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A three-dimensional human neural cell culture model of Alzheimer's disease.
Choi SH, Kim YH, Hebisch M, Sliwinski C, Lee S, D'Avanzo C, Chen H, Hooli B, Asselin C, Muffat J, Klee JB, Zhang C, Wainger BJ, Peitz M, Kovacs DM, Woolf CJ, Wagner SL, Tanzi RE, Kim DY. Choi SH, et al. Among authors: woolf cj. Nature. 2014 Nov 13;515(7526):274-8. doi: 10.1038/nature13800. Epub 2014 Oct 12. Nature. 2014. PMID: 25307057 Free PMC article.
BACE1 regulates voltage-gated sodium channels and neuronal activity.
Kim DY, Carey BW, Wang H, Ingano LA, Binshtok AM, Wertz MH, Pettingell WH, He P, Lee VM, Woolf CJ, Kovacs DM. Kim DY, et al. Among authors: woolf cj. Nat Cell Biol. 2007 Jul;9(7):755-64. doi: 10.1038/ncb1602. Epub 2007 Jun 18. Nat Cell Biol. 2007. PMID: 17576410 Free PMC article.
A functionally characterized test set of human induced pluripotent stem cells.
Boulting GL, Kiskinis E, Croft GF, Amoroso MW, Oakley DH, Wainger BJ, Williams DJ, Kahler DJ, Yamaki M, Davidow L, Rodolfa CT, Dimos JT, Mikkilineni S, MacDermott AB, Woolf CJ, Henderson CE, Wichterle H, Eggan K. Boulting GL, et al. Among authors: woolf cj. Nat Biotechnol. 2011 Mar;29(3):279-86. doi: 10.1038/nbt.1783. Epub 2011 Feb 3. Nat Biotechnol. 2011. PMID: 21293464 Free PMC article.
CLP1 links tRNA metabolism to progressive motor-neuron loss.
Hanada T, Weitzer S, Mair B, Bernreuther C, Wainger BJ, Ichida J, Hanada R, Orthofer M, Cronin SJ, Komnenovic V, Minis A, Sato F, Mimata H, Yoshimura A, Tamir I, Rainer J, Kofler R, Yaron A, Eggan KC, Woolf CJ, Glatzel M, Herbst R, Martinez J, Penninger JM. Hanada T, et al. Among authors: woolf cj. Nature. 2013 Mar 28;495(7442):474-80. doi: 10.1038/nature11923. Epub 2013 Mar 10. Nature. 2013. PMID: 23474986 Free PMC article.
A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS.
Yang YM, Gupta SK, Kim KJ, Powers BE, Cerqueira A, Wainger BJ, Ngo HD, Rosowski KA, Schein PA, Ackeifi CA, Arvanites AC, Davidow LS, Woolf CJ, Rubin LL. Yang YM, et al. Among authors: woolf cj. Cell Stem Cell. 2013 Jun 6;12(6):713-26. doi: 10.1016/j.stem.2013.04.003. Epub 2013 Apr 18. Cell Stem Cell. 2013. PMID: 23602540 Free PMC article.
Bacteria activate sensory neurons that modulate pain and inflammation.
Chiu IM, Heesters BA, Ghasemlou N, Von Hehn CA, Zhao F, Tran J, Wainger B, Strominger A, Muralidharan S, Horswill AR, Bubeck Wardenburg J, Hwang SW, Carroll MC, Woolf CJ. Chiu IM, et al. Among authors: woolf cj. Nature. 2013 Sep 5;501(7465):52-7. doi: 10.1038/nature12479. Epub 2013 Aug 21. Nature. 2013. PMID: 23965627 Free PMC article.
Bupivacaine-induced cellular entry of QX-314 and its contribution to differential nerve block.
Brenneis C, Kistner K, Puopolo M, Jo S, Roberson D, Sisignano M, Segal D, Cobos EJ, Wainger BJ, Labocha S, Ferreirós N, von Hehn C, Tran J, Geisslinger G, Reeh PW, Bean BP, Woolf CJ. Brenneis C, et al. Among authors: woolf cj. Br J Pharmacol. 2014 Jan;171(2):438-51. doi: 10.1111/bph.12466. Br J Pharmacol. 2014. PMID: 24117225 Free PMC article.
Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1.
Kiskinis E, Sandoe J, Williams LA, Boulting GL, Moccia R, Wainger BJ, Han S, Peng T, Thams S, Mikkilineni S, Mellin C, Merkle FT, Davis-Dusenbery BN, Ziller M, Oakley D, Ichida J, Di Costanzo S, Atwater N, Maeder ML, Goodwin MJ, Nemesh J, Handsaker RE, Paull D, Noggle S, McCarroll SA, Joung JK, Woolf CJ, Brown RH, Eggan K. Kiskinis E, et al. Among authors: woolf cj. Cell Stem Cell. 2014 Jun 5;14(6):781-95. doi: 10.1016/j.stem.2014.03.004. Epub 2014 Apr 3. Cell Stem Cell. 2014. PMID: 24704492 Free PMC article.
456 results