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Systematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation.
Lázaro DF, Rodrigues EF, Langohr R, Shahpasandzadeh H, Ribeiro T, Guerreiro P, Gerhardt E, Kröhnert K, Klucken J, Pereira MD, Popova B, Kruse N, Mollenhauer B, Rizzoli SO, Braus GH, Danzer KM, Outeiro TF. Lázaro DF, et al. Among authors: guerreiro p. PLoS Genet. 2014 Nov 13;10(11):e1004741. doi: 10.1371/journal.pgen.1004741. eCollection 2014 Nov. PLoS Genet. 2014. PMID: 25393002 Free PMC article.
LRRK2 Promotes Tau Accumulation, Aggregation and Release.
Guerreiro PS, Gerhardt E, Lopes da Fonseca T, Bähr M, Outeiro TF, Eckermann K. Guerreiro PS, et al. Mol Neurobiol. 2016 Jul;53(5):3124-3135. doi: 10.1007/s12035-015-9209-z. Epub 2015 May 27. Mol Neurobiol. 2016. PMID: 26014385
α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner.
Yin G, Lopes da Fonseca T, Eisbach SE, Anduaga AM, Breda C, Orcellet ML, Szegő ÉM, Guerreiro P, Lázaro DF, Braus GH, Fernandez CO, Griesinger C, Becker S, Goody RS, Itzen A, Giorgini F, Outeiro TF, Zweckstetter M. Yin G, et al. Among authors: guerreiro p. Neurobiol Dis. 2014 Oct;70:149-61. doi: 10.1016/j.nbd.2014.06.018. Epub 2014 Jun 28. Neurobiol Dis. 2014. PMID: 24983211
The small GTPase Rab11 co-localizes with α-synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity.
Chutna O, Gonçalves S, Villar-Piqué A, Guerreiro P, Marijanovic Z, Mendes T, Ramalho J, Emmanouilidou E, Ventura S, Klucken J, Barral DC, Giorgini F, Vekrellis K, Outeiro TF. Chutna O, et al. Among authors: guerreiro p. Hum Mol Genet. 2014 Dec 20;23(25):6732-45. doi: 10.1093/hmg/ddu391. Epub 2014 Aug 4. Hum Mol Genet. 2014. PMID: 25092884
The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.
de Oliveira RM, Vicente Miranda H, Francelle L, Pinho R, Szegö ÉM, Martinho R, Munari F, Lázaro DF, Moniot S, Guerreiro P, Fonseca-Ornelas L, Marijanovic Z, Antas P, Gerhardt E, Enguita FJ, Fauvet B, Penque D, Pais TF, Tong Q, Becker S, Kügler S, Lashuel HA, Steegborn C, Zweckstetter M, Outeiro TF. de Oliveira RM, et al. Among authors: guerreiro p. PLoS Biol. 2017 Mar 3;15(3):e2000374. doi: 10.1371/journal.pbio.2000374. eCollection 2017 Mar. PLoS Biol. 2017. PMID: 28257421 Free PMC article.
Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation.
Diógenes MJ, Dias RB, Rombo DM, Vicente Miranda H, Maiolino F, Guerreiro P, Näsström T, Franquelim HG, Oliveira LM, Castanho MA, Lannfelt L, Bergström J, Ingelsson M, Quintas A, Sebastião AM, Lopes LV, Outeiro TF. Diógenes MJ, et al. Among authors: guerreiro p. J Neurosci. 2012 Aug 22;32(34):11750-62. doi: 10.1523/JNEUROSCI.0234-12.2012. J Neurosci. 2012. PMID: 22915117 Free PMC article.
MPV17 Mutations Are Associated With a Quiescent Energetic Metabolic Profile.
Jacinto S, Guerreiro P, de Oliveira RM, Cunha-Oliveira T, Santos MJ, Grazina M, Rego AC, Outeiro TF. Jacinto S, et al. Among authors: guerreiro p. Front Cell Neurosci. 2021 Mar 17;15:641264. doi: 10.3389/fncel.2021.641264. eCollection 2021. Front Cell Neurosci. 2021. PMID: 33815063 Free PMC article.
114 results