Sansom OJ - Search Results

1

mTORC1-mediated translational elongation limits intestinal tumour initiation and growth.

Faller WJ, Jackson TJ, Knight JR, Ridgway RA, Jamieson T, Karim SA, Jones C, Radulescu S, Huels DJ, Myant KB, Dudek KM, Casey HA, Scopelliti A, Cordero JB, Vidal M, Pende M, Ryazanov AG, Sonenberg N, Meyuhas O, Hall MN, Bushell M, Willis AE, Sansom OJ. Faller WJ, et al. Among authors: sansom oj. Nature. 2015 Jan 22;517(7535):497-500. doi: 10.1038/nature13896. Epub 2014 Nov 5. Nature. 2015. PMID: 25383520 Free PMC article.

2

Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo.

Sansom OJ, Meniel V, Wilkins JA, Cole AM, Oien KA, Marsh V, Jamieson TJ, Guerra C, Ashton GH, Barbacid M, Clarke AR. Sansom OJ, et al. Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14122-7. doi: 10.1073/pnas.0604130103. Epub 2006 Sep 7. Proc Natl Acad Sci U S A. 2006. PMID: 16959882 Free PMC article.

3

Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis.

Dikovskaya D, Schiffmann D, Newton IP, Oakley A, Kroboth K, Sansom O, Jamieson TJ, Meniel V, Clarke A, Näthke IS. Dikovskaya D, et al. J Cell Biol. 2007 Jan 15;176(2):183-95. doi: 10.1083/jcb.200610099. J Cell Biol. 2007. PMID: 17227893 Free PMC article.

4

Myc deletion rescues Apc deficiency in the small intestine.

Sansom OJ, Meniel VS, Muncan V, Phesse TJ, Wilkins JA, Reed KR, Vass JK, Athineos D, Clevers H, Clarke AR. Sansom OJ, et al. Nature. 2007 Apr 5;446(7136):676-9. doi: 10.1038/nature05674. Epub 2007 Mar 21. Nature. 2007. PMID: 17377531

5

The pro-apoptotic K-Ras 4A proto-oncoprotein does not affect tumorigenesis in the ApcMin/+ mouse small intestine.

Patek CE, Arends MJ, Rose L, Luo F, Walker M, Devenney PS, Berry RL, Lawrence NJ, Ridgway RA, Sansom OJ, Hooper ML. Patek CE, et al. Among authors: sansom oj. BMC Gastroenterol. 2008 Jun 13;8:24. doi: 10.1186/1471-230X-8-24. BMC Gastroenterol. 2008. PMID: 18554389 Free PMC article.

6

Peptide combinatorial libraries identify TSC2 as a death-associated protein kinase (DAPK) death domain-binding protein and reveal a stimulatory role for DAPK in mTORC1 signaling.

Stevens C, Lin Y, Harrison B, Burch L, Ridgway RA, Sansom O, Hupp T. Stevens C, et al. J Biol Chem. 2009 Jan 2;284(1):334-344. doi: 10.1074/jbc.M805165200. Epub 2008 Oct 30. J Biol Chem. 2009. PMID: 18974095 Free article.

7

Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation.

Marsh V, Winton DJ, Williams GT, Dubois N, Trumpp A, Sansom OJ, Clarke AR. Marsh V, et al. Among authors: sansom oj. Nat Genet. 2008 Dec;40(12):1436-44. doi: 10.1038/ng.256. Epub 2008 Nov 16. Nat Genet. 2008. PMID: 19011632

8

B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver.

Reed KR, Athineos D, Meniel VS, Wilkins JA, Ridgway RA, Burke ZD, Muncan V, Clarke AR, Sansom OJ. Reed KR, et al. Among authors: sansom oj. Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18919-23. doi: 10.1073/pnas.0805778105. Epub 2008 Nov 24. Proc Natl Acad Sci U S A. 2008. PMID: 19033191 Free PMC article.

9

Crypt stem cells as the cells-of-origin of intestinal cancer.

Barker N, Ridgway RA, van Es JH, van de Wetering M, Begthel H, van den Born M, Danenberg E, Clarke AR, Sansom OJ, Clevers H. Barker N, et al. Among authors: sansom oj. Nature. 2009 Jan 29;457(7229):608-11. doi: 10.1038/nature07602. Epub 2008 Dec 17. Nature. 2009. PMID: 19092804

10

APC as a master regulator of intestinal homeostasis and transformation: from flies to vertebrates.

Cordero J, Vidal M, Sansom O. Cordero J, et al. Cell Cycle. 2009 Sep 15;8(18):2926-31. Epub 2009 Sep 8. Cell Cycle. 2009. PMID: 19657225

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