Fairbrother WJ - Search Results

1

Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.

Tao ZF, Hasvold L, Wang L, Wang X, Petros AM, Park CH, Boghaert ER, Catron ND, Chen J, Colman PM, Czabotar PE, Deshayes K, Fairbrother WJ, Flygare JA, Hymowitz SG, Jin S, Judge RA, Koehler MF, Kovar PJ, Lessene G, Mitten MJ, Ndubaku CO, Nimmer P, Purkey HE, Oleksijew A, Phillips DC, Sleebs BE, Smith BJ, Smith ML, Tahir SK, Watson KG, Xiao Y, Xue J, Zhang H, Zobel K, Rosenberg SH, Tse C, Leverson JD, Elmore SW, Souers AJ. Tao ZF, et al. Among authors: fairbrother wj. ACS Med Chem Lett. 2014 Aug 26;5(10):1088-93. doi: 10.1021/ml5001867. eCollection 2014 Oct 9. ACS Med Chem Lett. 2014. PMID: 25313317 Free PMC article.

2

Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.

Jackson DY, Quan C, Artis DR, Rawson T, Blackburn B, Struble M, Fitzgerald G, Chan K, Mullins S, Burnier JP, Fairbrother WJ, Clark K, Berisini M, Chui H, Renz M, Jones S, Fong S. Jackson DY, et al. Among authors: fairbrother wj. J Med Chem. 1997 Oct 10;40(21):3359-68. doi: 10.1021/jm970175s. J Med Chem. 1997. PMID: 9341911

3

SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP).

Vucic D, Deshayes K, Ackerly H, Pisabarro MT, Kadkhodayan S, Fairbrother WJ, Dixit VM. Vucic D, et al. Among authors: fairbrother wj. J Biol Chem. 2002 Apr 5;277(14):12275-9. doi: 10.1074/jbc.M112045200. Epub 2002 Jan 18. J Biol Chem. 2002. PMID: 11801603 Free article.

4

Exploring protein-protein interactions with phage display.

Sidhu SS, Fairbrother WJ, Deshayes K. Sidhu SS, et al. Among authors: fairbrother wj. Chembiochem. 2003 Jan 3;4(1):14-25. doi: 10.1002/cbic.200390008. Chembiochem. 2003. PMID: 12512072 Review.

5

BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site.

Gordon NC, Pan B, Hymowitz SG, Yin J, Kelley RF, Cochran AG, Yan M, Dixit VM, Fairbrother WJ, Starovasnik MA. Gordon NC, et al. Among authors: fairbrother wj. Biochemistry. 2003 May 27;42(20):5977-83. doi: 10.1021/bi034017g. Biochemistry. 2003. PMID: 12755599

6

Structure and function analysis of peptide antagonists of melanoma inhibitor of apoptosis (ML-IAP).

Franklin MC, Kadkhodayan S, Ackerly H, Alexandru D, Distefano MD, Elliott LO, Flygare JA, Mausisa G, Okawa DC, Ong D, Vucic D, Deshayes K, Fairbrother WJ. Franklin MC, et al. Among authors: fairbrother wj. Biochemistry. 2003 Jul 15;42(27):8223-31. doi: 10.1021/bi034227t. Biochemistry. 2003. PMID: 12846571

7

Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP.

Vucic D, Franklin MC, Wallweber HJ, Das K, Eckelman BP, Shin H, Elliott LO, Kadkhodayan S, Deshayes K, Salvesen GS, Fairbrother WJ. Vucic D, et al. Among authors: fairbrother wj. Biochem J. 2005 Jan 1;385(Pt 1):11-20. doi: 10.1042/BJ20041108. Biochem J. 2005. PMID: 15485396 Free PMC article.

8

Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs.

Zobel K, Wang L, Varfolomeev E, Franklin MC, Elliott LO, Wallweber HJ, Okawa DC, Flygare JA, Vucic D, Fairbrother WJ, Deshayes K. Zobel K, et al. Among authors: fairbrother wj. ACS Chem Biol. 2006 Sep 19;1(8):525-33. doi: 10.1021/cb600276q. ACS Chem Biol. 2006. PMID: 17168540

9

Evaluation of assay technologies for the identification of protein-Peptide interaction antagonists.

Kadkhodayan S, Elliott LO, Mausisa G, Wallweber HA, Deshayes K, Feng B, Fairbrother WJ. Kadkhodayan S, et al. Among authors: fairbrother wj. Assay Drug Dev Technol. 2007 Aug;5(4):501-13. doi: 10.1089/adt.2007.070. Assay Drug Dev Technol. 2007. PMID: 17767418

10

IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis.

Varfolomeev E, Blankenship JW, Wayson SM, Fedorova AV, Kayagaki N, Garg P, Zobel K, Dynek JN, Elliott LO, Wallweber HJ, Flygare JA, Fairbrother WJ, Deshayes K, Dixit VM, Vucic D. Varfolomeev E, et al. Among authors: fairbrother wj. Cell. 2007 Nov 16;131(4):669-81. doi: 10.1016/j.cell.2007.10.030. Cell. 2007. PMID: 18022362 Free article.

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