Dougherty TJ - Search Results

1

Target-based resistance in Pseudomonas aeruginosa and Escherichia coli to NBTI 5463, a novel bacterial type II topoisomerase inhibitor.

Nayar AS, Dougherty TJ, Reck F, Thresher J, Gao N, Shapiro AB, Ehmann DE. Nayar AS, et al. Among authors: dougherty tj. Antimicrob Agents Chemother. 2015 Jan;59(1):331-7. doi: 10.1128/AAC.04077-14. Epub 2014 Oct 27. Antimicrob Agents Chemother. 2015. PMID: 25348539 Free PMC article.

2

NBTI 5463 is a novel bacterial type II topoisomerase inhibitor with activity against gram-negative bacteria and in vivo efficacy.

Dougherty TJ, Nayar A, Newman JV, Hopkins S, Stone GG, Johnstone M, Shapiro AB, Cronin M, Reck F, Ehmann DE. Dougherty TJ, et al. Antimicrob Agents Chemother. 2014 May;58(5):2657-64. doi: 10.1128/AAC.02778-13. Epub 2014 Feb 24. Antimicrob Agents Chemother. 2014. PMID: 24566174 Free PMC article.

3

Optimization of physicochemical properties and safety profile of novel bacterial topoisomerase type II inhibitors (NBTIs) with activity against Pseudomonas aeruginosa.

Reck F, Ehmann DE, Dougherty TJ, Newman JV, Hopkins S, Stone G, Agrawal N, Ciaccio P, McNulty J, Barthlow H, O'Donnell J, Goteti K, Breen J, Comita-Prevoir J, Cornebise M, Cronin M, Eyermann CJ, Geng B, Carr GR, Pandarinathan L, Tang X, Cottone A, Zhao L, Bezdenejnih-Snyder N. Reck F, et al. Among authors: dougherty tj. Bioorg Med Chem. 2014 Oct 1;22(19):5392-409. doi: 10.1016/j.bmc.2014.07.040. Epub 2014 Aug 4. Bioorg Med Chem. 2014. PMID: 25155913

4

Novel antibacterial targets and compounds revealed by a high-throughput cell wall reporter assay.

Nayar AS, Dougherty TJ, Ferguson KE, Granger BA, McWilliams L, Stacey C, Leach LJ, Narita S, Tokuda H, Miller AA, Brown DG, McLeod SM. Nayar AS, et al. Among authors: dougherty tj. J Bacteriol. 2015 May;197(10):1726-34. doi: 10.1128/JB.02552-14. Epub 2015 Mar 2. J Bacteriol. 2015. PMID: 25733621 Free PMC article.

5

Comparison of cefepime, cefpirome, and cefaclidine binding affinities for penicillin-binding proteins in Escherichia coli K-12 and Pseudomonas aeruginosa SC8329.

Pucci MJ, Boice-Sowek J, Kessler RE, Dougherty TJ. Pucci MJ, et al. Among authors: dougherty tj. Antimicrob Agents Chemother. 1991 Nov;35(11):2312-7. doi: 10.1128/AAC.35.11.2312. Antimicrob Agents Chemother. 1991. PMID: 1804003 Free PMC article.

6

Membrane permeability changes associated with DNA gyrase inhibitors in Escherichia coli.

Dougherty TJ, Saukkonen JJ. Dougherty TJ, et al. Antimicrob Agents Chemother. 1985 Aug;28(2):200-6. doi: 10.1128/AAC.28.2.200. Antimicrob Agents Chemother. 1985. PMID: 3010837 Free PMC article.

7

Selection and genetic characterization of Streptococcus pneumoniae mutants resistant to the des-F(6) quinolone BMS-284756.

Hartman-Neumann S, DenBleyker K, Pelosi LA, Lawrence LE, Barrett JF, Dougherty TJ. Hartman-Neumann S, et al. Among authors: dougherty tj. Antimicrob Agents Chemother. 2001 Oct;45(10):2865-70. doi: 10.1128/AAC.45.10.2865-2870.2001. Antimicrob Agents Chemother. 2001. PMID: 11557482 Free PMC article.

8

Association between early inhibition of DNA synthesis and the MICs and MBCs of carboxyquinolone antimicrobial agents for wild-type and mutant [gyrA nfxB(ompF) acrA] Escherichia coli K-12.

Chow RT, Dougherty TJ, Fraimow HS, Bellin EY, Miller MH. Chow RT, et al. Among authors: dougherty tj. Antimicrob Agents Chemother. 1988 Aug;32(8):1113-8. doi: 10.1128/AAC.32.8.1113. Antimicrob Agents Chemother. 1988. PMID: 3056251 Free PMC article.

9

Transcriptional Responses of Pseudomonas aeruginosa to Inhibition of Lipoprotein Transport by a Small Molecule Inhibitor.

Lorenz C, Dougherty TJ, Lory S. Lorenz C, et al. Among authors: dougherty tj. J Bacteriol. 2020 Nov 19;202(24):e00452-20. doi: 10.1128/JB.00452-20. Print 2020 Nov 19. J Bacteriol. 2020. PMID: 32989085 Free PMC article.

10

Transcriptional Responses of Escherichia coli to a Small-Molecule Inhibitor of LolCDE, an Essential Component of the Lipoprotein Transport Pathway.

Lorenz C, Dougherty TJ, Lory S. Lorenz C, et al. Among authors: dougherty tj. J Bacteriol. 2016 Nov 4;198(23):3162-3175. doi: 10.1128/JB.00502-16. Print 2016 Dec 1. J Bacteriol. 2016. PMID: 27645386 Free PMC article.

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