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Exploring the structural basis of the selective inhibition of monoamine oxidase A by dicarbonitrile aminoheterocycles: role of Asn181 and Ile335 validated by spectroscopic and computational studies.
Juárez-Jiménez J, Mendes E, Galdeano C, Martins C, Silva DB, Marco-Contelles J, do Carmo Carreiras M, Luque FJ, Ramsay RR. Juárez-Jiménez J, et al. Among authors: ramsay rr. Biochim Biophys Acta. 2014 Feb;1844(2):389-97. doi: 10.1016/j.bbapap.2013.11.003. Epub 2013 Nov 15. Biochim Biophys Acta. 2014. PMID: 24247011
Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3 R Antagonism for Neurodegenerative Diseases.
Bautista-Aguilera ÓM, Hagenow S, Palomino-Antolin A, Farré-Alins V, Ismaili L, Joffrin PL, Jimeno ML, Soukup O, Janočková J, Kalinowsky L, Proschak E, Iriepa I, Moraleda I, Schwed JS, Romero Martínez A, López-Muñoz F, Chioua M, Egea J, Ramsay RR, Marco-Contelles J, Stark H. Bautista-Aguilera ÓM, et al. Among authors: ramsay rr. Angew Chem Int Ed Engl. 2017 Oct 2;56(41):12765-12769. doi: 10.1002/anie.201706072. Epub 2017 Sep 1. Angew Chem Int Ed Engl. 2017. PMID: 28861918
N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor.
Bautista-Aguilera OM, Samadi A, Chioua M, Nikolic K, Filipic S, Agbaba D, Soriano E, de Andrés L, Rodríguez-Franco MI, Alcaro S, Ramsay RR, Ortuso F, Yañez M, Marco-Contelles J. Bautista-Aguilera OM, et al. Among authors: ramsay rr. J Med Chem. 2014 Dec 26;57(24):10455-63. doi: 10.1021/jm501501a. Epub 2014 Dec 8. J Med Chem. 2014. PMID: 25418133
Synthesis, biological evaluation, and molecular modeling of nitrile-containing compounds: Exploring multiple activities as anti-Alzheimer agents.
Silva D, Mendes E, Summers EJ, Neca A, Jacinto AC, Reis T, Agostinho P, Bolea I, Jimeno ML, Mateus ML, Oliveira-Campos AMF, Unzeta M, Marco-Contelles J, Majekova M, Ramsay RR, Carreiras MC. Silva D, et al. Among authors: ramsay rr. Drug Dev Res. 2020 Apr;81(2):215-231. doi: 10.1002/ddr.21594. Epub 2019 Aug 30. Drug Dev Res. 2020. PMID: 31471933
Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease.
Unzeta M, Esteban G, Bolea I, Fogel WA, Ramsay RR, Youdim MB, Tipton KF, Marco-Contelles J. Unzeta M, et al. Among authors: ramsay rr. Front Neurosci. 2016 May 25;10:205. doi: 10.3389/fnins.2016.00205. eCollection 2016. Front Neurosci. 2016. PMID: 27252617 Free PMC article. Review.
147 results