Ernst M - Search Results

1

Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration.

Phesse TJ, Buchert M, Stuart E, Flanagan DJ, Faux M, Afshar-Sterle S, Walker F, Zhang HH, Nowell CJ, Jorissen R, Tan CW, Hirokawa Y, Eissmann MF, Poh AR, Malaterre J, Pearson HB, Kirsch DG, Provero P, Poli V, Ramsay RG, Sieber O, Burgess AW, Huszar D, Vincan E, Ernst M. Phesse TJ, et al. Among authors: ernst m. Sci Signal. 2014 Sep 30;7(345):ra92. doi: 10.1126/scisignal.2005411. Sci Signal. 2014. PMID: 25270258 Free article.

2

Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation.

Ernst M, Inglese M, Waring P, Campbell IK, Bao S, Clay FJ, Alexander WS, Wicks IP, Tarlinton DM, Novak U, Heath JK, Dunn AR. Ernst M, et al. J Exp Med. 2001 Jul 16;194(2):189-203. doi: 10.1084/jem.194.2.189. J Exp Med. 2001. PMID: 11457894 Free PMC article.

3

Acquiring signalling specificity from the cytokine receptor gp130.

Ernst M, Jenkins BJ. Ernst M, et al. Trends Genet. 2004 Jan;20(1):23-32. doi: 10.1016/j.tig.2003.11.003. Trends Genet. 2004. PMID: 14698616 Review.

4

Imbalanced gp130-dependent signaling in macrophages alters macrophage colony-stimulating factor responsiveness via regulation of c-fms expression.

Jenkins BJ, Grail D, Inglese M, Quilici C, Bozinovski S, Wong P, Ernst M. Jenkins BJ, et al. Among authors: ernst m. Mol Cell Biol. 2004 Feb;24(4):1453-63. doi: 10.1128/MCB.24.4.1453-1463.2004. Mol Cell Biol. 2004. PMID: 14749363 Free PMC article.

5

The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis.

Jenkins BJ, Roberts AW, Najdovska M, Grail D, Ernst M. Jenkins BJ, et al. Among authors: ernst m. Blood. 2005 May 1;105(9):3512-20. doi: 10.1182/blood-2004-09-3751. Epub 2005 Jan 13. Blood. 2005. PMID: 15650055 Free article.

6

Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling.

Jenkins BJ, Grail D, Nheu T, Najdovska M, Wang B, Waring P, Inglese M, McLoughlin RM, Jones SA, Topley N, Baumann H, Judd LM, Giraud AS, Boussioutas A, Zhu HJ, Ernst M. Jenkins BJ, et al. Among authors: ernst m. Nat Med. 2005 Aug;11(8):845-52. doi: 10.1038/nm1282. Epub 2005 Jul 24. Nat Med. 2005. PMID: 16041381

7

Differential regulation of gastric tumor growth by cytokines that signal exclusively through the coreceptor gp130.

Howlett M, Judd LM, Jenkins B, La Gruta NL, Grail D, Ernst M, Giraud AS. Howlett M, et al. Among authors: ernst m. Gastroenterology. 2005 Sep;129(3):1005-18. doi: 10.1053/j.gastro.2005.06.068. Gastroenterology. 2005. PMID: 16143138

8

STAT3 activation regulates growth, inflammation, and vascularization in a mouse model of gastric tumorigenesis.

Judd LM, Bredin K, Kalantzis A, Jenkins BJ, Ernst M, Giraud AS. Judd LM, et al. Among authors: ernst m. Gastroenterology. 2006 Oct;131(4):1073-85. doi: 10.1053/j.gastro.2006.07.018. Epub 2006 Jul 24. Gastroenterology. 2006. PMID: 17030178

9

Opposing roles of gp130-mediated STAT-3 and ERK-1/ 2 signaling in liver progenitor cell migration and proliferation.

Yeoh GC, Ernst M, Rose-John S, Akhurst B, Payne C, Long S, Alexander W, Croker B, Grail D, Matthews VB. Yeoh GC, et al. Among authors: ernst m. Hepatology. 2007 Feb;45(2):486-94. doi: 10.1002/hep.21535. Hepatology. 2007. PMID: 17256754

10

c-Myb is required for progenitor cell homeostasis in colonic crypts.

Malaterre J, Carpinelli M, Ernst M, Alexander W, Cooke M, Sutton S, Dworkin S, Heath JK, Frampton J, McArthur G, Clevers H, Hilton D, Mantamadiotis T, Ramsay RG. Malaterre J, et al. Among authors: ernst m. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3829-34. doi: 10.1073/pnas.0610055104. Epub 2007 Feb 26. Proc Natl Acad Sci U S A. 2007. PMID: 17360438 Free PMC article.

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