Zhou J - Search Results

1

Evolutions in fragment-based drug design: the deconstruction-reconstruction approach.

Chen H, Zhou X, Wang A, Zheng Y, Gao Y, Zhou J. Chen H, et al. Among authors: zhou x, zhou j. Drug Discov Today. 2015 Jan;20(1):105-13. doi: 10.1016/j.drudis.2014.09.015. Epub 2014 Sep 27. Drug Discov Today. 2015. PMID: 25263697 Free PMC article. Review.

2

5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP.

Chen H, Tsalkova T, Mei FC, Hu Y, Cheng X, Zhou J. Chen H, et al. Among authors: zhou j. Bioorg Med Chem Lett. 2012 Jun 15;22(12):4038-43. doi: 10.1016/j.bmcl.2012.04.082. Epub 2012 Apr 26. Bioorg Med Chem Lett. 2012. PMID: 22607683 Free PMC article.

3

A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion.

Almahariq M, Tsalkova T, Mei FC, Chen H, Zhou J, Sastry SK, Schwede F, Cheng X. Almahariq M, et al. Among authors: zhou j. Mol Pharmacol. 2013 Jan;83(1):122-8. doi: 10.1124/mol.112.080689. Epub 2012 Oct 11. Mol Pharmacol. 2013. PMID: 23066090 Free PMC article.

4

A combined bioinformatics and chemoinformatics approach for developing asymmetric bivalent AMPA receptor positive allosteric modulators as neuroprotective agents.

Chen H, Wang CZ, Ding C, Wild C, Copits B, Swanson GT, Johnson KM, Zhou J. Chen H, et al. Among authors: zhou j. ChemMedChem. 2013 Feb;8(2):226-30. doi: 10.1002/cmdc.201200554. Epub 2012 Dec 20. ChemMedChem. 2013. PMID: 23281122 Free PMC article.

5

Identification and characterization of small molecules as potent and specific EPAC2 antagonists.

Chen H, Tsalkova T, Chepurny OG, Mei FC, Holz GG, Cheng X, Zhou J. Chen H, et al. Among authors: zhou j. J Med Chem. 2013 Feb 14;56(3):952-62. doi: 10.1021/jm3014162. Epub 2013 Jan 15. J Med Chem. 2013. PMID: 23286832 Free PMC article.

6

Fragment-based drug design and identification of HJC0123, a novel orally bioavailable STAT3 inhibitor for cancer therapy.

Chen H, Yang Z, Ding C, Chu L, Zhang Y, Terry K, Liu H, Shen Q, Zhou J. Chen H, et al. Among authors: zhou j. Eur J Med Chem. 2013 Apr;62:498-507. doi: 10.1016/j.ejmech.2013.01.023. Epub 2013 Jan 26. Eur J Med Chem. 2013. PMID: 23416191 Free PMC article.

7

Efficient Synthesis of ESI-09, A Novel Non-cyclic Nucleotide EPAC Antagonist.

Chen H, Ding C, Wild C, Liu H, Wang T, White MA, Cheng X, Zhou J. Chen H, et al. Among authors: zhou j. Tetrahedron Lett. 2013 Mar 20;54(12):1546-1549. doi: 10.1016/j.tetlet.2013.01.024. Tetrahedron Lett. 2013. PMID: 23459418 Free PMC article.

8

Discovery of O-Alkylamino Tethered Niclosamide Derivatives as Potent and Orally Bioavailable Anticancer Agents.

Chen H, Yang Z, Ding C, Chu L, Zhang Y, Terry K, Liu H, Shen Q, Zhou J. Chen H, et al. Among authors: zhou j. ACS Med Chem Lett. 2013 Feb 14;4(2):180-185. doi: 10.1021/ml3003082. Epub 2013 Jan 15. ACS Med Chem Lett. 2013. PMID: 23459613 Free PMC article.

9

Novel nitrogen-enriched oridonin analogues with thiazole-fused A-ring: protecting group-free synthesis, enhanced anticancer profile, and improved aqueous solubility.

Ding C, Zhang Y, Chen H, Yang Z, Wild C, Chu L, Liu H, Shen Q, Zhou J. Ding C, et al. Among authors: zhou j. J Med Chem. 2013 Jun 27;56(12):5048-58. doi: 10.1021/jm400367n. Epub 2013 Jun 19. J Med Chem. 2013. PMID: 23746196 Free PMC article.

10

Overcoming synthetic challenges of oridonin A-ring structural diversification: regio- and stereoselective installation of azides and 1,2,3-triazoles at the C-1, C-2, or C-3 position.

Ding C, Zhang Y, Chen H, Wild C, Wang T, White MA, Shen Q, Zhou J. Ding C, et al. Among authors: zhou j. Org Lett. 2013 Jul 19;15(14):3718-21. doi: 10.1021/ol4015865. Epub 2013 Jul 8. Org Lett. 2013. PMID: 23834026 Free PMC article.

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