Loughney D - Search Results

1

Computer-assisted design and synthesis of novel aldose reductase inhibitors.

Butera J, Bagli J, Doubleday W, Humber L, Treasurywala A, Loughney D, Sestanj K, Millen J, Sredy J. Butera J, et al. Among authors: loughney d. J Med Chem. 1989 Apr;32(4):757-65. doi: 10.1021/jm00124a006. J Med Chem. 1989. PMID: 2539477

2

HMG-CoA reductase inhibitors: design, synthesis, and biological activity of tetrahydroindazole-substituted 3,5-dihydroxy-6-heptenoic acid sodium salts.

Connolly PJ, Westin CD, Loughney DA, Minor LK. Connolly PJ, et al. Among authors: loughney da. J Med Chem. 1993 Nov 12;36(23):3674-85. doi: 10.1021/jm00075a024. J Med Chem. 1993. PMID: 8246237

3

Tryptamine and homotryptamine-based sulfonamides as potent and selective inhibitors of 15-lipoxygenase.

Weinstein DS, Liu W, Gu Z, Langevine C, Ngu K, Fadnis L, Combs DW, Sitkoff D, Ahmad S, Zhuang S, Chen X, Wang FL, Loughney DA, Atwal KS, Zahler R, Macor JE, Madsen CS, Murugesan N. Weinstein DS, et al. Among authors: loughney da. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1435-40. doi: 10.1016/j.bmcl.2004.12.081. Bioorg Med Chem Lett. 2005. PMID: 15713402

4

Trends in kinase selectivity: insights for target class-focused library screening.

Posy SL, Hermsmeier MA, Vaccaro W, Ott KH, Todderud G, Lippy JS, Trainor GL, Loughney DA, Johnson SR. Posy SL, et al. Among authors: loughney da. J Med Chem. 2011 Jan 13;54(1):54-66. doi: 10.1021/jm101195a. Epub 2010 Dec 3. J Med Chem. 2011. PMID: 21128601

5

Protein structure determination using a combination of comparative modeling and NMR spectroscopy. Application to the response regulator protein, Spo0F.

Podlogar BL, Leo GC, McDonnell PA, Loughney DA, Caldwell GW, Barrett JF. Podlogar BL, et al. Among authors: loughney da. J Med Chem. 1997 Oct 10;40(21):3453-5. doi: 10.1021/jm970156i. J Med Chem. 1997. PMID: 9341920

6

Novel thieno[2,3-b]- and [3,4-b]pyrans as potassium channel openers. Thiophene systems--XVII.

Press JB, McNally JJ, Sanfilippo PJ, Addo MF, Loughney D, Giardino E, Katz LB, Falotico R, Haertlein BJ. Press JB, et al. Among authors: loughney d. Bioorg Med Chem. 1993 Dec;1(6):423-35. doi: 10.1016/s0968-0896(00)82153-7. Bioorg Med Chem. 1993. PMID: 8087564

7

Phosphatase inhibitors--III. Benzylaminophosphonic acids as potent inhibitors of human prostatic acid phosphatase.

Beers SA, Schwender CF, Loughney DA, Malloy E, Demarest K, Jordan J. Beers SA, et al. Among authors: loughney da. Bioorg Med Chem. 1996 Oct;4(10):1693-701. doi: 10.1016/0968-0896(96)00186-1. Bioorg Med Chem. 1996. PMID: 8931939

8

A simple strategy for mitigating the effect of data variability on the identification of active chemotypes from high-throughput screening data.

Johnson SR, Padmanabha R, Vaccaro W, Hermsmeier M, Cacace A, Lawrence M, Dickey J, Esposito K, Pike K, Wong V, Poss M, Loughney D, Tebben A. Johnson SR, et al. Among authors: loughney d. J Biomol Screen. 2007 Mar;12(2):276-84. doi: 10.1177/1087057106297826. Epub 2007 Feb 1. J Biomol Screen. 2007. PMID: 17272827

9

To measure is to know: an approach to CADD performance metrics.

Loughney D, Claus BL, Johnson SR. Loughney D, et al. Drug Discov Today. 2011 Jul;16(13-14):548-54. doi: 10.1016/j.drudis.2011.05.003. Epub 2011 May 13. Drug Discov Today. 2011. PMID: 21605697

10

Approaches for machine learning intermolecular interaction energies and application to energy components from symmetry adapted perturbation theory.

Metcalf DP, Koutsoukas A, Spronk SA, Claus BL, Loughney DA, Johnson SR, Cheney DL, Sherrill CD. Metcalf DP, et al. Among authors: loughney da. J Chem Phys. 2020 Feb 21;152(7):074103. doi: 10.1063/1.5142636. J Chem Phys. 2020. PMID: 32087645

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