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The induction of the p53 tumor suppressor protein bridges the apoptotic and autophagic signaling pathways to regulate cell death in prostate cancer cells.
Ringer L, Sirajuddin P, Tricoli L, Waye S, Choudhry MU, Parasido E, Sivakumar A, Heckler M, Naeem A, Abdelgawad I, Liu X, Feldman AS, Lee RJ, Wu CL, Yenugonda V, Kallakury B, Dritschilo A, Lynch J, Schlegel R, Rodriguez O, Pestell RG, Avantaggiati ML, Albanese C. Ringer L, et al. Among authors: schlegel r. Oncotarget. 2014 Nov 15;5(21):10678-91. doi: 10.18632/oncotarget.2528. Oncotarget. 2014. PMID: 25296977 Free PMC article.
VMY-1-103 is a novel CDK inhibitor that disrupts chromosome organization and delays metaphase progression in medulloblastoma cells.
Ringer L, Sirajuddin P, Heckler M, Ghosh A, Suprynowicz F, Yenugonda VM, Brown ML, Toretsky JA, Uren A, Lee Y, MacDonald TJ, Rodriguez O, Glazer RI, Schlegel R, Albanese C. Ringer L, et al. Among authors: schlegel r. Cancer Biol Ther. 2011 Nov 1;12(9):818-26. doi: 10.4161/cbt.12.9.17682. Epub 2011 Nov 1. Cancer Biol Ther. 2011. PMID: 21885916 Free PMC article.
Quantifying the CDK inhibitor VMY-1-103's activity and tissue levels in an in vivo tumor model by LC-MS/MS and by MRI.
Sirajuddin P, Das S, Ringer L, Rodriguez OC, Sivakumar A, Lee YC, Üren A, Fricke ST, Rood B, Ozcan A, Wang SS, Karam S, Yenugonda V, Salinas P, Petricoin E 3rd, Pishvaian M, Lisanti MP, Wang Y, Schlegel R, Moasser B, Albanese C. Sirajuddin P, et al. Among authors: schlegel r. Cell Cycle. 2012 Oct 15;11(20):3801-9. doi: 10.4161/cc.21988. Epub 2012 Sep 14. Cell Cycle. 2012. PMID: 22983062 Free PMC article.
Strigolactone analogues induce apoptosis through activation of p38 and the stress response pathway in cancer cell lines and in conditionally reprogrammed primary prostate cancer cells.
Pollock CB, McDonough S, Wang VS, Lee H, Ringer L, Li X, Prandi C, Lee RJ, Feldman AS, Koltai H, Kapulnik Y, Rodriguez OC, Schlegel R, Albanese C, Yarden RI. Pollock CB, et al. Among authors: schlegel r. Oncotarget. 2014 Mar 30;5(6):1683-98. doi: 10.18632/oncotarget.1849. Oncotarget. 2014. PMID: 24742967 Free PMC article.
Conditionally reprogrammed normal and primary tumor prostate epithelial cells: a novel patient-derived cell model for studies of human prostate cancer.
Timofeeva OA, Palechor-Ceron N, Li G, Yuan H, Krawczyk E, Zhong X, Liu G, Upadhyay G, Dakic A, Yu S, Fang S, Choudhury S, Zhang X, Ju A, Lee MS, Dan HC, Ji Y, Hou Y, Zheng YL, Albanese C, Rhim J, Schlegel R, Dritschilo A, Liu X. Timofeeva OA, et al. Among authors: schlegel r. Oncotarget. 2017 Apr 4;8(14):22741-22758. doi: 10.18632/oncotarget.13937. Oncotarget. 2017. PMID: 28009986 Free PMC article.
ROCK inhibitor and feeder cells induce the conditional reprogramming of epithelial cells.
Liu X, Ory V, Chapman S, Yuan H, Albanese C, Kallakury B, Timofeeva OA, Nealon C, Dakic A, Simic V, Haddad BR, Rhim JS, Dritschilo A, Riegel A, McBride A, Schlegel R. Liu X, et al. Among authors: schlegel r. Am J Pathol. 2012 Feb;180(2):599-607. doi: 10.1016/j.ajpath.2011.10.036. Epub 2011 Dec 18. Am J Pathol. 2012. PMID: 22189618 Free PMC article.
Use of reprogrammed cells to identify therapy for respiratory papillomatosis.
Yuan H, Myers S, Wang J, Zhou D, Woo JA, Kallakury B, Ju A, Bazylewicz M, Carter YM, Albanese C, Grant N, Shad A, Dritschilo A, Liu X, Schlegel R. Yuan H, et al. Among authors: schlegel r. N Engl J Med. 2012 Sep 27;367(13):1220-7. doi: 10.1056/NEJMoa1203055. N Engl J Med. 2012. PMID: 23013073 Free PMC article.
552 results