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Identification and development of biphenyl substituted iminosugars as improved dual glucosylceramide synthase/neutral glucosylceramidase inhibitors.
Ghisaidoobe AT, van den Berg RJ, Butt SS, Strijland A, Donker-Koopman WE, Scheij S, van den Nieuwendijk AM, Koomen GJ, van Loevezijn A, Leemhuis M, Wennekes T, van der Stelt M, van der Marel GA, van Boeckel CA, Aerts JM, Overkleeft HS. Ghisaidoobe AT, et al. Among authors: donker koopman we. J Med Chem. 2014 Nov 13;57(21):9096-104. doi: 10.1021/jm501181z. Epub 2014 Oct 17. J Med Chem. 2014. PMID: 25250725
Identification of potent and selective glucosylceramide synthase inhibitors from a library of N-alkylated iminosugars.
Ghisaidoobe A, Bikker P, de Bruijn AC, Godschalk FD, Rogaar E, Guijt MC, Hagens P, Halma JM, Van't Hart SM, Luitjens SB, van Rixel VH, Wijzenbroek M, Zweegers T, Donker-Koopman WE, Strijland A, Boot R, van der Marel G, Overkleeft HS, Aerts JM, van den Berg RJ. Ghisaidoobe A, et al. Among authors: donker koopman we. ACS Med Chem Lett. 2010 Dec 2;2(2):119-23. doi: 10.1021/ml100192b. eCollection 2011 Feb 10. ACS Med Chem Lett. 2010. PMID: 24900289 Free PMC article.
Synthesis and Evaluation of Hybrid Structures Composed of Two Glucosylceramide Synthase Inhibitors.
van den Berg RJ, van Rijssel ER, Ferraz MJ, Houben J, Strijland A, Donker-Koopman WE, Wennekes T, Bonger KM, Ghisaidoobe AB, Hoogendoorn S, van der Marel GA, Codée JD, Overkleeft HS, Aerts JM. van den Berg RJ, et al. Among authors: donker koopman we. ChemMedChem. 2015 Dec;10(12):2042-62. doi: 10.1002/cmdc.201500407. Epub 2015 Oct 23. ChemMedChem. 2015. PMID: 26492941
Ultrasensitive in situ visualization of active glucocerebrosidase molecules.
Witte MD, Kallemeijn WW, Aten J, Li KY, Strijland A, Donker-Koopman WE, van den Nieuwendijk AM, Bleijlevens B, Kramer G, Florea BI, Hooibrink B, Hollak CE, Ottenhoff R, Boot RG, van der Marel GA, Overkleeft HS, Aerts JM. Witte MD, et al. Nat Chem Biol. 2010 Dec;6(12):907-13. doi: 10.1038/nchembio.466. Epub 2010 Oct 31. Nat Chem Biol. 2010. PMID: 21079602 Free article.
Potent and selective activity-based probes for GH27 human retaining α-galactosidases.
Willems LI, Beenakker TJ, Murray B, Scheij S, Kallemeijn WW, Boot RG, Verhoek M, Donker-Koopman WE, Ferraz MJ, van Rijssel ER, Florea BI, Codée JD, van der Marel GA, Aerts JM, Overkleeft HS. Willems LI, et al. Among authors: donker koopman we. J Am Chem Soc. 2014 Aug 20;136(33):11622-5. doi: 10.1021/ja507040n. Epub 2014 Aug 11. J Am Chem Soc. 2014. PMID: 25105979
48 results