Hughes MP - Search Results

1

Perinatal systemic gene delivery using adeno-associated viral vectors.

Karda R, Buckley SM, Mattar CN, Ng J, Massaro G, Hughes MP, Kurian MA, Baruteau J, Gissen P, Chan JK, Bacchelli C, Waddington SN, Rahim AA. Karda R, et al. Among authors: hughes mp. Front Mol Neurosci. 2014 Nov 14;7:89. doi: 10.3389/fnmol.2014.00089. eCollection 2014. Front Mol Neurosci. 2014. PMID: 25452713 Free PMC article. Review.

2

Immediate Remote Ischemic Postconditioning Reduces Brain Nitrotyrosine Formation in a Piglet Asphyxia Model.

Rocha-Ferreira E, Rudge B, Hughes MP, Rahim AA, Hristova M, Robertson NJ. Rocha-Ferreira E, et al. Among authors: hughes mp. Oxid Med Cell Longev. 2016;2016:5763743. doi: 10.1155/2016/5763743. Epub 2016 Jun 9. Oxid Med Cell Longev. 2016. PMID: 27379176 Free PMC article.

3

AAV9 intracerebroventricular gene therapy improves lifespan, locomotor function and pathology in a mouse model of Niemann-Pick type C1 disease.

Hughes MP, Smith DA, Morris L, Fletcher C, Colaco A, Huebecker M, Tordo J, Palomar N, Massaro G, Henckaerts E, Waddington SN, Platt FM, Rahim AA. Hughes MP, et al. Hum Mol Genet. 2018 Sep 1;27(17):3079-3098. doi: 10.1093/hmg/ddy212. Hum Mol Genet. 2018. PMID: 29878115 Free PMC article.

4

Argininosuccinic aciduria fosters neuronal nitrosative stress reversed by Asl gene transfer.

Baruteau J, Perocheau DP, Hanley J, Lorvellec M, Rocha-Ferreira E, Karda R, Ng J, Suff N, Diaz JA, Rahim AA, Hughes MP, Banushi B, Prunty H, Hristova M, Ridout DA, Virasami A, Heales S, Howe SJ, Buckley SMK, Mills PB, Gissen P, Waddington SN. Baruteau J, et al. Among authors: hughes mp. Nat Commun. 2018 Aug 29;9(1):3505. doi: 10.1038/s41467-018-05972-1. Nat Commun. 2018. PMID: 30158522 Free PMC article.

5

Epilepsy Gene Therapy Using an Engineered Potassium Channel.

Snowball A, Chabrol E, Wykes RC, Shekh-Ahmad T, Cornford JH, Lieb A, Hughes MP, Massaro G, Rahim AA, Hashemi KS, Kullmann DM, Walker MC, Schorge S. Snowball A, et al. Among authors: hughes mp. J Neurosci. 2019 Apr 17;39(16):3159-3169. doi: 10.1523/JNEUROSCI.1143-18.2019. Epub 2019 Feb 12. J Neurosci. 2019. PMID: 30755487 Free PMC article.

6

Neonatal brain-directed gene therapy rescues a mouse model of neurodegenerative CLN6 Batten disease.

Kleine Holthaus SM, Herranz-Martin S, Massaro G, Aristorena M, Hoke J, Hughes MP, Maswood R, Semenyuk O, Basche M, Shah AZ, Klaska IP, Smith AJ, Mole SE, Rahim AA, Ali RR. Kleine Holthaus SM, et al. Among authors: hughes mp. Hum Mol Genet. 2019 Dec 1;28(23):3867-3879. doi: 10.1093/hmg/ddz210. Hum Mol Genet. 2019. PMID: 31807779

7

Systemic AAV9 gene therapy using the synapsin I promoter rescues a mouse model of neuronopathic Gaucher disease but with limited cross-correction potential to astrocytes.

Massaro G, Hughes MP, Whaler SM, Wallom KL, Priestman DA, Platt FM, Waddington SN, Rahim AA. Massaro G, et al. Among authors: hughes mp. Hum Mol Genet. 2020 Jul 29;29(12):1933-1949. doi: 10.1093/hmg/ddz317. Hum Mol Genet. 2020. PMID: 31919491 Free PMC article.

8

Generation of light-producing somatic-transgenic mice using adeno-associated virus vectors.

Karda R, Rahim AA, Wong AMS, Suff N, Diaz JA, Perocheau DP, Tijani M, Ng J, Baruteau J, Martin NP, Hughes M, Delhove JMKM, Counsell JR, Cooper JD, Henckaerts E, Mckay TR, Buckley SMK, Waddington SN. Karda R, et al. Sci Rep. 2020 Feb 7;10(1):2121. doi: 10.1038/s41598-020-59075-3. Sci Rep. 2020. PMID: 32034258 Free PMC article.

9

A GLP1 receptor agonist diabetes drug ameliorates neurodegeneration in a mouse model of infantile neurometabolic disease.

Poupon-Bejuit L, Hughes MP, Liu W, Geard A, Faour-Slika N, Whaler S, Massaro G, Rahim AA. Poupon-Bejuit L, et al. Among authors: hughes mp. Sci Rep. 2022 Aug 15;12(1):13825. doi: 10.1038/s41598-022-17338-1. Sci Rep. 2022. PMID: 35970890 Free PMC article.

10

A Novel Small NPC1 Promoter Enhances AAV-Mediated Gene Therapy in Mouse Models of Niemann-Pick Type C1 Disease.

Hughes MP, Nelvagal HR, Coombe-Tennant O, Smith D, Smith C, Massaro G, Poupon-Bejuit L, Platt FM, Rahim AA. Hughes MP, et al. Cells. 2023 Jun 13;12(12):1619. doi: 10.3390/cells12121619. Cells. 2023. PMID: 37371089 Free PMC article.

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