Edmunds JJ - Search Results

1

Optimized protein kinase Cθ (PKCθ) inhibitors reveal only modest anti-inflammatory efficacy in a rodent model of arthritis.

George DM, Breinlinger EC, Argiriadi MA, Zhang Y, Wang J, Bansal-Pakala P, Duignan DB, Honore P, Lang Q, Mittelstadt S, Rundell L, Schwartz A, Sun J, Edmunds JJ. George DM, et al. Among authors: edmunds jj. J Med Chem. 2015 Jan 8;58(1):333-46. doi: 10.1021/jm5013006. Epub 2014 Oct 9. J Med Chem. 2015. PMID: 25254961

2

Design and synthesis of tricyclic cores for kinase inhibition.

Van Epps S, Fiamengo B, Edmunds J, Ericsson A, Frank K, Friedman M, George D, George J, Goedken E, Kotecki B, Martinez G, Merta P, Morytko M, Shekhar S, Skinner B, Stewart K, Voss J, Wallace G, Wang L, Wang L, Wishart N. Van Epps S, et al. Bioorg Med Chem Lett. 2013 Feb 1;23(3):693-8. doi: 10.1016/j.bmcl.2012.11.108. Epub 2012 Dec 5. Bioorg Med Chem Lett. 2013. PMID: 23265875

3

Optimization of highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase.

Powell NA, Hoffman JK, Ciske FL, Kohrt JT, Baxi SM, Peng YW, Zhong M, Catana C, Ohren J, Perrin LA, Edmunds JJ. Powell NA, et al. Among authors: edmunds jj. Bioorg Med Chem Lett. 2013 Feb 15;23(4):1051-5. doi: 10.1016/j.bmcl.2012.12.028. Epub 2012 Dec 20. Bioorg Med Chem Lett. 2013. PMID: 23312943

4

Discovery of selective and orally bioavailable protein kinase Cθ (PKCθ) inhibitors from a fragment hit.

George DM, Breinlinger EC, Friedman M, Zhang Y, Wang J, Argiriadi M, Bansal-Pakala P, Barth M, Duignan DB, Honore P, Lang Q, Mittelstadt S, Potin D, Rundell L, Edmunds JJ. George DM, et al. Among authors: edmunds jj. J Med Chem. 2015 Jan 8;58(1):222-36. doi: 10.1021/jm500669m. Epub 2014 Jul 7. J Med Chem. 2015. PMID: 25000588

5

Structure activity optimization of 6H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyrazines as Jak1 kinase inhibitors.

Friedman M, Frank KE, Aguirre A, Argiriadi MA, Davis H, Edmunds JJ, George DM, George JS, Goedken E, Fiamengo B, Hyland D, Li B, Murtaza A, Morytko M, Somal G, Stewart K, Tarcsa E, Van Epps S, Voss J, Wang L, Woller K, Wishart N. Friedman M, et al. Among authors: edmunds jj. Bioorg Med Chem Lett. 2015 Oct 15;25(20):4399-404. doi: 10.1016/j.bmcl.2015.09.020. Epub 2015 Sep 8. Bioorg Med Chem Lett. 2015. PMID: 26372653

6

Prodrugs for colon-restricted delivery: Design, synthesis, and in vivo evaluation of colony stimulating factor 1 receptor (CSF1R) inhibitors.

George DM, Huntley RJ, Cusack K, Duignan DB, Hoemann M, Loud J, Mario R, Melim T, Mullen K, Somal G, Wang L, Edmunds JJ. George DM, et al. Among authors: edmunds jj. PLoS One. 2018 Sep 7;13(9):e0203567. doi: 10.1371/journal.pone.0203567. eCollection 2018. PLoS One. 2018. PMID: 30192846 Free PMC article.

7

Targeting the Tyrosine Kinase 2 (TYK2) Pseudokinase Domain: Discovery of the Selective TYK2 Inhibitor ABBV-712.

Breinlinger E, Van Epps S, Friedman M, Argiriadi M, Chien E, Chhor G, Cowart M, Dunstan T, Graff C, Hardee D, Herold JM, Little A, McCarthy R, Parmentier J, Perham M, Qiu W, Schrimpf M, Vargo T, Webster MP, Wu F, Bennett D, Edmunds J. Breinlinger E, et al. J Med Chem. 2023 Oct 26;66(20):14335-14356. doi: 10.1021/acs.jmedchem.3c01373. Epub 2023 Oct 12. J Med Chem. 2023. PMID: 37823891

8

Potent and selective bicyclic lactam inhibitors of thrombin. Part 4: transition state inhibitors.

Bachand B, Tarazi M, St-Denis Y, Edmunds JJ, Winocour PD, Leblond L, Siddiqui MA. Bachand B, et al. Among authors: edmunds jj. Bioorg Med Chem Lett. 2001 Feb 12;11(3):287-90. doi: 10.1016/s0960-894x(00)00636-3. Bioorg Med Chem Lett. 2001. PMID: 11212093

9

Design, synthesis, and biological activity of potent and selective inhibitors of blood coagulation factor Xa.

Willardsen JA, Dudley DA, Cody WL, Chi L, McClanahan TB, Mertz TE, Potoczak RE, Narasimhan LS, Holland DR, Rapundalo ST, Edmunds JJ. Willardsen JA, et al. Among authors: edmunds jj. J Med Chem. 2004 Jul 29;47(16):4089-99. doi: 10.1021/jm0497491. J Med Chem. 2004. PMID: 15267248

10

Ketopiperazine-based renin inhibitors: optimization of the "C" ring.

Holsworth DD, Cai C, Cheng XM, Cody WL, Downing DM, Erasga N, Lee C, Powell NA, Edmunds JJ, Stier M, Jalaie M, Zhang E, McConnell P, Ryan MJ, Bryant J, Li T, Kasani A, Hall E, Subedi R, Rahim M, Maiti S. Holsworth DD, et al. Among authors: edmunds jj. Bioorg Med Chem Lett. 2006 May 1;16(9):2500-4. doi: 10.1016/j.bmcl.2006.01.084. Epub 2006 Feb 15. Bioorg Med Chem Lett. 2006. PMID: 16480874

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