Humber L - Search Results

1

Computer-assisted design and synthesis of novel aldose reductase inhibitors.

Butera J, Bagli J, Doubleday W, Humber L, Treasurywala A, Loughney D, Sestanj K, Millen J, Sredy J. Butera J, et al. Among authors: humber l. J Med Chem. 1989 Apr;32(4):757-65. doi: 10.1021/jm00124a006. J Med Chem. 1989. PMID: 2539477

2

N-[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]- N-methylglycine (Tolrestat), a potent, orally active aldose reductase inhibitor.

Sestanj K, Bellini F, Fung S, Abraham N, Treasurywala A, Humber L, Simard-Duquesne N, Dvornik D. Sestanj K, et al. Among authors: humber l. J Med Chem. 1984 Mar;27(3):255-6. doi: 10.1021/jm00369a003. J Med Chem. 1984. PMID: 6422042 No abstract available.

3

Ligand-receptor interactions via hydrogen-bond formation. Synthesis and pharmacological evaluation of pyrrolo and pyrido analogues of the cardiotonic agent 7-hydroxycyclindole.

Dionne G, Humber LG, Asselin A, McQuillan J, Treasurywala AM. Dionne G, et al. Among authors: humber lg. J Med Chem. 1986 Aug;29(8):1452-7. doi: 10.1021/jm00158a022. J Med Chem. 1986. PMID: 3735312

4

Synthesis and analgesic activity of pemedolac (cis-1-ethyl-1,3,4,9-tetrahydro-4-(phenylmethyl)pyrano[3,4-b]ind ole-1- acetic acid).

Katz AH, Demerson CA, Shaw CC, Asselin AA, Humber LG, Conway KM, Gavin G, Guinosso C, Jensen NP, Mobilio D, et al. Katz AH, et al. Among authors: humber lg. J Med Chem. 1988 Jun;31(6):1244-50. doi: 10.1021/jm00401a029. J Med Chem. 1988. PMID: 3373493

5

Synthesis and biological evaluation of 4,6-diethyl-1,3,4,5-tetrahydropyrano[4,3-b]indole-4-acetic acid, an isomer of etodolac.

Hughes P, DeVirgilio J, Humber LG, Chau T, Weichman B, Neuman G. Hughes P, et al. Among authors: humber lg. J Med Chem. 1989 Sep;32(9):2134-7. doi: 10.1021/jm00129a018. J Med Chem. 1989. PMID: 2527995

6

Structure-activity relationships among analogues of pemedolac, cis-1-ethyl-1,3,4,9-tetrahydro-4-(phenylmethyl)pyrano[3,4-b]indo le-1-a cetic acid, a potent analgesic agent.

Mobilio D, Humber LG, Katz AH, Demerson CA, Hughes P, Brigance R, Conway K, Shah U, Williams G, Labbadia F, et al. Mobilio D, et al. Among authors: humber lg. J Med Chem. 1988 Nov;31(11):2211-7. doi: 10.1021/jm00119a024. J Med Chem. 1988. PMID: 3263504

7

Etodolac, a novel antiinflammatory agent. The syntheses and biological evaluation of its metabolites.

Humber LG, Ferdinandi E, Demerson CA, Ahmed S, Shah U, Mobilio D, Sabatucci J, De Lange B, Labbadia F, Hughes P. Humber LG, et al. J Med Chem. 1988 Sep;31(9):1712-9. doi: 10.1021/jm00117a009. J Med Chem. 1988. PMID: 2970548

8

The medicinal chemistry of aldose reductase inhibitors.

Humber LG. Humber LG. Prog Med Chem. 1987;24:299-343. doi: 10.1016/s0079-6468(08)70425-9. Prog Med Chem. 1987. PMID: 3144023 Review. No abstract available.

9

Synthesis and analgesic evaluation of 4-(2-heptyloxy)-7-[(Z)-(3-hydroxycyclohexyl)]indole: a caveat on indole-phenol bioisosterism.

Soll RM, Humber LG, Deininger D, Asselin AA, Chau TT, Weichman BM. Soll RM, et al. Among authors: humber lg. J Med Chem. 1986 Aug;29(8):1457-60. doi: 10.1021/jm00158a023. J Med Chem. 1986. PMID: 3735313

10

Humber LG, Sideridis N, Asselin AA, Bruderlein FT, Voith K. Humber LG, et al. J Med Chem. 1978 Dec;21(12):1225-31. doi: 10.1021/jm00210a011. J Med Chem. 1978. PMID: 31480

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