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Autocrine androgen action is essential for Leydig cell maturation and function, and protects against late-onset Leydig cell apoptosis in both mice and men.
O'Hara L, McInnes K, Simitsidellis I, Morgan S, Atanassova N, Slowikowska-Hilczer J, Kula K, Szarras-Czapnik M, Milne L, Mitchell RT, Smith LB. O'Hara L, et al. Among authors: milne l. FASEB J. 2015 Mar;29(3):894-910. doi: 10.1096/fj.14-255729. Epub 2014 Nov 17. FASEB J. 2015. PMID: 25404712 Free PMC article.
A young testicular microenvironment protects Leydig cells against age-related dysfunction in a mouse model of premature aging.
Curley M, Milne L, Smith S, Jørgensen A, Frederiksen H, Hadoke P, Potter P, Smith LB. Curley M, et al. Among authors: milne l. FASEB J. 2019 Jan;33(1):978-995. doi: 10.1096/fj.201800612R. Epub 2018 Aug 6. FASEB J. 2019. PMID: 30080443 Free PMC article.
We conclude that age-related LC dysfunction is largely driven by aging of the supporting testicular microenvironment.-Curley, M., Milne, L., Smith, S., Jorgensen, A., Frederiksen, H., Hadoke, P., Potter, P., Smith, L. ...
We conclude that age-related LC dysfunction is largely driven by aging of the supporting testicular microenvironment.-Curley, M., Milne …
Sertoli cells control peritubular myoid cell fate and support adult Leydig cell development in the prepubertal testis.
Rebourcet D, O'Shaughnessy PJ, Pitetti JL, Monteiro A, O'Hara L, Milne L, Tsai YT, Cruickshanks L, Riethmacher D, Guillou F, Mitchell RT, van't Hof R, Freeman TC, Nef S, Smith LB. Rebourcet D, et al. Among authors: milne l. Development. 2014 May;141(10):2139-49. doi: 10.1242/dev.107029. Development. 2014. PMID: 24803659 Free PMC article.
Sertoli Cells Modulate Testicular Vascular Network Development, Structure, and Function to Influence Circulating Testosterone Concentrations in Adult Male Mice.
Rebourcet D, Wu J, Cruickshanks L, Smith SE, Milne L, Fernando A, Wallace RJ, Gray CD, Hadoke PW, Mitchell RT, O'Shaughnessy PJ, Smith LB. Rebourcet D, et al. Among authors: milne l. Endocrinology. 2016 Jun;157(6):2479-88. doi: 10.1210/en.2016-1156. Epub 2016 May 4. Endocrinology. 2016. PMID: 27145015 Free PMC article.
250 results