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Naphthoquinone derivatives exert their antitrypanosomal activity via a multi-target mechanism.
Pieretti S, Haanstra JR, Mazet M, Perozzo R, Bergamini C, Prati F, Fato R, Lenaz G, Capranico G, Brun R, Bakker BM, Michels PA, Scapozza L, Bolognesi ML, Cavalli A. Pieretti S, et al. Among authors: prati f. PLoS Negl Trop Dis. 2013;7(1):e2012. doi: 10.1371/journal.pntd.0002012. Epub 2013 Jan 17. PLoS Negl Trop Dis. 2013. PMID: 23350008 Free PMC article.
Molecular basis for covalent inhibition of glyceraldehyde-3-phosphate dehydrogenase by a 2-phenoxy-1,4-naphthoquinone small molecule.
Bruno S, Uliassi E, Zaffagnini M, Prati F, Bergamini C, Amorati R, Paredi G, Margiotta M, Conti P, Costi MP, Kaiser M, Cavalli A, Fato R, Bolognesi ML. Bruno S, et al. Among authors: prati f. Chem Biol Drug Des. 2017 Aug;90(2):225-235. doi: 10.1111/cbdd.12941. Epub 2017 Mar 6. Chem Biol Drug Des. 2017. PMID: 28079302 Free article.
447 results