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Modulation of the maladaptive stress response to manage diseases of protein folding.
Roth DM, Hutt DM, Tong J, Bouchecareilh M, Wang N, Seeley T, Dekkers JF, Beekman JM, Garza D, Drew L, Masliah E, Morimoto RI, Balch WE. Roth DM, et al. Among authors: balch we. PLoS Biol. 2014 Nov 18;12(11):e1001998. doi: 10.1371/journal.pbio.1001998. eCollection 2014 Nov. PLoS Biol. 2014. PMID: 25406061 Free PMC article.
Adapting proteostasis for disease intervention.
Balch WE, Morimoto RI, Dillin A, Kelly JW. Balch WE, et al. Science. 2008 Feb 15;319(5865):916-9. doi: 10.1126/science.1141448. Science. 2008. PMID: 18276881 Review.
Chemical and biological folding contribute to temperature-sensitive DeltaF508 CFTR trafficking.
Wang X, Koulov AV, Kellner WA, Riordan JR, Balch WE. Wang X, et al. Among authors: balch we. Traffic. 2008 Nov;9(11):1878-93. doi: 10.1111/j.1600-0854.2008.00806.x. Epub 2008 Jul 30. Traffic. 2008. PMID: 18764821 Free PMC article.
Proteostasis (Balch WE, Morimoto RI, Dillin A, Kelly JW. Adapting proteostasis for disease intervention. ...We find that DeltaF508 export requires a local biological folding environment that is sensitive to heat/stress-inducible factors found in some cell typ …
Proteostasis (Balch WE, Morimoto RI, Dillin A, Kelly JW. Adapting proteostasis for disease intervention. ...We find tha …
The proteostasis boundary in misfolding diseases of membrane traffic.
Hutt DM, Powers ET, Balch WE. Hutt DM, et al. Among authors: balch we. FEBS Lett. 2009 Aug 20;583(16):2639-46. doi: 10.1016/j.febslet.2009.07.014. FEBS Lett. 2009. PMID: 19708088 Free PMC article. Review.
Protein function is regulated by the proteostasis network (PN) [Balch, W.E., Morimoto, R.I., Dillin, A. and Kelly, J.W. (2008) Adapting proteostasis for disease intervention. ...We emphasize the enabling principle of a 'proteostasis boundary (PB)' [Powers, E.T., Mor …
Protein function is regulated by the proteostasis network (PN) [Balch, W.E., Morimoto, R.I., Dillin, A. and Kelly, J.W. (2008) Adapti …
Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis.
Hutt DM, Herman D, Rodrigues AP, Noel S, Pilewski JM, Matteson J, Hoch B, Kellner W, Kelly JW, Schmidt A, Thomas PJ, Matsumura Y, Skach WR, Gentzsch M, Riordan JR, Sorscher EJ, Okiyoneda T, Yates JR 3rd, Lukacs GL, Frizzell RA, Manning G, Gottesfeld JM, Balch WE. Hutt DM, et al. Among authors: balch we. Nat Chem Biol. 2010 Jan;6(1):25-33. doi: 10.1038/nchembio.275. Epub 2009 Dec 6. Nat Chem Biol. 2010. PMID: 19966789 Free PMC article.
Cell Biology. The proteome in balance.
Hutt D, Balch WE. Hutt D, et al. Among authors: balch we. Science. 2010 Aug 13;329(5993):766-7. doi: 10.1126/science.1194160. Science. 2010. PMID: 20705837 Free PMC article. No abstract available.
244 results