi: 10.1021/tx500159w. Epub 2014 Sep 19. Chem Res Toxicol. 2014. PMID: 25238403 Free PMC article.
However, the etiology of BD-mediated genotoxicity at adenine remains poorly understood. EB alkylates the N(6) exocyclic nitrogen of adenine to form N(6)-(hydroxy-3-buten-1-yl)-2'-dA ((2S)-N(6)-HB-dA) adducts ( Tretyakova , N. , Lin , Y. , Sangai …
However, the etiology of BD-mediated genotoxicity at adenine remains poorly understood. EB alkylates the N(6) exocyclic nitrogen of a …
Formation of diastereomeric benzo[a]pyrene diol epoxide-guanine adducts in p53 gene-derived DNA sequences.
Matter B, Wang G, Jones R, Tretyakova N. Matter B, et al. Among authors: tretyakova n. Chem Res Toxicol. 2004 Jun;17(6):731-41. doi: 10.1021/tx049974l. Chem Res Toxicol. 2004. PMID: 15206894
Capillary HPLC-ESI(+)-MS/MS was used to establish the amounts of (-)-trans-N(2)-BPDE-dG, (+)-cis-N(2)-BPDE-dG, (-)-cis-N(2)-BPDE-dG, and (+)-trans-N(2)-BPDE-dG originating from the (15)N-labeled bases. ...The contributions of individual diastere …
Capillary HPLC-ESI(+)-MS/MS was used to establish the amounts of (-)-trans-N(2)-BPDE-dG, (+)-cis-N(2)-BPDE-dG, (-)-cis-N …
Guanine-adenine DNA cross-linking by 1,2,3,4-diepoxybutane: potential basis for biological activity.
Park S, Hodge J, Anderson C, Tretyakova N. Park S, et al. Among authors: tretyakova n. Chem Res Toxicol. 2004 Dec;17(12):1638-51. doi: 10.1021/tx0498206. Chem Res Toxicol. 2004. PMID: 15606140
We recently reported that DEB-induced DNA-DNA cross-linking leads to the formation of 1,4-bis-(guan-7-yl)-2,3-butanediol (bis-N7G-BD) adducts [Park, S., and Tretyakova, N. (2004) Structural characterization of the major DNA-DNA cross-link of 1,2,3,4-diepoxybutane. . …
We recently reported that DEB-induced DNA-DNA cross-linking leads to the formation of 1,4-bis-(guan-7-yl)-2,3-butanediol (bis-N7G-BD) adduct …
152 results