Lakins J - Search Results

1

A 3D tension bioreactor platform to study the interplay between ECM stiffness and tumor phenotype.

Cassereau L, Miroshnikova YA, Ou G, Lakins J, Weaver VM. Cassereau L, et al. Among authors: lakins j. J Biotechnol. 2015 Jan 10;193:66-9. doi: 10.1016/j.jbiotec.2014.11.008. Epub 2014 Nov 27. J Biotechnol. 2015. PMID: 25435379 Free PMC article.

2

Exploring the link between human embryonic stem cell organization and fate using tension-calibrated extracellular matrix functionalized polyacrylamide gels.

Lakins JN, Chin AR, Weaver VM. Lakins JN, et al. Methods Mol Biol. 2012;916:317-50. doi: 10.1007/978-1-61779-980-8_24. Methods Mol Biol. 2012. PMID: 22914951

3

Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression.

Mouw JK, Yui Y, Damiano L, Bainer RO, Lakins JN, Acerbi I, Ou G, Wijekoon AC, Levental KR, Gilbert PM, Hwang ES, Chen YY, Weaver VM. Mouw JK, et al. Nat Med. 2014 Apr;20(4):360-7. doi: 10.1038/nm.3497. Epub 2014 Mar 16. Nat Med. 2014. PMID: 24633304 Free PMC article.

4

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.

Laklai H, Miroshnikova YA, Pickup MW, Collisson EA, Kim GE, Barrett AS, Hill RC, Lakins JN, Schlaepfer DD, Mouw JK, LeBleu VS, Roy N, Novitskiy SV, Johansen JS, Poli V, Kalluri R, Iacobuzio-Donahue CA, Wood LD, Hebrok M, Hansen K, Moses HL, Weaver VM. Laklai H, et al. Nat Med. 2016 May;22(5):497-505. doi: 10.1038/nm.4082. Epub 2016 Apr 18. Nat Med. 2016. PMID: 27089513 Free PMC article.

5

Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation.

Przybyla L, Lakins JN, Weaver VM. Przybyla L, et al. Cell Stem Cell. 2016 Oct 6;19(4):462-475. doi: 10.1016/j.stem.2016.06.018. Epub 2016 Jul 21. Cell Stem Cell. 2016. PMID: 27452175 Free PMC article.

6

Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics.

Muncie JM, Falcón-Banchs R, Lakins JN, Sohn LL, Weaver VM. Muncie JM, et al. J Vis Exp. 2019 Sep 28;(151):10.3791/60334. doi: 10.3791/60334. J Vis Exp. 2019. PMID: 31609314 Free PMC article.

7

Mechanical Tension Promotes Formation of Gastrulation-like Nodes and Patterns Mesoderm Specification in Human Embryonic Stem Cells.

Muncie JM, Ayad NME, Lakins JN, Xue X, Fu J, Weaver VM. Muncie JM, et al. Among authors: lakins jn. Dev Cell. 2020 Dec 21;55(6):679-694.e11. doi: 10.1016/j.devcel.2020.10.015. Epub 2020 Nov 17. Dev Cell. 2020. PMID: 33207224 Free PMC article.

8

Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression.

Maller O, Drain AP, Barrett AS, Borgquist S, Ruffell B, Zakharevich I, Pham TT, Gruosso T, Kuasne H, Lakins JN, Acerbi I, Barnes JM, Nemkov T, Chauhan A, Gruenberg J, Nasir A, Bjarnadottir O, Werb Z, Kabos P, Chen YY, Hwang ES, Park M, Coussens LM, Nelson AC, Hansen KC, Weaver VM. Maller O, et al. Among authors: lakins jn. Nat Mater. 2021 Apr;20(4):548-559. doi: 10.1038/s41563-020-00849-5. Epub 2020 Nov 30. Nat Mater. 2021. PMID: 33257795 Free PMC article.

9

Matrix compliance permits NF-κB activation to drive therapy resistance in breast cancer.

Drain AP, Zahir N, Northey JJ, Zhang H, Huang PJ, Maller O, Lakins JN, Yu X, Leight JL, Alston-Mills BP, Hwang ES, Chen YY, Park CC, Weaver VM. Drain AP, et al. Among authors: lakins jn. J Exp Med. 2021 May 3;218(5):e20191360. doi: 10.1084/jem.20191360. J Exp Med. 2021. PMID: 33822843 Free PMC article.

10

Tensional homeostasis and the malignant phenotype.

Paszek MJ, Zahir N, Johnson KR, Lakins JN, Rozenberg GI, Gefen A, Reinhart-King CA, Margulies SS, Dembo M, Boettiger D, Hammer DA, Weaver VM. Paszek MJ, et al. Among authors: lakins jn. Cancer Cell. 2005 Sep;8(3):241-54. doi: 10.1016/j.ccr.2005.08.010. Cancer Cell. 2005. PMID: 16169468 Free article.

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