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Functional analysis of the anti-adalimumab response using patient-derived monoclonal antibodies.
van Schouwenburg PA, Kruithof S, Votsmeier C, van Schie K, Hart MH, de Jong RN, van Buren EE, van Ham M, Aarden L, Wolbink G, Wouters D, Rispens T. van Schouwenburg PA, et al. Among authors: de jong rn. J Biol Chem. 2014 Dec 12;289(50):34482-8. doi: 10.1074/jbc.M114.615500. Epub 2014 Oct 17. J Biol Chem. 2014. PMID: 25326381 Free PMC article. Review.
Adalimumab elicits a restricted anti-idiotypic antibody response in autoimmune patients resulting in functional neutralisation.
van Schouwenburg PA, van de Stadt LA, de Jong RN, van Buren EE, Kruithof S, de Groot E, Hart M, van Ham SM, Rispens T, Aarden L, Wolbink GJ, Wouters D. van Schouwenburg PA, et al. Among authors: de jong rn, de groot e. Ann Rheum Dis. 2013 Jan;72(1):104-9. doi: 10.1136/annrheumdis-2012-201445. Epub 2012 Jul 3. Ann Rheum Dis. 2013. PMID: 22759910
Controlled Fab-arm exchange for the generation of stable bispecific IgG1.
Labrijn AF, Meesters JI, Priem P, de Jong RN, van den Bremer ET, van Kampen MD, Gerritsen AF, Schuurman J, Parren PW. Labrijn AF, et al. Among authors: de jong rn. Nat Protoc. 2014 Oct;9(10):2450-63. doi: 10.1038/nprot.2014.169. Epub 2014 Sep 25. Nat Protoc. 2014. PMID: 25255089
HER2 monoclonal antibodies that do not interfere with receptor heterodimerization-mediated signaling induce effective internalization and represent valuable components for rational antibody-drug conjugate design.
de Goeij BE, Peipp M, de Haij S, van den Brink EN, Kellner C, Riedl T, de Jong R, Vink T, Strumane K, Bleeker WK, Parren PW. de Goeij BE, et al. MAbs. 2014 Mar-Apr;6(2):392-402. doi: 10.4161/mabs.27705. Epub 2014 Jan 3. MAbs. 2014. PMID: 24492309 Free PMC article.
CD20 and CD37 antibodies synergize to activate complement by Fc-mediated clustering.
Oostindie SC, van der Horst HJ, Lindorfer MA, Cook EM, Tupitza JC, Zent CS, Burack R, VanDerMeid KR, Strumane K, Chamuleau MED, Mutis T, de Jong RN, Schuurman J, Breij ECW, Beurskens FJ, Parren PWHI, Taylor RP. Oostindie SC, et al. Among authors: de jong rn. Haematologica. 2019 Sep;104(9):1841-1852. doi: 10.3324/haematol.2018.207266. Epub 2019 Feb 21. Haematologica. 2019. PMID: 30792198 Free PMC article.
Biophysical Characterization and Stability of Modified IgG1 Antibodies with Different Hexamerization Propensities.
van Kampen MD, Kuipers-De Wilt LHAM, van Egmond ML, Reinders-Blankert P, van den Bremer ETJ, Wang G, Heck AJR, Parren PWHI, Beurskens FJ, Schuurman J, de Jong RN. van Kampen MD, et al. Among authors: de jong rn. J Pharm Sci. 2022 Jun;111(6):1587-1598. doi: 10.1016/j.xphs.2022.02.016. Epub 2022 Feb 27. J Pharm Sci. 2022. PMID: 35235843 Free article.
75 results