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Biased multicomponent reactions to develop novel bromodomain inhibitors.
McKeown MR, Shaw DL, Fu H, Liu S, Xu X, Marineau JJ, Huang Y, Zhang X, Buckley DL, Kadam A, Zhang Z, Blacklow SC, Qi J, Zhang W, Bradner JE. McKeown MR, et al. Among authors: xu x. J Med Chem. 2014 Nov 13;57(21):9019-27. doi: 10.1021/jm501120z. Epub 2014 Oct 31. J Med Chem. 2014. PMID: 25314271 Free PMC article.
Structure-guided DOT1L probe optimization by label-free ligand displacement.
Yi JS, Federation AJ, Qi J, Dhe-Paganon S, Hadler M, Xu X, St Pierre R, Varca AC, Wu L, Marineau JJ, Smith WB, Souza A, Chory EJ, Armstrong SA, Bradner JE. Yi JS, et al. Among authors: xu x. ACS Chem Biol. 2015 Mar 20;10(3):667-74. doi: 10.1021/cb500796d. Epub 2015 Jan 15. ACS Chem Biol. 2015. PMID: 25397901 Free PMC article.
Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains.
Wang J, Erazo T, Ferguson FM, Buckley DL, Gomez N, Muñoz-Guardiola P, Diéguez-Martínez N, Deng X, Hao M, Massefski W, Fedorov O, Offei-Addo NK, Park PM, Dai L, DiBona A, Becht K, Kim ND, McKeown MR, Roberts JM, Zhang J, Sim T, Alessi DR, Bradner JE, Lizcano JM, Blacklow SC, Qi J, Xu X, Gray NS. Wang J, et al. Among authors: xu x. ACS Chem Biol. 2018 Sep 21;13(9):2438-2448. doi: 10.1021/acschembio.7b00638. Epub 2018 Aug 31. ACS Chem Biol. 2018. PMID: 30102854 Free PMC article.
Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1.
Andrawes MB, Xu X, Liu H, Ficarro SB, Marto JA, Aster JC, Blacklow SC. Andrawes MB, et al. Among authors: xu x. J Biol Chem. 2013 Aug 30;288(35):25477-25489. doi: 10.1074/jbc.M113.454850. Epub 2013 Jul 9. J Biol Chem. 2013. PMID: 23839946 Free PMC article.
STK40 Is a Pseudokinase that Binds the E3 Ubiquitin Ligase COP1.
Durzynska I, Xu X, Adelmant G, Ficarro SB, Marto JA, Sliz P, Uljon S, Blacklow SC. Durzynska I, et al. Among authors: xu x. Structure. 2017 Feb 7;25(2):287-294. doi: 10.1016/j.str.2016.12.008. Epub 2017 Jan 12. Structure. 2017. PMID: 28089446 Free PMC article.
Structural Basis for Substrate Selectivity of the E3 Ligase COP1.
Uljon S, Xu X, Durzynska I, Stein S, Adelmant G, Marto JA, Pear WS, Blacklow SC. Uljon S, et al. Among authors: xu x. Structure. 2016 May 3;24(5):687-696. doi: 10.1016/j.str.2016.03.002. Epub 2016 Mar 31. Structure. 2016. PMID: 27041596 Free PMC article.
57,418 results
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