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Page 1
Novel interactions of large P3 moiety and small P4 moiety in the binding of the peptide mimetic factor VIIa inhibitor.
Kadono S, Sakamoto A, Kikuchi Y, Oh-Eda M, Yabuta N, Yoshihashi K, Kitazawa T, Suzuki T, Koga T, Hattori K, Shiraishi T, Haramura M, Kodama H, Ono Y, Esaki T, Sato H, Watanabe Y, Itoh S, Ohta M, Kozono T. Kadono S, et al. Among authors: sakamoto a. Biochem Biophys Res Commun. 2005 Jan 28;326(4):859-65. doi: 10.1016/j.bbrc.2004.11.108. Biochem Biophys Res Commun. 2005. PMID: 15607748
Structure-based design of P3 moieties in the peptide mimetic factor VIIa inhibitor.
Kadono S, Sakamoto A, Kikuchi Y, Oh-eda M, Yabuta N, Yoshihashi K, Kitazawa T, Suzuki T, Koga T, Hattori K, Shiraishi T, Haramura M, Kodama H, Ono Y, Esaki T, Sato H, Watanabe Y, Itoh S, Ohta M, Kozono T. Kadono S, et al. Among authors: sakamoto a. Biochem Biophys Res Commun. 2005 Feb 11;327(2):589-96. doi: 10.1016/j.bbrc.2004.12.042. Biochem Biophys Res Commun. 2005. PMID: 15629154
Structure of human factor VIIa/tissue factor in complex with a peptide-mimetic inhibitor: high selectivity against thrombin by introducing two charged groups in P2 and P4.
Kadono S, Sakamoto A, Kikuchi Y, Oh-Eda M, Yabuta N, Koga T, Hattori K, Shiraishi T, Haramura M, Kodama H, Ono Y, Esaki T, Sato H, Watanabe Y, Itoh S, Ohta M, Kozono T. Kadono S, et al. Among authors: sakamoto a. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Feb 1;61(Pt 2):169-73. doi: 10.1107/S1744309105000047. Epub 2005 Jan 20. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005. PMID: 16510984 Free PMC article.
Factor VIIa inhibitors: target hopping in the serine protease family using X-ray structure determination.
Shiraishi T, Kadono S, Haramura M, Kodama H, Ono Y, Iikura H, Esaki T, Koga T, Hattori K, Watanabe Y, Sakamoto A, Yoshihashi K, Kitazawa T, Esaki K, Ohta M, Sato H, Kozono T. Shiraishi T, et al. Among authors: sakamoto a. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4533-7. doi: 10.1016/j.bmcl.2008.07.044. Epub 2008 Jul 16. Bioorg Med Chem Lett. 2008. PMID: 18674905
Design and synthesis of peptidomimetic factor VIIa inhibitors.
Shiraishi T, Kadono S, Haramura M, Kodama H, Ono Y, Iikura H, Esaki T, Koga T, Hattori K, Watanabe Y, Sakamoto A, Yoshihashi K, Kitazawa T, Esaki K, Ohta M, Sato H, Kozono T. Shiraishi T, et al. Among authors: sakamoto a. Chem Pharm Bull (Tokyo). 2010 Jan;58(1):38-44. doi: 10.1248/cpb.58.38. Chem Pharm Bull (Tokyo). 2010. PMID: 20045964 Free article.
Cynomolgus monkey model of interleukin-31-induced scratching depicts blockade of human interleukin-31 receptor A by a humanized monoclonal antibody.
Oyama S, Kitamura H, Kuramochi T, Higuchi Y, Matsushita H, Suzuki T, Goto M, Adachi H, Kasutani K, Sakamoto A, Iwayanagi Y, Kaneko A, Nanami M, Fujii E, Esaki K, Takashima Y, Shimaoka S, Hattori K, Kawabe Y. Oyama S, et al. Among authors: sakamoto a. Exp Dermatol. 2018 Jan;27(1):14-21. doi: 10.1111/exd.13236. Epub 2017 Apr 10. Exp Dermatol. 2018. PMID: 27714851
Long lasting neutralization of C5 by SKY59, a novel recycling antibody, is a potential therapy for complement-mediated diseases.
Fukuzawa T, Sampei Z, Haraya K, Ruike Y, Shida-Kawazoe M, Shimizu Y, Gan SW, Irie M, Tsuboi Y, Tai H, Sakiyama T, Sakamoto A, Ishii S, Maeda A, Iwayanagi Y, Shibahara N, Shibuya M, Nakamura G, Nambu T, Hayasaka A, Mimoto F, Okura Y, Hori Y, Habu K, Wada M, Miura T, Tachibana T, Honda K, Tsunoda H, Kitazawa T, Kawabe Y, Igawa T, Hattori K, Nezu J. Fukuzawa T, et al. Among authors: sakamoto a. Sci Rep. 2017 Apr 24;7(1):1080. doi: 10.1038/s41598-017-01087-7. Sci Rep. 2017. PMID: 28439081 Free PMC article.
An anti-glypican 3/CD3 bispecific T cell-redirecting antibody for treatment of solid tumors.
Ishiguro T, Sano Y, Komatsu SI, Kamata-Sakurai M, Kaneko A, Kinoshita Y, Shiraiwa H, Azuma Y, Tsunenari T, Kayukawa Y, Sonobe Y, Ono N, Sakata K, Fujii T, Miyazaki Y, Noguchi M, Endo M, Harada A, Frings W, Fujii E, Nanba E, Narita A, Sakamoto A, Wakabayashi T, Konishi H, Segawa H, Igawa T, Tsushima T, Mutoh H, Nishito Y, Takahashi M, Stewart L, ElGabry E, Kawabe Y, Ishigai M, Chiba S, Aoki M, Hattori K, Nezu J. Ishiguro T, et al. Among authors: sakamoto a. Sci Transl Med. 2017 Oct 4;9(410):eaal4291. doi: 10.1126/scitranslmed.aal4291. Sci Transl Med. 2017. PMID: 28978751
1,907 results